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Distinct autophagy impairment mechanisms of huntingtin aggregates with different polyQ lengths

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1. scibot 07 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.010
  
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sciencedirect.com/science/article/pii/S2451945626001029
Mar 2026
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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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  DOI: 10.1016/j.celrep.2026.117134
  
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sciencedirect.com/science/article/pii/S2211124726002123
Feb 2026
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Proteasome activity maintains cell-type-specific gene expression

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  DOI: 10.1016/j.celrep.2026.116973
  
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sciencedirect.com/science/article/pii/S2211124726000513
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1-s2.0-S2589004226002919-main-html.html

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pmc.ncbi.nlm.nih.gov/articles/PMC12936848/
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Sleep disturbance triggers aberrant activation of vagus circuitry and induces intestinal stem cell dysfunction

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  DOI: 10.1016/j.stem.2026.01.002
  
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sciencedirect.com/science/article/pii/S1934590926000251
Jan 2026
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B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity

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  DOI: 10.1016/j.ccell.2025.12.011
  
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sciencedirect.com/science/article/pii/S1535610825005458
Dec 2025
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Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.010
  
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sciencedirect.com:5037/science/article/pii/S0092867425013066
Oct 2025
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Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells

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  DOI: 10.1016/j.celrep.2025.116448
  
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sciencedirect.com/science/article/pii/S2211124725012197
Sep 2025
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UBE2T-mediated HP1α ubiquitination enhances nucleolar function and promotes the progression of IDH1/TP53-mutant glioma

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  DOI: 10.1158/1078-0432.CCR-25-0261
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12434397/
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Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity

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sciencedirect.com/science/article/pii/S2666379125004069
Aug 2025
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BPS Publications

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1. scibot 27 Aug 2025
  
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  DOI: 10.1111/bph.70175
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70175
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TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease

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  DOI: 10.1016/j.celrep.2025.116091
  
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sciencedirect.com/science/article/pii/S2211124725008629
Jun 2025
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.029
  
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sciencedirect.com/science/article/pii/S0092867425006166
May 2025
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Covalent inhibition of Plasmodium falciparum Ubc13 impairs global protein synthesis

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.isci.2025.112545
  
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sciencedirect.com/science/article/pii/S2589004225008065
Feb 2025
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HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115339
  
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sciencedirect.com/science/article/pii/S221112472500110X
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Inhibition of SCFKDM2A/USP22-dependent nuclear β-catenin ubiquitylation mediates cerebral ischemic tolerance

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1. scibot 13 Feb 2025
  
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  DOI: 10.1038/s42003-025-07644-5
  
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link.springer.com/article/10.1038/s42003-025-07644-5
Sep 2024
52.53.155.43 52.53.155.43

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

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1. scibot 05 Sep 2024
  
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  DOI: 10.1101/2024.07.26.605278
  
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52.53.155.43/76e736f0a40c1a2ebb10a21ddca6aa06b484cb52/2024.07.26.605278v1.full-html.html
Jul 2024
www.cell.com www.cell.com

DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114368
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00696-X
Jun 2024
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USP7 upregulated by TGF-β1 promotes ferroptosis via inhibiting LATS1-YAP axis in sepsis-induced acute lung injury

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1. scibot 07 Jun 2024
  
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52.53.155.43/42e7a96fcaf0feb77214aace44853c4bba6f43b1/1-s2.0-S2589004224008897-main-html.html
May 2024
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Insights from multi-omic modeling of neurodegeneration in xeroderma pigmentosum using an induced pluripotent stem cell system

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  DOI: 10.1016/j.celrep.2024.114243
  
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eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer

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1. scibot 24 May 2024
  
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  DOI: 10.1126/scisignal.adh4475
  
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science.org/doi/10.1126/scisignal.adh4475
Apr 2024
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Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis

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1. scibot 23 Apr 2024
  
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sciencedirect.com/science/article/pii/S0925443924001728
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Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling

