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Deoxysphingolipids activate cGAS-STING and enhance antitumor immunity

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118089
  
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sciencedirect.com/science/article/pii/S221112472601168X
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SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.021
  
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sciencedirect.com/science/article/pii/S0092867426011232
Aug 2026
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MCT4-mediated lactate efflux promotes STING-dependent dendritic cell antitumor immunity

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1. scibot 03 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117778
  
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sciencedirect.com/science/article/pii/S2211124726008569
Jul 2026
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SCLC humanized mice identify T cell infiltration phenotypes in response to combination immune-radiation therapies

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1. scibot 27 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116864
  
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sciencedirect.com/science/article/pii/S258900422602242X
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

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1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
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Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING

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1. scibot 20 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.023
  
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sciencedirect.com/science/article/pii/S1074761326002748
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Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity

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1. scibot 14 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.010
  
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sciencedirect.com/science/article/pii/S107476132600261X
Jun 2026
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Hepatitis B virus promotes hepatocellular carcinogenesis by activating IL-6-dependent tumor-macrophage crosstalk and M2-like macrophage polarization

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.jbc.2026.113283
  
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sciencedirect.com/science/article/pii/S0021925826021551
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Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling

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1. scibot 25 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117580
  
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sciencedirect.com/science/article/pii/S2211124726006583
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VEGFR2 inhibition potentiates STING-mediated antitumor immunity

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1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117576
  
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sciencedirect.com/science/article/pii/S2211124726006546
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Characterization of a transmembrane-activating STING agonist using genetically humanized mice

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1. scibot 03 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117475
  
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sciencedirect.com/science/article/pii/S221112472600553X
May 2026
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cGAS/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant Staphylococcus aureus clinical isolates

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1. scibot 22 May 2026
  
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  DOI: 10.1016/j.isci.2026.115854
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13186032/
Apr 2026
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Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

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1. scibot 24 Apr 2026
  
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  DOI: 10.1371/journal.pone.0028316
  
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54.241.53.176/67c74b90c3375f7e65bca5ea8c2ee116db2889dc/1-s2.0-S2589004226012290-main-html.html
Mar 2026
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Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102714
  
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sciencedirect.com/science/article/pii/S266637912600131X
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MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117059
  
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sciencedirect.com/science/article/pii/S2211124726001373
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The common HAQ STING allele prevents clinical penetrance of COPA syndrome

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1. scibot 03 Mar 2026
  
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  DOI: 10.1084/jem.20242179
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11867111/
Feb 2026
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Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1

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1. scibot 24 Feb 2026
  
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  DOI: 10.1038/s41467-026-68662-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12923701/
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Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases

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1. scibot 13 Feb 2026
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.ccell.2026.01.010
  
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sciencedirect.com/science/article/pii/S1535610826000498
Dec 2025
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Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING

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1. scibot 18 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116745
  
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sciencedirect.com:5037/science/article/pii/S2211124725015177
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Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.molcel.2025.11.014
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12698191/
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Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.jbc.2025.111038
  
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sciencedirect.com:5037/science/article/pii/S002192582502890X
Sep 2025
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Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C

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1. scibot 27 Sep 2025
  
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  DOI: 10.1371/journal.pbio.3003393
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12463328/
Aug 2025
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Evolutionarily conserved role of telomerase reverse transcriptase in programming the microenvironment via regulation of the cGAS–STING pathway

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1. scibot 13 Aug 2025
  
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  DOI: 10.1038/s41556-025-01706-w
  
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nature.com/articles/s41556-025-01706-w
Jul 2025
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101106
  
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sciencedirect.com/science/article/pii/S2667237525001420
Jun 2025
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Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice

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1. scibot 15 Jun 2025
  
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  DOI: 10.1101/2025.05.09.653147
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12132566/
May 2025
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115735
  
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Reducing Dietary Protein Enhances the Antitumor Effects of Chemotherapy through Immune-Mediated Mechanisms

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1. scibot 20 May 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617599/
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SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115562
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12074670/
Mar 2025
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PDF-html.html

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1. scibot 24 Mar 2025
  
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  DOI: 10.1158/1535-7163.mct-24-0545
  
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52.53.155.43/089c935c8b8375c73eca3bfe64a1d2170a0cdb88/PDF-html.html
Feb 2025
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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

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1. scibot 13 Feb 2025
  
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  DOI: 10.1126/scitranslmed.adj9366
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
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Toxicity of extracellular cGAMP and its analogs to T cells is due to SLC7A1-mediated import

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.21.614248
  
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52.53.155.43/5ae47209b7006eb85d3adbe5cd2f83306ecd19fd/2024.09.21.614248.full-html.html
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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.004
  
