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SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma

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  DOI: 10.1016/j.celrep.2026.117223
  
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Apr 2026
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Bench-to-Bedside Evaluation of Sulforaphane/BroccoMax® on Fatty Acid Synthesis in Prostate Cancer

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  DOI: 10.1158/1940-6207.CAPR-25-0488
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13034680/
Mar 2026
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Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

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  DOI: 10.1016/j.stem.2026.02.009
  
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Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia

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Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis

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Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3

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  DOI: 10.64898/2026.02.26.708348
  
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Feb 2026
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Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability

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Hypoxia restores the acidosis-induced inhibition of cancer cell dissemination

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The Microbial Bile Acid Metabolite 3-oxo-LCA Inhibits Colorectal Cancer Progression

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Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer

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Jan 2026
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Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma

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1. scibot 22 Jan 2026
  
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PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease

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1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116811
  
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PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation

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1. scibot 06 Jan 2026
  
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  DOI: 10.1038/s41388-025-03670-z
  
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nature.com/articles/s41388-025-03670-z
Dec 2025
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3D post-implantation co-culture of human embryo and endometrium

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.stem.2025.12.002
  
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Modeling human embryo implantation in vitro

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  DOI: 10.1016/j.cell.2025.10.027
  
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sciencedirect.com/science/article/pii/S0092867425012322
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circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116659
  
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sciencedirect.com:5037/science/article/pii/S2211124725014317
Nov 2025
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A Hybrid compound H93 treats prostate cancer by directly binding UHRF1 and promoting protein dimerization

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1. scibot 21 Nov 2025
  
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  DOI: 10.1038/s42004-025-01744-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12627547/
Oct 2025
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Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21

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1. scibot 23 Oct 2025
  
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  DOI: 10.1101/2025.10.16.681972
  
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Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma

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1. scibot 07 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113456
  
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Aug 2025
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Immune-Competent 3D Bioengineered Colons for Functional Interrogation of Neuroinflammation-Induced Colonic Dysmotility

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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

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  DOI: 10.1016/j.ccell.2025.07.006
  
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The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi

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  DOI: 10.1016/j.devcel.2025.07.010
  
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Jun 2025
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1-s2.0-S2589004225011216-main-html.html

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52.53.155.43/2abcfe5fe766e4300373f461f78d375160fe8922/1-s2.0-S2589004225011216-main-html.html
Apr 2025
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1-s2.0-S2589004225005346-main-html.html

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Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups

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Feb 2025
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TGF-β1-mediated intercellular signaling fuels cooperative cellular invasion

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  DOI: 10.1016/j.celrep.2025.115315
  
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Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation

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Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions

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  DOI: 10.1016/j.stem.2025.01.001
  
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Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury

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Oct 2024
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The chromodomain protein CDYL confers forebrain identity to human cortical organoids by inhibiting neuronatin

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Sep 2024
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Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids

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  DOI: 10.1101/2024.09.03.611030
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11398411/
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CircPOLA2 sensitizes non-small cell lung cancer cells to ferroptosis and suppresses tumorigenesis via the Merlin-YAP signaling pathway

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  DOI: 10.1016/j.isci.2024.110832
  
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Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.celrep.2021.108788
  
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EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

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  RRID:AB_2715512
  
  DOI: 10.1016/j.ccell.2019.12.015
  
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OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium

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Aspirin Inhibition of Group VI Phospholipase A2 Induces Synthetic Lethality in AAM Pathway Down-Regulated Gingivobuccal Squamous Carcinoma

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Jun 2024
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Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1

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Development of a PAK4-targeting PROTAC for renal carcinoma therapy: concurrent inhibition of cancer cell proliferation and enhancement of immune cell response

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Repurposing AS1411 for constructing ANM-PROTACs

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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells

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Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation

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Nov 2023
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Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

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Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer

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Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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Jul 2023
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A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

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Targeting fatty acid reprogramming suppresses CARM1-expressing ovarian cancer

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ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression

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Modeling human ectopic pregnancies with trophoblast and vascular organoids

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p53-independent tumor suppression by cell-cycle arrest via CREB/ATF transcription factor OASIS

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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction

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Sustained oncogenic signaling in the cytostatic state enables targeting of non-proliferating persistent cancer cells

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Feb 2023
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STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice

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Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET

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In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis

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The human placenta shapes the phenotype of decidual macrophages

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Anlotinib Suppressed Ovarian Cancer Progression via Inducing G2/M Phase Arrest and Apoptosis

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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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Spatial epitope barcoding reveals clonal tumor patch behaviors

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CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression

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GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A

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PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

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Aug 2022
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can-21-2908-html.html

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GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming

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METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma

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Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens

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PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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Oct 2021
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ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells

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Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers

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  DOI: 10.1158/0008-5472.CAN-21-1545
  
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Aug 2021
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The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway

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A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

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ncbi.nlm.nih.gov/pmc/articles/PMC8321552/
Jul 2021
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Necroptotic virotherapy of oncolytic alphavirus M1 cooperated with Doxorubicin displays promising therapeutic efficacy in TNBC

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Lower androgen levels promote abnormal cartilage development in female patients with adolescent idiopathic scoliosis

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  DOI: 10.21037/atm-20-3171
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8246169/
May 2021
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Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells

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  DOI: 10.7717/peerj.11388
  
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Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

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Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma

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  KI67
  
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Feb 2021
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Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress

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  anti-Ki67
  
  DOI: 10.1038/s42255-020-00325-z
  
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nature.com/articles/s42255-020-00325-z
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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  DOI: 10.1111/bph.14985
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14985
Nov 2020
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p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound

1
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  anti-Ki67
  
  DOI: 10.1007/s10571-020-01006-x
  
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FEBS Press

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  DOI: 10.1002/1878-0261.12820
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12820
cancerci.biomedcentral.com cancerci.biomedcentral.com

Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity

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  RRID:AB_2797703
  
  DOI: 10.1186/s12935-020-01598-w
  
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cancerci.biomedcentral.com/article/10.1186/s12935-020-01598-w
Oct 2020
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Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

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cell.com/cell-reports/abstract/S2211-1247(20)31275-4
Sep 2020
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Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer

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  DOI: 10.1038/s41388-020-01416-7
  
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AMPK-Regulated Astrocytic Lactate Shuttle Plays a Non-Cell-Autonomous Role in Neuronal Survival

1
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pubmed.ncbi.nlm.nih.gov/32877674/
Jan 2020
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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

1
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  DOI: 10.1016/j.cmet.2019.06.014
  
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sciencedirect.com/science/article/pii/S1550413119303171
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Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development

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  DOI: 10.1016/j.devcel.2019.09.008
  
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sciencedirect.com/science/article/pii/S1534580719307373

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