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Polymerase iota coordinates adaptation to replication stress in BRCA2-deficient mammary epithelial cells

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1. scibot 11 Oct 2026
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.isci.2026.117830
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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sciencedirect.com/science/article/pii/S2589004226032116
Jul 2026
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Disruption of microhomology-mediated end joining in Ewing sarcoma

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1. scibot 23 Jul 2026
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.molcel.2026.06.038
  
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sciencedirect.com/science/article/pii/S109727652600451X
aacrjournals.org aacrjournals.org

A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition

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1. scibot 11 Jul 2026
  
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  RRID:AB_2797730
  
  DOI: 10.1158/0008-5472.CAN-24-4096
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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aacrjournals.org/cancerres/article/85/18/3490/764450/A-Peptide-Based-PROTAC-Degrader-of-BRCA2
Mar 2026
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miR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma

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1. scibot 10 Mar 2026
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.isci.2026.115077
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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sciencedirect.com/science/article/pii/S2589004226004529
Feb 2026
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

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1. scibot 05 Feb 2026
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.celrep.2026.116941
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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sciencedirect.com/science/article/pii/S2211124726000197
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of Aberrantly Overexpressed Polo-like Kinase 4 Is a Potential Effective Treatment for DNA Damage Repair–Deficient Uterine Leiomyosarcoma

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1. scibot 05 Sep 2024
  
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  RRID:AB_2797730
  
  DOI: 10.1158/1078-0432.CCR-23-3720
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369621/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks

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1. scibot 21 Aug 2024
  
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  AB_2797730
  
  DOI: 10.1038/s41388-024-03094-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315672/
Jul 2024
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A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

1
1. scibot 14 Jul 2024
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.isci.2024.110180
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11238136/
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ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines

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1. scibot 12 Jul 2024
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.celrep.2024.114433
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00762-9
Apr 2024
www.nature.com www.nature.com

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

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1. scibot 03 Apr 2024
  
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  RRID:AB_2797730
  
  DOI: 10.1038/s41467-024-47069-y
  
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nature.com/articles/s41467-024-47069-y
Apr 2023
aacrjournals.org aacrjournals.org

Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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1. scibot 21 Apr 2023
  
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  RRID:AB_2797730
  
  DOI: 10.1158/2326-6066.CIR-22-0056
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
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aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
May 2022
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Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor

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1. scibot 12 May 2022
  
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  RRID:AB_2797730
  
  DOI: 10.1016/j.celrep.2022.110771
  
  Resource: (Cell Signaling Technology Cat# 10741, RRID:AB_2797730)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2797730
  
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sciencedirect.com/science/article/pii/S2211124722005356