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CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1

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1. scibot 07 Oct 2026
  
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  DOI: 10.1186/s12943-026-02575-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12998327/
Sep 2026
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Deficiency in POLE Exonuclease Causes Synthetic Lethality in Highly Aneuploid Cancer Cells

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1. scibot 04 Sep 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3977
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13535316/
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Epi-Allele elicits compensatory expression of the non-targeted allele and prevents haploinsufficiency in dominant genetic diseases

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1. scibot 04 Sep 2026
  
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  DOI: 10.1016/j.stem.2026.08.004
  
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sciencedirect.com/science/article/pii/S193459092600305X
Aug 2026
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E3 Ubiquitin Ligase Mindbomb1 Is a Novel Negative Regulator of Tumor-Suppressive BMP Signaling

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1. scibot 21 Aug 2026
  
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  DOI: 10.1158/2767-9764.CRC-25-0760
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13489675/
Jul 2026
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USP2 stabilizes POU2F3 and represents a therapeutic vulnerability in POU2F3-positive small cell lung cancer

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1. scibot 06 Jul 2026
  
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  DOI: 10.1016/j.cpblue.2026.100071
  
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sciencedirect.com/science/article/pii/S3051383926000691
May 2026
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Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia

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1. scibot 13 May 2026
  
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  DOI: 10.1016/j.molcel.2026.04.019
  
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sciencedirect.com/science/article/pii/S109727652600273X
Apr 2026
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TCA cycle rewiring underpins histone acetylation sourcing and cell-fate transitions during exit from naive pluripotency

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1. scibot 25 Apr 2026
  
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  DOI: 10.1016/j.stem.2026.04.004
  
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A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina

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1. scibot 10 Apr 2026
  
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  DOI: 10.1016/j.neuron.2026.03.022
  
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sciencedirect.com/science/article/pii/S0896627326002138
Mar 2026
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Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

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1. scibot 18 Mar 2026
  
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  DOI: 10.1016/j.stem.2025.12.019
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12973372/
Feb 2026
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Prevention of transgene silencing during human pluripotent stem cell differentiation

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.stem.2026.01.007
  
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sciencedirect.com/science/article/pii/S1934590926000305
Jan 2026
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CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.xcrm.2025.102565
  
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sciencedirect.com/science/article/pii/S266637912500638X
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Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116850
  
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sciencedirect.com/science/article/pii/S2211124725016225
Aug 2025
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S153458072500499X
Jul 2025
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Uncovering novel lncRNAs linked to melanoma growth and migration with CRISPR-inhibition screening

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1. scibot 11 Jul 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0416
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12238846/
Jun 2025
52.53.155.43 52.53.155.43

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1
1. scibot 12 Jun 2025
  
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  DOI: 10.1158/0008-5472.can-24-3785
  
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52.53.155.43/6d05284590fa38103d7fbc1633c815ab1c347fcd/PDF-html.html
Mar 2025
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Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification

1
1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.xgen.2025.100815
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12008804/
Feb 2025
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Hypoxia-induced CTCF mediates alternative splicing via coupling chromatin looping and RNA Pol II pause to promote EMT in breast cancer

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115267
  
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sciencedirect.com/science/article/pii/S2211124725000385
Aug 2024
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.isci.2024.110499
  
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sciencedirect.com/science/article/pii/S2589004224017243
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Table 2 Antibodies (for flow cytometry and immunoblotting assays).

