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IL-15 and IL-21 synergy improves anti-tumor efficacy of iPSC-derived cytotoxic T cells in solid tumors

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.ymthe.2026.04.036
  
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Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

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1. scibot 09 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.012
  
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sciencedirect.com/science/article/pii/S1097276526002662
Apr 2026
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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/2159-8290.CD-25-0649
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
Mar 2026
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Targeting systemic and tumor metabolic balances with ketogenic diets enhance efficacy of therapy in FLT3-ITD acute myeloid leukemia

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  DOI: 10.1016/j.celrep.2026.117185
  
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sciencedirect.com/science/article/pii/S2211124726002639
Feb 2026
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Dual PD-1/IL-2Rα targeting restores CD8+ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC

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sciencedirect.com/science/article/pii/S2666379126000509
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Homeostatic maturation programs drive human cDC2s into a tolerogenic state

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  DOI: 10.1016/j.immuni.2026.01.028
  
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The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors

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Oct 2025
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Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cells during dual inhibition

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1. scibot 15 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113610
  
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Aug 2025
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A long-lasting prolactin stimulates galactopoiesis in mice.

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1. scibot 13 Aug 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12337787/
Jul 2025
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1-s2.0-S2589004225013732-main-html.html

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1. scibot 16 Jul 2025
  
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52.53.155.43/73ec1f388f41da4ad69bbc809bebcfccf70e9065/1-s2.0-S2589004225013732-main-html.html
May 2025
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Memory T‐Cell Phenotype in Cutaneous T‐Cell Lymphoma Is Modified by Germline Gene Gametocyte Specific Factor 1

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1. scibot 20 May 2025
  
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  DOI: 10.1111/exd.70123
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12078864/
Mar 2025
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115403
  
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sciencedirect.com/science/article/pii/S2211124725001743
Aug 2024
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Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC

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1. scibot 29 Aug 2024
  
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  DOI: 10.1186/s12964-024-01782-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11348570/
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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1. scibot 28 Aug 2024
  
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sciencedirect.com/science/article/pii/S1534580724004866
Jul 2024
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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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  DOI: 10.1016/j.immuni.2024.05.025
  
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Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110415
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11295714/
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Excess endocrine growth hormone in acromegaly promotes the aggressiveness and metastasis of triple-negative breast cancer

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110137
  
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May 2024
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The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway

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1. scibot 09 May 2024
  
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  DOI: 10.1210/endocr/bqae039
  
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bqae039-html.html

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  DOI: 10.6084/m9.figshare.24398467.v2
  
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52.53.155.43/ab567994747ba987c62f3a62774a1442bfaf3557/bqae039 (1)-html.html
Apr 2024
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Development of a chimeric cytokine receptor that captures IL-6 and enhances the antitumor response of CAR-T cells

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1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101526
  
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Oncostatin M signaling drives cancer-associated skeletal muscle wasting

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  DOI: 10.1016/j.xcrm.2024.101498
  
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sciencedirect.com/science/article/pii/S2666379124001666
Mar 2024
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VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms

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1. scibot 06 Mar 2024
  
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  DOI: 10.1016/j.celrep.2023.113661
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10851928/
Feb 2024
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Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma

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Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

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1. scibot 02 Feb 2024
  
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  DOI: 10.1158/1078-0432.CCR-22-3929
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10524644/
Dec 2023
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IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108597
  
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Nov 2023
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Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.biopha.2023.115905
  
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Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

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1. scibot 22 Nov 2023
  
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  DOI: 10.1016/j.xcrm.2023.101290
  
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Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins

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1. scibot 11 Nov 2023
  
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  DOI: 10.1097/BS9.0000000000000168
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
Oct 2023
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Adipocyte Subpopulations Mediate Growth Hormone-induced Lipolysis and Glucose Tolerance in Male Mice

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1. scibot 31 Oct 2023
  
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  DOI: 10.1210/endocr/bqad151
  
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academic.oup.com/endo/article-abstract/164/11/bqad151/7332055
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Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

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  DOI: 10.1016/j.cmet.2023.09.004
  
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sciencedirect.com/science/article/pii/S1550413123003364
Sep 2023
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Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms

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1. scibot 07 Sep 2023
  
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  DOI: 10.1158/1078-0432.CCR-22-1763
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9992133/
Jul 2023
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cd-22-0411-html.html

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  DOI: 10.1158/2159-8290.CD-22-0411
  
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52.53.155.43/453457acda6208aed297e8061921a5c2d2ddddf2/cd-22-0411-html.html
Jun 2023
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N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis

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1. scibot 08 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106924
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10239700/
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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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1. scibot 08 Jun 2023
  
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  DOI: 10.1016/j.chembiol.2023.05.007
  
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Mar 2023
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943-html.html

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  AB_2737403
  
  DOI: 10.1158/1078-0432.ccr-22-1763
  
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Dec 2022
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Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

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  DOI: 10.1016/j.isci.2022.105528
  
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Aug 2022
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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  DOI: 10.1016/j.isci.2022.104923
  
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Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway

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  DOI: 10.1016/j.celrep.2022.111158
  
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May 2022
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Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms

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  DOI: 10.1158/1535-7163.MCT-21-0317
  
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Apr 2022
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GH action in prostate cancer cells promotes proliferation limits apoptosis and regulates cancer-related gene expression

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  DOI: 10.1210/endocr/bqac031
  
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Sep 2021
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Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming

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  DOI: 10.1016/j.immuni.2021.05.005
  
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May 2021
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RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes

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  DOI: 10.1016/j.celrep.2021.109102
  
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Apr 2021
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A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

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  DOI: 10.1016/j.immuni.2021.03.020
  
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Nov 2020
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Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

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  DOI: 10.1016/j.celrep.2020.108333
  
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Sep 2020
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Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells

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  DOI: 10.1210/jendso/bvz029
  
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Jan 2020
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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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  DOI: 10.1016/j.ccell.2019.10.002
  
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Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

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  DOI: 10.1016/j.molcel.2019.10.007
  
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HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

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  DOI: 10.1016/j.ccell.2019.10.011
  
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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity

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  DOI: 10.1016/j.cmet.2019.10.015
  
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Nov 2018
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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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sciencedirect.com/science/article/pii/S0092867418313047