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Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation

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  DOI: 10.1016/j.celrep.2026.117739
  
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Jul 2026
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Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-4855
  
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aacrjournals.org/cancerres/article/85/23/4632/767291/Extracellular-Domain-Shedding-of-TROP2-Activates
Mar 2026
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Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.neuron.2026.02.003
  
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sciencedirect.com/science/article/pii/S0896627326000863
Dec 2025
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Mitochondrial VHL rewires cell metabolism in hypoxia

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.013
  
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sciencedirect.com:5037/science/article/pii/S1550413125005273
Nov 2025
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Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses

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Stabilization of RUNX1 Induced by O-GlcNAcylation Promotes PDGF-BB-Mediated Resistance to CDK4/6 Inhibitors in Breast Cancer

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1. scibot 20 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2492
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12625700/
Oct 2025
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IGF2BP2 stabilized by USP7 promotes cancer-associated fibroblast activation and attenuates gemcitabine sensitivity in PDAC

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Reversal of diet-induced obesity by central insulin sensitizer FSTL1

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1. scibot 22 Oct 2025
  
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Sep 2025
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UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma

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1. scibot 20 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12434397/
Jun 2025
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Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostate cancer

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  DOI: 10.1016/j.molcel.2025.06.004
  
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sciencedirect.com/science/article/pii/S1097276525005040
May 2025
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Activation of an antifungal pathway in Yersinia pseudotuberculosis by chitin-receptor-mediated fungal recognition

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.cub.2025.04.072
  
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Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.028
  
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sciencedirect.com/science/article/pii/S1074761325001918
Apr 2025
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Cytosolic cytochrome c represses ferroptosis

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1. scibot 15 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.014
  
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sciencedirect.com/science/article/pii/S1550413125001494
Feb 2025
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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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1. scibot 27 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.016
  
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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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1. scibot 08 Feb 2025
  
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  DOI: 10.1038/s41467-025-56564-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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1. scibot 28 Aug 2024
  
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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.014
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
Jul 2024
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK

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1. scibot 30 Jul 2024
  
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cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
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Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity

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1. scibot 24 Jul 2024
  
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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

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pmc.ncbi.nlm.nih.gov/articles/PMC11442470/
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A highly selective inhibitor of discoidin domain receptor-1 (DDR1-IN-1) protects corneal epithelial cells from YAP/ACSL4-mediated ferroptosis in dry eye

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1. scibot 16 Jul 2024
  
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  DOI: 10.1111/bph.16491
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16491
Feb 2024
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Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses

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1. scibot 28 Feb 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10879709/
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TRPM2 enhances ischemic excitotoxicity by associating with PKCγ

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1. scibot 06 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113722
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11023021/
Jan 2024
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Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer

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Nov 2023
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Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis

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1. scibot 10 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113377
  
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Oct 2023
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MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

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1. scibot 31 Oct 2023
  
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  DOI: 10.1186/s13041-023-01064-4
  
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AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis

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1. scibot 06 Oct 2023
  
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cell.com/cell-reports/abstract/S2211-1247(23)01121-X
Sep 2023
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A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants

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1. scibot 14 Sep 2023
  
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Jun 2023
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Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis

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cell.com/cell-host-microbe/fulltext/S1931-3128(23)00200-7
May 2023
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

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1. scibot 24 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112557
  
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sciencedirect.com/science/article/pii/S2211124723005685
Mar 2023
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S100A8/S100A9 promote progression of multiple myeloma via expansion of megakaryocytes

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1. scibot 16 Mar 2023
  
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  DOI: 10.1158/2767-9764.CRC-22-0368
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10010194/
Jan 2023
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SUMOylation of HNRNPA2B1 modulates RPA dynamics during unperturbed replication and genotoxic stress responses

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1. scibot 26 Jan 2023
  
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  DOI: 10.1016/j.molcel.2023.01.003
  
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients

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1. scibot 06 Jan 2023
  
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  DOI: 10.1016/j.molcel.2022.12.013
  
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sciencedirect.com/science/article/pii/S1097276522011704
Dec 2022
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DLL3 regulates Notch signaling in small cell lung cancer

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1. scibot 09 Dec 2022
  
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  DOI: 10.1016/j.isci.2022.105603
  
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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling

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Tripartite Motif 38 Attenuates Cardiac Fibrosis after Myocardial Infarction by Suppressing TAK1 Activation via TAB2/3 Degradation

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C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

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A negative feedback loop of TOR signaling balances growth and stress-response trade-offs in plants

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MiR-205-5p/GGCT attenuates growth and metastasis of papillary thyroid cancer by regulating CD44

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A multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens

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Evolution of a histone variant involved in compartmental regulation of NAD metabolism

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Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species

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CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays

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Untitled document

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

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Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets

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The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation

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Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

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A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion

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The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers

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