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sciencedirect.com/science/article/pii/S2451945625000042
Jan 2025
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Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.immuni.2024.12.002
  
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sciencedirect.com/science/article/pii/S1074761324005661
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BPS Publications

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1. scibot 05 Jan 2025
  
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  RRID:AB_2737062
  
  DOI: 10.1111/bph.17425
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.17425
Dec 2024
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The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115094
  
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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  RRID:AB_2737062
  
  DOI: 10.1016/j.celrep.2024.115104
  
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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

1
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  DOI: 10.1016/j.molcel.2024.11.026
  
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The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

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  DOI: 10.1016/j.immuni.2024.11.017
  
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Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer

1
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  DOI: 10.1016/j.xcrm.2024.101852
  
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

1
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  DOI: 10.1016/j.cels.2024.11.004
  
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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  DOI: 10.3389/fonc.2024.1441935
  
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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

1
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  DOI: 10.1016/j.isci.2024.110693
  
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Aug 2024
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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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  DOI: 10.1016/j.isci.2024.110285
  
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PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection

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  DOI: 10.1016/j.molcel.2024.06.001
  
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May 2024
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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  DOI: 10.1016/j.redox.2024.103202
  
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Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

1
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  DOI: 10.1016/j.xcrm.2024.101528
  
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

1
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  DOI: 10.1101/2024.04.07.588166
  
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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

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  DOI: 10.1016/j.ccell.2024.04.004
  
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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Mar 2024
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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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  DOI: 10.1016/j.celrep.2024.113886
  
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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

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  DOI: 10.1016/j.celrep.2024.113870
  
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Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

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  DOI: 10.1016/j.immuni.2023.11.001
  
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Regulation of STING activity in DNA sensing by ISG15 modification

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  DOI: 10.1016/j.celrep.2023.113277
  
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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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  DOI: 10.1016/j.celrep.2023.112805
  
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May 2023
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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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  DOI: 10.1016/j.ccell.2023.04.016
  
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Apr 2023
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Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses

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  DOI: 10.1016/j.xcrm.2023.101024
  
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Mar 2023
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The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus

1
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  RRID:AB_2737062
  
  DOI: 10.1016/j.celrep.2023.112306
  
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Dec 2022
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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

2
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  RRID:AB_2737062
  
  DOI: 10.15252/embj.2022111961
  
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  DOI: 10.15252/embj.2022111961
  
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embopress.org/doi/10.15252/embj.2022111961
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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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  DOI: 10.1016/j.isci.2022.105352
  
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Sep 2022
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Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase

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  RRID:AB_2920552
  
  DOI: 10.1016/j.celrep.2022.111310
  
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ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

1
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  DOI: 10.1016/j.immuni.2022.08.006
  
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Jun 2022
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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

1
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  DOI: 10.1083/jcb.202106046
  
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May 2022
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DDX41 is required for cGAS-STING activation against DNA virus infection

1
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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  DOI: 10.1016/j.celrep.2022.110814
  
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Protocol to induce and assess cGAS-STING pathway activation in vitro

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  DOI: 10.1016/j.xpro.2022.101384
  
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Nov 2021
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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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  DOI: 10.1016/j.immuni.2021.10.004
  
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May 2021
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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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  DOI: 10.1016/j.stem.2020.06.022
  
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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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  DOI: 10.1016/j.molcel.2021.02.038
  
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sciencedirect.com/science/article/pii/S1097276521001684
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SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

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1. scibot 08 May 2021
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.molcel.2020.12.024
  
  Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)
  
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sciencedirect.com/science/article/pii/S109727652030945X
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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

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1. scibot 08 May 2021
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.molcel.2020.10.021
  
  Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)
  
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sciencedirect.com/science/article/pii/S1097276520307280
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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1. scibot 22 Apr 2021
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.ccell.2021.01.003
  
  Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)
  
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  RRIDCUR:Validated RRID:AB_2737062
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sciencedirect.com/science/article/pii/S1535610821000416
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

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1. scibot 17 Apr 2021
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.ccell.2020.05.020
  
  Resource: (Cell Signaling Technology Cat# 19781, RRID:AB_2737062)
  
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sciencedirect.com/science/article/pii/S1535610820302701
Sep 2020
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.celrep.2020.03.056
  
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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

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1. scibot 04 Sep 2020
  
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  RRID: AB_2737062
  
  DOI: 10.1016/j.celrep.2018.11.097
  
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cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
Jan 2020
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

1
1. scibot 12 Jan 2020
  
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  RRID:AB_2737062
  
  DOI: 10.1016/j.molcel.2019.02.038
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1097276519301492

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