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Oxidative DNA damage drives centromere fragility and chromosome instability

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1. scibot 11 Oct 2026
  
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  DOI: 10.1016/j.celrep.2026.118109
  
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sciencedirect.com/science/article/pii/S2211124726011885
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PARG Governs a PARylation–Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination–Mediated Chemoresistance

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1. scibot 06 Oct 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-4984
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13575561/
Aug 2026
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The BRCT domain enhances DNA binding and catalytic efficiency of fungal PARPs

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1. scibot 28 Aug 2026
  
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  DOI: 10.1038/s41467-026-75844-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13507078/
Jun 2026
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FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity

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1. scibot 17 Jun 2026
  
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  DOI: 10.1016/j.molcel.2026.05.027
  
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sciencedirect.com/science/article/pii/S1097276526003515
May 2026
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S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.016
  
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sciencedirect.com/science/article/pii/S1097276526002704
Apr 2026
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ACYP2 induces temozolomide resistance in glioblastoma by promoting PARP1-mediated DNA damage repair

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1. scibot 23 Apr 2026
  
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  DOI: 10.1158/1541-7786.MCR-25-0423
  
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aacrjournals.org/mcr/article/24/1/7/771152/ACYP2-Induces-Temozolomide-Resistance-in
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BRCA2-dependent maturation of nascent strands during DNA replication

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  DOI: 10.1016/j.molcel.2026.03.012
  
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sciencedirect.com/science/article/pii/S1097276526001681
Jan 2026
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Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity

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1. scibot 27 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116910
  
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sciencedirect.com/science/article/pii/S2211124725016821
Oct 2025
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116433
  
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sciencedirect.com/science/article/pii/S2211124725012045
Mar 2025
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PDF-html.html

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  DOI: 10.1016/j.isci.2025.112267
  
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52.53.155.43/d344e977de6cef56b410bcee491d46d791862320/PDF-html.html
Feb 2025
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PARP7 Inhibitors and AHR Agonists Act Synergistically Across a Wide-Range of Cancer Models

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0211
  
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aacrjournals.org/mct/article/24/1/56/750662/PARP7-Inhibitors-and-AHR-Agonists-Act
Dec 2024
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Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

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1. scibot 27 Dec 2024
  
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  DOI: 10.1016/j.neo.2024.101092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
Nov 2024
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Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

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1. scibot 17 Nov 2024
  
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  DOI: 10.7554/eLife.98524
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11534337/
Sep 2024
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Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy

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1. scibot 27 Sep 2024
  
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  DOI: 10.1002/glia.24612
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24612
Aug 2024
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Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

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1. scibot 21 Aug 2024
  
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  DOI: 10.1038/s41388-024-03094-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
52.53.155.43 52.53.155.43

PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

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1. scibot 13 Aug 2024
  
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  DOI: 10.1038/s44318-024-00043-2
  
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52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
Jul 2024
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N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma

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1. scibot 27 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11270646/
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ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines

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1. scibot 12 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114433
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00762-9
May 2024
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Retron-Eco1 assembles NAD+-hydrolyzing filaments that provide immunity against bacteriophages

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.molcel.2024.05.001
  
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sciencedirect.com/science/article/pii/S1097276524003940
Apr 2024
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PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair

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1. scibot 18 Apr 2024
  
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  Cell SignalingCat# 83732
  
  DOI: 10.1038/s44318-024-00043-2
  
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52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
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BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.011
  
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The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity

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1. scibot 02 Apr 2024
  
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  DOI: 10.1016/j.cell.2024.03.002
  
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  DOI: 10.1016/j.cell.2024.03.002
  
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sciencedirect.com/science/article/pii/S0092867424002502
Feb 2024
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53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

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1. scibot 22 Feb 2024
  
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  DOI: 10.1101/2023.09.27.559698
  
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52.53.155.43/9b07aa3872d935df1f2ff4d73fc96f76996bcf22/2023.09.27.559698v1.full-html.html
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Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex

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1. scibot 21 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113789
  
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sciencedirect.com/science/article/pii/S2211124724001177
Dec 2023
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53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

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  DOI: 10.1016/j.celrep.2023.113412
  
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sciencedirect.com/science/article/pii/S2211124723014249
Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

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  DOI: 10.1016/j.celrep.2023.113113
  
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PARP1 inhibition protects mice against Japanese encephalitis virus infection

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  DOI: 10.1016/j.celrep.2023.113103
  
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sciencedirect.com/science/article/pii/S2211124723011142
Jun 2023
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Molecular basis for the reversible ADP-ribosylation of guanosine bases

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  DOI: 10.1016/j.molcel.2023.06.013
  
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sciencedirect.com/science/article/pii/S1097276523004574
Apr 2023
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Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

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  DOI: 10.1016/j.molcel.2023.03.027
  
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sciencedirect.com/science/article/pii/S109727652300240X
Feb 2023
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PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

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  DOI: 10.1016/j.celrep.2023.112060
  
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sciencedirect.com/science/article/pii/S2211124723000712
Dec 2022
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Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.chembiol.2022.11.012
  
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sciencedirect.com/science/article/pii/S2451945622004184
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A Simple Method to Study ADP-Ribosylation Reversal: From Function to Drug Discovery

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1. scibot 17 Dec 2022
  
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  DOI: 10.1007/978-1-0716-2891-1_8
  
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link.springer.com/protocol/10.1007/978-1-0716-2891-1_8
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Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

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1. scibot 11 Dec 2022
  
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  DOI: 10.1016/j.chembiol.2022.11.006
  
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sciencedirect.com/science/article/pii/S2451945622004123
Oct 2022
www.nature.com www.nature.com

C9orf72 functions in the nucleus to regulate DNA damage repair

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  DOI: 10.1038/s41418-022-01074-0
  
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nature.com/articles/s41418-022-01074-0
Jun 2022
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MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

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1. scibot 03 Jun 2022
  
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  RRID:AB_2749858
  
  DOI: 10.1016/j.celrep.2022.110879
  
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sciencedirect.com/science/article/pii/S2211124722006544
Mar 2022
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Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex

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1. scibot 30 Mar 2022
  
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  RRID:AB_2749858
  
  DOI: 10.1016/j.celrep.2022.110421
  
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sciencedirect.com/science/article/pii/S2211124722001450
Feb 2022
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Poly(ADP-ribose) drives condensation of FUS via a transient interaction

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1. scibot 23 Feb 2022
  
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  DOI: 10.1016/j.molcel.2022.01.018
  
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sciencedirect.com/science/article/pii/S1097276522000612
Aug 2021
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Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors

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1. scibot 17 Aug 2021
  
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  DOI: 10.1016/j.chom.2021.07.011
  
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Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

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1. scibot 15 Aug 2021
  
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  DOI: 10.7554/eLife.59828
  
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Jul 2021
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A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity

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1. scibot 27 Jul 2021
  
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  DOI: 10.1016/j.chembiol.2018.09.011
  
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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

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  DOI: 10.1016/j.ccell.2021.06.018
  
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Feb 2021
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Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets

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  DOI: 10.7554/eLife.60480
  
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Jan 2021
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FOS licenses early events in stem cell activation driving skeletal muscle regeneration

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  DOI: 10.1016/j.celrep.2020.108656
  
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