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Regulation of neutrophil homeostasis by the TNFAIP8 family of polarity proteins

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1. scibot 16 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117694
  
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sciencedirect.com/science/article/pii/S2211124726007722
Apr 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TREM2 sustains glucose metabolic homeostasis to drive antibacterial defense during sepsis

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1. scibot 18 Apr 2026
  
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  DOI: 10.1016/j.isci.2026.115415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13084338/
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Tailored Porous Bimetallic Nanozyme Platform for Full-Cycle Therapeutics of Intestinal Ischemia/Reperfusion

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1. scibot 02 Apr 2026
  
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  DOI: 10.1002/advs.202520748
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520748
Mar 2026
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Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia

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1. scibot 19 Mar 2026
  
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  DOI: 10.1007/s12264-026-01602-9
  
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link.springer.com/article/10.1007/s12264-026-01602-9
Feb 2026
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Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppressing GSDME-dependent pyroptosis

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cmet.2025.12.017
  
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sciencedirect.com/science/article/pii/S1550413125005480
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Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.chembiol.2026.01.003
  
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sciencedirect.com/science/article/pii/S2451945626000231
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Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors

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1. scibot 03 Feb 2026
  
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  DOI: 10.1016/j.immuni.2026.01.014
  
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sciencedirect.com/science/article/pii/S1074761326000361
Jan 2026
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Controlled pyroptosis of engineered macrophages enables biphasic antitumor via the release of oncolytic bacteria and inflammatory signals

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1. scibot 30 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116918
  
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sciencedirect.com/science/article/pii/S2211124725016900
Dec 2025
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Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling

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1. scibot 13 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116671
  
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sciencedirect.com:5037/science/article/pii/S2211124725014433
Nov 2025
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Circulating FABP5 released by dying macrophages function as a DAMP to exacerbate septic inflammation

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1. scibot 01 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116497
  
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sciencedirect.com/science/article/pii/S2211124725012689
Sep 2025
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A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.006
  
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sciencedirect.com/science/article/pii/S2451945625002594
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2025.08.28.672784v1.full-html.html

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1. scibot 06 Sep 2025
  
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  DOI: 10.1101/2025.08.28.672784
  
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52.53.155.43/ac7f1767c23c6666ccfc705d09859fa9a6162a49/2025.08.28.672784v1.full-html.html
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FABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116254
  
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sciencedirect.com/science/article/pii/S2211124725010253
Jul 2025
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The Hippo pathway kinase MST1 mediates a feedback loop to maintain NLRP3 inflammasome homeostasis

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116076
  
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sciencedirect.com/science/article/pii/S2211124725008472
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Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.019
  
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sciencedirect.com/science/article/pii/S1074761325003097
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S100a9 Aggravates Ischemia Brain Injury via Pyroptosis Pathway: A Potential Prognostic Biomarker and Therapeutic Target for Ischemic Stroke

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1. scibot 24 Jul 2025
  
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  DOI: 10.1111/jnc.70159
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70159
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.018
  
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sciencedirect.com/science/article/pii/S1074761325002870
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Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.stem.2025.06.009
  
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sciencedirect.com/science/article/pii/S1934590925002310
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A Potent Inhibitor of Caspase-8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases

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1. scibot 10 Jul 2025
  
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  DOI: 10.1021/acsbiomedchemau.4c00146
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12371506/
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Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-α

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1. scibot 02 Jul 2025
  
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  DOI: 10.1186/s40001-025-02702-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12211273/
Jun 2025
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Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.isci.2022.104050
  
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sciencedirect.com/science/article/pii/S2589004222003200
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PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity

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1. scibot 05 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115785
  
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sciencedirect.com/science/article/pii/S221112472500556X
May 2025
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s44318-025-00412-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
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Inflammasome signaling in astrocytes modulates hippocampal plasticity

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.007
  
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sciencedirect.com/science/article/pii/S1074761325001700
Apr 2025
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Lysosome positioning affects NLRP3 inflammasome activation