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  DOI: 10.1016/j.xcrm.2024.101510
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148513/
Feb 2024
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hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility

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  DOI: 10.1016/j.celrep.2024.113769
  
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circCD2AP promotes epithelial mesenchymal transition and stemness in bladder cancer by regulating FOXQ1/USP21 axis

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  DOI: 10.1016/j.isci.2023.108447
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10827552/
Nov 2023
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A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment

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  DOI: 10.1016/j.xcrm.2023.101286
  
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sciencedirect.com/science/article/pii/S2666379123004809
Oct 2023
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AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis

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cell.com/cell-reports/abstract/S2211-1247(23)01121-X
Jul 2023
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Super-resolution imaging unveils the self-replication of tau aggregates upon seeding

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  DOI: 10.1016/j.celrep.2023.112725
  
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Jun 2023
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USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis

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  DOI: 10.1158/1541-7786.MCR-22-0552
  
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aacrjournals.org/mcr/article/21/6/578/726510/USP10-Regulates-ZEB1-Ubiquitination-and-Protein
Mar 2023
europepmc.org europepmc.org

UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS

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  DOI: 10.1016/j.celrep.2023.112272
  
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europepmc.org/article/med/36943869
Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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  DOI: 10.1016/j.celrep.2022.111834
  
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sciencedirect.com/science/article/pii/S2211124722017260
Apr 2022
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An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity

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  DOI: 10.1016/j.celrep.2022.110656
  
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cell.com/cell-reports/fulltext/S2211-1247(22)00408-9
Dec 2021
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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

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1. scibot 28 Dec 2021
  
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  DOI: 10.1016/j.xcrm.2021.100455
  
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sciencedirect.com/science/article/pii/S2666379121003232
Aug 2021
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Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE

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1. scibot 16 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.021
  
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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation

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1. scibot 06 Aug 2021
  
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  DOI: 10.1016/j.molcel.2021.07.013
  
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  Curator: @scibot
  
  SciCrunch record: RRID:AB_2783797
  
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  RRID:AB_2783797
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RRID:AB_2783797

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scibot

URL

sciencedirect.com/science/article/pii/S1097276521005827
Feb 2021
www.sciencedirect.com www.sciencedirect.com

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

1
1. scibot 24 Feb 2021
  
  in Public
  
  RRID:AB_2783797
  
  DOI: 10.1016/j.celrep.2020.01.015
  
  Resource: (Abcam Cat# ab140601, RRID:AB_2783797)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2783797
  
  What is this?
  
  RRID:AB_2783797
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RRID:AB_2783797

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scibot

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sciencedirect.com/science/article/pii/S2211124720300243
Nov 2020
www.sciencedirect.com www.sciencedirect.com

Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade

1
1. scibot 24 Nov 2020
  
  in Public
  
  RRID:AB_2783797
  
  DOI: 10.1016/j.chembiol.2020.10.008
  
  Resource: (Abcam Cat# ab140601, RRID:AB_2783797)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2783797
  
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  RRIDCUR:Validated RRID:AB_2783797
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RRID:AB_2783797

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2451945620304244
Sep 2020
www.sciencedirect.com www.sciencedirect.com

OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1

1
1. scibot 06 Sep 2020
  
  in Public
  
  RRID:AB_2783797
  
  DOI: 10.1016/j.celrep.2020.01.015
  
  Resource: (Abcam Cat# ab140601, RRID:AB_2783797)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2783797
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2783797
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RRID:AB_2783797

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S2211124720300243
Jan 2020
www.sciencedirect.com www.sciencedirect.com

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_2783797
  
  DOI: 10.1016/j.molcel.2019.09.009
  
  Resource: (Abcam Cat# ab140601, RRID:AB_2783797)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2783797
  
  What is this?
  
  RRID:AB_2783797 RRIDCUR:Validated
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RRID:AB_2783797

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S109727651930694X