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Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING

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  DOI: 10.1016/j.celrep.2025.116745
  
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sciencedirect.com:5037/science/article/pii/S2211124725015177
Nov 2025
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The lipid droplet protein DHRS3 is a regulator of melanoma cell state

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  DOI: 10.1111/pcmr.13208
  
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Oct 2025
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Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma

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Sep 2025
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A role for CASM in the repair of damaged Golgi architecture

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Aug 2025
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Extracellular vesicle manufacture via FACTORY: fully automated collection technology and optimum machinery for clinical translational applications

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Jun 2025
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Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging

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Feb 2025
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BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease

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A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation

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Dec 2024
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

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Sep 2024
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Zika virus NS3 drives the assembly of a viroplasm-like structure

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Aug 2024
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Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors

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Jul 2024
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TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging

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ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
Jun 2024
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Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts

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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

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May 2024
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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

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ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
Apr 2024
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Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

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ncbi.nlm.nih.gov/pmc/articles/PMC11030420/
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Trafficking of Connexin36 (Cx36) in the early secretory pathway

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1. scibot 18 Apr 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10996632/
Jan 2024
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Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection

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sciencedirect.com/science/article/pii/S2589004224000221
Oct 2023
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MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

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cell.com/cell-reports/abstract/S2211-1247(23)01034-3
Jun 2023
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The intracellular C-terminal domain of mGluR6 contains ER retention motifs

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Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage

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  DOI: 10.1126/sciadv.adf6600
  
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Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage

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May 2023
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Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity

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Apr 2023
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ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion

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Feb 2023
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HRS regulates small extracellular vesicle PD-L1 secretion and is associated with anti-PD-1 treatment efficacy

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  DOI: 10.1158/2326-6066.CIR-22-0277
  
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aacrjournals.org/cancerimmunolres/article/11/2/228/716209/HRS-Regulates-Small-Extracellular-Vesicle-PD-L1
Jan 2023
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Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks

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SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2

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Dec 2022
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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

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Sep 2022
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Target protein localization and its impact on PROTAC-mediated degradation

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Aug 2022
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STK25 inhibits PKA signaling by phosphorylating PRKAR1A

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Jul 2022
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FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia

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Aug 2021
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Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

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1. scibot 25 Aug 2021
  
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  DOI: 10.7554/eLife.65417
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8373376/
Jul 2021
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Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

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1. scibot 30 Jul 2021
  
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  DOI: 10.1021/acsnano.9b04397
  
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Delivering progranulin to neuronal lysosomes protects against excitotoxicity

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May 2021
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ELAVL1 primarily couples mRNA stability with the 3′ UTRs of interferon-stimulated genes

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  DOI: 10.1016/j.celrep.2021.109178
  
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Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells

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  DOI: 10.1126/sciadv.abe8349
  
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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

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  DOI: 10.1016/j.molcel.2021.03.001
  
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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

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  DOI: 10.1016/j.devcel.2020.11.007
  
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Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells

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  DOI: 10.1016/j.cmet.2020.10.025
  
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

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  DOI: 10.1016/j.chom.2020.11.003
  
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Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies

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APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

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Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis

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Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

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Transferrin Receptor Is a Specific Ferroptosis Marker

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The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

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Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

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JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

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Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASP

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Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy

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Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex

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  DOI: 10.1016/j.cub.2019.07.021
  
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A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

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