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Dual blockade of PD-1 and NKG2A prevents NK cell senescence and reprograms the immunosuppressive microenvironment in pancreatic cancer

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  DOI: 10.1016/j.celrep.2026.117583
  
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sciencedirect.com/science/article/pii/S2211124726006613
Jun 2026
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Cyclin E modulates vulnerability to CDC7 kinase inhibition

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  DOI: 10.1038/s41389-026-00613-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13243581/
May 2026
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Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117409
  
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sciencedirect.com/science/article/pii/S2211124726004870
Mar 2026
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Protein Phosphatase 2 Is Required for Metastatic Dormancy and Is Regulated by Histone Demethylase KDM5A

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1. scibot 31 Mar 2026
  
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  DOI: 10.1002/mc.70109
  
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1-s2.0-S2589004226008801-main-html.html

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54.241.53.176/fe113be5e0479b752456981d23467ff50eff5555/1-s2.0-S2589004226008801-main-html.html
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JAK/STAT1-interferon-ISGylation networks in breast cancer resistance to inhibitors of FOXM1 and CDK4/6

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1. scibot 26 Mar 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13009525/
Feb 2026
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Dual roles of USP39 in stabilizing PB2 and orchestrating ribonucleoprotein assembly drive H5 influenza virus replication and pathogenicity

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sciencedirect.com/science/article/pii/S221112472600080X
Dec 2025
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Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy

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1. scibot 17 Dec 2025
  
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  DOI: 10.1016/j.xcrm.2025.102513
  
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sciencedirect.com:5037/science/article/pii/S2666379125005865
Nov 2025
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Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy

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  DOI: 10.1016/j.xcrm.2025.102448
  
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Sep 2025
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.07.024
  
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sciencedirect.com/science/article/pii/S1074761325003334
Jun 2025
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Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

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1. scibot 04 Jun 2025
  
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  DOI: 10.1038/s41598-025-03924-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12127464/
May 2025
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Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

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1. scibot 22 May 2025
  
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  DOI: 10.7554/eLife.96868
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12077877/
Apr 2025
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Lineage Tracing and Single-Cell RNA Sequencing Reveal a Common Transcriptional State in Breast Cancer Tumor–Initiating Cells Characterized by IFN/STAT1 Activity

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1. scibot 19 Apr 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-4022
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11997551/
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.006
  
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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-22-3009
  
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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
May 2024
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Hepatokine ITIH3 Protects Against Hepatic Steatosis by Downregulating Mitochondrial Bioenergetics and De Novo Lipogenesis

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1. scibot 03 May 2024
  
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  DOI: 10.1016/j.isci.2024.109709
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11059128/
Oct 2023
52.53.155.43 52.53.155.43

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

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1. scibot 14 Oct 2023
  
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  DOI: 10.1101/2023.08.08.552491
  
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52.53.155.43/9964c17a6d8fec4a6a270a6588b0b357cf73bf12/2023.08.08.552491v1.full-html.html
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Immune–epithelial cell cross-talk enhances antiviral responsiveness to SARS-CoV-2 in children

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1. scibot 13 Oct 2023
  
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  DOI: 10.15252/embr.202357912
  
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embopress.org/doi/full/10.15252/embr.202357912
Jul 2023
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Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

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1. scibot 19 Jul 2023
  
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  DOI: 10.1158/0008-5472.CAN-21-4309
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9938728/
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Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

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  DOI: 10.1016/j.xcrm.2023.101120
  
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Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH

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  DOI: 10.1016/j.isci.2023.107201
  
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May 2023
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

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1. scibot 26 May 2023
  
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  DOI: 10.1016/j.ccell.2023.04.018
  
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sciencedirect.com/science/article/pii/S1535610823001629
Nov 2022
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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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1. scibot 17 Nov 2022
  
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  RRID:AB_2773718
  
  DOI: 10.1016/j.molcel.2022.10.026
  
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sciencedirect.com/science/article/pii/S1097276522010541
Oct 2022
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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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1. scibot 26 Oct 2022
  
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  DOI: 10.1016/j.celrep.2022.111561
  
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Sep 2022
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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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  DOI: 10.1016/j.xcrm.2022.100744
  
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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1. scibot 02 Sep 2022
  
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  DOI: 10.1158/2159-8290.CD-21-1077
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
May 2022
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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  DOI: 10.1016/j.celrep.2022.110814
  
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sciencedirect.com/science/article/pii/S221112472200585X
Feb 2022
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

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  DOI: 10.1016/j.celrep.2022.110420
  
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pubmed.ncbi.nlm.nih.gov/35196494/
Jul 2021
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Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense

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1. scibot 31 Jul 2021
  
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  Anti-STAT1
  
  DOI: 10.1016/j.molcel.2019.11.003
  
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sciencedirect.com/science/article/pii/S1097276519308329
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Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

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  DOI: 10.1016/j.celrep.2021.109364
  
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sciencedirect.com/science/article/pii/S2211124721007622
May 2021
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Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population

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1. scibot 05 May 2021
  
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  DOI: 10.1016/j.devcel.2020.10.014
  
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sciencedirect.com/science/article/pii/S1534580720308340
Feb 2021
www.nature.com www.nature.com

Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

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1. scibot 25 Feb 2021
  
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  DOI: 10.1038/s41467-020-17139-y
  
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nature.com/articles/s41467-020-17139-y
Jan 2021
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Critical role of Syk-dependent STAT1 activation in innate antiviral immunity

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1. scibot 20 Jan 2021
  
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  RRID:AB_2773718
  
  DOI: 10.1016/j.celrep.2020.108627
  
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sciencedirect.com/science/article/pii/S2211124720316168
Sep 2020
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Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

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1. scibot 07 Sep 2020
  
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  RRID:AB_2773718
  
  DOI: 10.1016/j.celrep.2020.01.054
  
  Resource: (Cell Signaling Technology Cat# 8826, RRID:AB_2773718)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2773718
  
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  RRIDCUR:Validated RRID:AB_2773718
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RRID:AB_2773718

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scibot

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sciencedirect.com/science/article/pii/S2211124720300796
Jan 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression

1
1. scibot 13 Jan 2020
  
  in Public
  
  AB_2773718
  
  DOI: 10.1111/jnc.14912
  
  Resource: (Cell Signaling Technology Cat# 8826, RRID:AB_2773718)
  
  Curator: @Naa003
  
  SciCrunch record: AB_2773718
  
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  RRID:AB_2773718 RRIDCUR:Validated
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RRID:AB_2773718

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scibot

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onlinelibrary.wiley.com/doi/10.1111/jnc.14912
www.sciencedirect.com www.sciencedirect.com

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2773718
  
  DOI: 10.1016/j.immuni.2019.06.007
  
  Resource: (Cell Signaling Technology Cat# 8826, RRID:AB_2773718)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2773718
  
  What is this?
  
  RRID:AB_2773718 RRIDCUR:Validated
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RRID:AB_2773718

RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S1074761319302778