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1. scibot 03 Apr 2025
  
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  DOI: 10.1101/2025.03.21.644552
  
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52.53.155.43/5e725b42faf6f4894ebfb1897ac6165b04d7cac3/PDF-html.html
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Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.chom.2025.03.008
  
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sciencedirect.com/science/article/pii/S1931312825000915
Feb 2025
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115340
  
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Jan 2025
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Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection

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1. scibot 17 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115216
  
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Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway

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1. scibot 09 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115164
  
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Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

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  DOI: 10.1016/j.cell.2024.11.018
  
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Dec 2024
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1-s2.0-S2589004224028086-main-html.html

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1. scibot 19 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111581
  
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52.53.155.43/9f2a0ef4271b61fdfbdda27575922c2ba8834710/1-s2.0-S2589004224028086-main-html.html
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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.10.010
  
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sciencedirect.com/science/article/pii/S1074761324004904
Nov 2024
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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

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1. scibot 16 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.010
  
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sciencedirect.com/science/article/pii/S0092867424011589
Sep 2024
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FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114609
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398858/
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Activation of the NLRP1B inflammasome by caspase-8

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1. scibot 25 Sep 2024
  
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  RRID:AB_2783550
  
  DOI: 10.1038/s42003-024-06882-3
  
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Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis

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Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity

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CD14 is a decision-maker between Fas-mediated death and inflammation

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Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection

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Lyssavirus matrix protein inhibits NLRP3 inflammasome assembly by binding to NLRP3

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Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis

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NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation

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Tmem30a Protects Against Podocyte Injury Through Suppression of Pyroptosis

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Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

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Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke

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NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation

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Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment

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A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages

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A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis

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Effects of the Glucocorticoid-Mediated Mitochondrial Translocation of Glucocorticoid Receptors on Oxidative Stress and Pyroptosis in BV-2 Microglia

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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

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SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination

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Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

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The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

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Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms

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Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

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Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

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Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia

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Jun 2023
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Induced Neural Stem Cells Suppressed Neuroinflammation by Inhibiting the Microglial Pyroptotic Pathway in Intracerebral Hemorrhage Rats

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Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

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Whole-genome CRISPR screen identifies RAVER1 regulates RIPK1-mediated inflammatory cell death, PANoptosis

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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response

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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

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Engineer a double team of short-lived and glucose-sensing bacteria for cancer eradication

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Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

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CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout

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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

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BPS Publications

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Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation

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Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis

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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

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Gasdermin D pore-forming activity is redox-sensitive

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The NLRP1 and CARD8 inflammasomes detect reductive stress

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Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

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Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins

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Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells

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Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways

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STING mediates neuroinflammatory response by activating NLRP3-related pyroptosis in severe traumatic brain injury

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A TLR4-independent critical role for CD14 in intracellular LPS sensing

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Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon

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Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

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Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection

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Shigella OspC3 suppresses murine cytosolic LPS sensing

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Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties

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Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense

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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

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Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

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Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock

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Itaconate confers tolerance to late NLRP3 inflammasome activation

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A comprehensive guide to studying inflammasome activation and cell death

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Dec 2020
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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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ncbi.nlm.nih.gov/pmc/articles/PMC7674074/
Nov 2020
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LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

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RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly

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Oct 2020
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Activation of the CARD8 Inflammasome Requires a Disordered Region

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Sep 2020
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A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling

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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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  DOI: 10.1016/j.cell.2020.03.040
  
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

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  DOI: 10.1016/j.immuni.2020.07.004
  
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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

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  DOI: 10.1016/j.celrep.2020.02.025
  
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium

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  DOI: 10.1016/j.celrep.2020.107967
  
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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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  DOI: 10.1016/j.immuni.2020.02.002
  
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Jan 2020
iovs.arvojournals.org iovs.arvojournals.org

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-trans Retinal

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  DOI: 10.1167/iovs.18-26360
  
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Untitled document

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  DOI: 10.1016/j.immuni.2019.04.017
  
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