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Sep 2025
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Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.08.008
  
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sciencedirect.com/science/article/pii/S1074761325003711
Apr 2025
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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115605
  
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sciencedirect.com/science/article/pii/S2211124725003766
Dec 2024
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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115104
  
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sciencedirect.com/science/article/pii/S2211124724014554
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Single-cell analysis reveals host S phase drives large T antigen expression during BK polyomavirus infection

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1. scibot 11 Dec 2024
  
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  DOI: 10.1371/journal.ppat.1012663
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11620372/
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
Jun 2024
www.cell.com www.cell.com

CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

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1. scibot 29 Jun 2024
  
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  DOI: 10.1016/j.isci.2024.109978
  
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cell.com/iscience/abstract/S2589-0042(24)01200-8
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome

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1. scibot 02 Feb 2024
  
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  DOI: 10.1186/s13578-024-01198-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

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1. scibot 17 Jun 2023
  
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  DOI: 10.1016/j.molcel.2022.12.004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
May 2023
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Replication stress impairs chromosome segregation and preimplantation development in human embryos

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1. scibot 05 May 2023
  
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  DOI: 10.1016/j.cell.2022.06.028
  
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sciencedirect.com/science/article/pii/S0092867422007802
www.nature.com www.nature.com

Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations

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1. scibot 05 May 2023
  
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  AB_2783865
  
  DOI: 10.1038/s41419-022-05073-4
  
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nature.com/articles/s41419-022-05073-4
Jun 2022
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Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

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1. scibot 30 Jun 2022
  
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  DOI: 10.1016/j.devcel.2022.06.003
  
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sciencedirect.com/science/article/pii/S1534580722004129
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A function for Ataxia telangiectasia and Rad3-related (ATR) kinase in cytokinetic abscission

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1. scibot 17 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104536
  
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sciencedirect.com/science/article/pii/S2589004222008070
Apr 2022
aacrjournals.org aacrjournals.org

DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models

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1. scibot 05 Apr 2022
  
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  DOI: 10.1158/1535-7163.MCT-21-0554
  
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aacrjournals.org/mct/article/21/4/635/689570/DS-7300a-a-DNA-Topoisomerase-I-Inhibitor-DXd-Based
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

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1. scibot 12 Feb 2022
  
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  DOI: 10.7554/eLife.68677
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8824475/
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

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1. scibot 17 Dec 2021
  
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  DOI: 10.7554/eLife.70691
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8670743/
Feb 2021
www.nature.com www.nature.com

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

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1. scibot 09 Feb 2021
  
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  RRID:AB_2783865
  
  DOI: 10.1038/s41418-020-00733-4
  
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  Curator: @evieth
  
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  RRID:AB_2783865 RRIDCUR:Validated
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nature.com/articles/s41418-020-00733-4
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers

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1. scibot 28 Jan 2021
  
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  RRID:AB_2783865
  
  DOI: 10.3390/md19010041
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7831112/
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ATR expands embryonic stem cell fate potential in response to replication stress

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1. scibot 14 Sep 2020
  
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  RRID:AB_2783865
  
  DOI: 10.7554/eLife.54756
  
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  RRID:AB_2783865 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7067586/
Jan 2020
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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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1. scibot 13 Jan 2020
  
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  RRID:AB_2783865
  
  DOI: 10.1016/j.cels.2019.11.001
  
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  Curator: @ethanbadger
  
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  RRID:AB_2783865 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2405471219303874
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2783865
  
  DOI: 10.1016/j.molcel.2019.04.024
  
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  RRID:AB_2783865 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519303168