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1. scibot 02 Aug 2024
  
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  Cas9
  
  DOI: 10.1038/s41598-021-82137-z
  
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nature.com/articles/s41598-021-82137-z/tables/2
Jul 2024
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A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

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1. scibot 31 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0247
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
Jun 2024
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Hypoxia-induced CTCF promotes EMT in breast cancer

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114367
  
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sciencedirect.com/science/article/pii/S2211124724006958
Apr 2024
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The chromatin remodeler CHD4 sustains Ewing Sarcoma cell survival by controlling global chromatin architecture

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/0008-5472.CAN-22-3950
  
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aacrjournals.org/cancerres/article/84/2/241/733111/The-Chromatin-Remodeler-CHD4-Sustains-Ewing
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Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse

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1. scibot 03 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101471
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
Mar 2024
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Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

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  DOI: 10.1016/j.celrep.2024.113849
  
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  DOI: 10.1016/j.celrep.2024.113849
  
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sciencedirect.com/science/article/pii/S2211124724001773
Feb 2024
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241-html.html

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1. scibot 23 Feb 2024
  
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52.53.155.43/ef1c2343cba3a29438101d6931686796493196a8/241-html.html
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Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing

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1. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113765
  
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sciencedirect.com/science/article/pii/S2211124724000937
Dec 2023
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Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery

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1. scibot 22 Dec 2023
  
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  DOI: 10.1038/s41467-023-43614-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10730884/
Nov 2023
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SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113434
  
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sciencedirect.com/science/article/pii/S2211124723014468
Apr 2023
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VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms

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  DOI: 10.1016/j.celrep.2023.112209
  
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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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1. scibot 19 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101015
  
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sciencedirect.com/science/article/pii/S2666379123001258
Nov 2022
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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

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1. scibot 19 Nov 2022
  
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  DOI: 10.1158/2767-9764.crc-22-0024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
Sep 2022
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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

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1. scibot 22 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111363
  
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sciencedirect.com/science/article/pii/S2211124722011950
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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1. scibot 02 Sep 2022
  
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  DOI: 10.1158/2159-8290.CD-21-1077
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
Aug 2022
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Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111181
  
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sciencedirect.com/science/article/pii/S2211124722009949
Jul 2022
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Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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  RRID:AB_2750916
  
  DOI: 10.1158/2767-9764.CRC-22-0024
  
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Mar 2022
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EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

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  DOI: 10.1158/2159-8290.CD-21-0385
  
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dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region

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  cell signalingAb #14697
  
  DOI: 10.1016/j.celrep.2022.110457
  
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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

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  DOI: 10.1016/j.molcel.2022.01.015
  
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Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

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  RRID:AB_2750916
  
  DOI: 10.1016/j.cell.2021.12.021
  
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Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis

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  DOI: 10.1016/j.stem.2021.11.001
  
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A genotype-phenotype screening system using conditionally immortalized immature dendritic cells

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  Cat# 14697
  
  DOI: 10.1016/j.xpro.2021.100732
  
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Untitled document

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Intron 1-Mediated Regulation of EGFR Expression In EGFR-Dependent Malignancies is Mediated by AP-1 and BET Proteins

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  Anti-Cas9
  
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May 2021
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Cas9 deactivation with photocleavable guide RNAs

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  DOI: 10.1016/j.molcel.2021.02.007
  
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Apr 2021
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A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

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  RRID:AB_2750916
  
  DOI: 10.1016/j.cell.2020.12.017
  
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Generation of an ELTD1 knockout human embryonic stem cell line by the iCRISPR/Cas9 system

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  RRID:AB_2750916
  
  DOI: 10.1016/j.scr.2021.102350
  
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Sep 2020
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YAP-depleted iPSC MUSIi012-A-2 maintained all normal stem cell characteristics

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  DOI: 10.1016/j.scr.2020.101723
  
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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

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  DOI: 10.7554/eLife.54993
  
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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

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  DOI: 10.1016/j.celrep.2020.01.052
  
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Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

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  RRID:AB_2750916
  
  DOI: 10.1016/j.ccell.2019.05.013
  
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Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

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  DOI: 10.1016/j.celrep.2019.11.065
  
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Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

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  RRID:AB_2750916
  
  DOI: 10.7554/eLife.46500
  
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BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

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  RRID:AB_2750916
  
  DOI: 10.1186/s12915-018-0617-1
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0617-1