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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.004
  
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sciencedirect.com/science/article/pii/S2451945625002557
Aug 2025
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A preclinical model for the identification of therapeutically active transgenes in local cancer immunotherapy

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1. scibot 21 Aug 2025
  
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  DOI: 10.1080/2162402X.2025.2543620
  
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tandfonline.com/doi/full/10.1080/2162402X.2025.2543620
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Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.013
  
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A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4774
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.008
  
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sciencedirect.com/science/article/pii/S1074761325003176
Jul 2025
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CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo

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1. scibot 17 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.011
  
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Jun 2025
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BCL2 drives castration resistance in castration-sensitive prostate cancer by orchestrating reciprocal crosstalk between oncogenic pathways

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115779
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00550-9
May 2025
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Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.027
  
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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.020
  
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sciencedirect.com/science/article/pii/S1074761325001839
Mar 2025
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1-s2.0-S2352345X25000529-main-html.html

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.jcmgh.2025.101511
  
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52.53.155.43/fef402626328406d2d25d2741266ecc98ccfdd75/1-s2.0-S2352345X25000529-main-html.html
Feb 2025
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An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities

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1. scibot 15 Feb 2025
  
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  DOI: 10.1186/s13046-025-03319-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11818027/
Jan 2025
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1-s2.0-S2589004225000641-main-html.html

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.isci.2025.111804
  
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52.53.155.43/bb0038ac4731f895cea6a9b8553ebcc516f55d21/1-s2.0-S2589004225000641-main-html.html
Sep 2024
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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

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1. scibot 04 Sep 2024
  
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  AB_2798898
  
  DOI: 10.1016/j.xcrm.2024.101711
  
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sciencedirect.com/science/article/pii/S2666379124004324
Jul 2024
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Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.06.001
  
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cell.com/cancer-cell/abstract/S1535-6108(24)00226-5
Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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1. scibot 03 Apr 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-1003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10592192/
Mar 2024
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ΔNp63 regulates MDSC survival and metabolism in triple-negative breast cancer

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1. scibot 22 Mar 2024
  
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  RRID:AB_2798898
  
  DOI: 10.1016/j.isci.2024.109366
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10951988/
Jan 2024
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Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

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1. scibot 20 Jan 2024
  
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  RRID:AB_2798898
  
  DOI: 10.1158/0008-5472.CAN-23-1448
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10790129/
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Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy

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1. scibot 09 Jan 2024
  
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  RRID:AB_2798898
  
  DOI: 10.1016/j.xcrm.2023.101355
  
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sciencedirect.com/science/article/pii/S2666379123005724
Dec 2023
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The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.immuni.2023.11.002
  
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sciencedirect.com/science/article/pii/S1074761323004831
Nov 2023
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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.devcel.2023.10.010
  
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sciencedirect.com/science/article/pii/S1534580723005518
Oct 2023
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.ccell.2023.09.001
  
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sciencedirect.com/science/article/pii/S1535610823003185
52.53.155.43 52.53.155.43

SSRN-id4540281-html.html

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1. scibot 07 Oct 2023
  
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  DOI: 10.2139/ssrn.4540281
  
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52.53.155.43/72bad1538c1a67187d728f0cf48027e5fa4142ed/SSRN-id4540281-html.html
Aug 2023
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A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells

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1. scibot 16 Aug 2023
  
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  RRID:AB_2798898
  
  DOI: 10.1016/j.xcrm.2023.101154
  
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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

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1. scibot 04 Aug 2023
  
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  RRID:AB_2798898
  
  DOI: 10.1016/j.ccell.2021.02.007
  
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sciencedirect.com/science/article/pii/S1535610821001094
Jun 2023
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Spatially resolved multi-omics single-cell analyses inform mechanisms of immune-dysfunction in pancreatic cancer

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1. scibot 16 Jun 2023
  
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  DOI: 10.1053/j.gastro.2023.05.036
  
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52.53.155.43/71ccfaec92c7763faf07cdf10a5de07b1aba97a1/1-s2.0-S0016508523008107-main-html.html
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The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response

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1. scibot 07 Jun 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-2485
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10236158/
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Activating an Adaptive Immune Response with a Telomerase-mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma

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1. scibot 03 Jun 2023
  
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  DOI: 10.1158/1535-7163.MCT-23-0039
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10233358/
52.53.155.43 52.53.155.43

mct-23-0039-html.html

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  DOI: 10.1158/1535-7163.mct-23-0039
  
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52.53.155.43/2e399e27445b3309b8dca3d6b15c5701e7dc6c5e/mct-23-0039-html.html
May 2023
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Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism

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1. scibot 26 May 2023
  
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  DOI: 10.1016/j.chembiol.2023.05.003
  
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sciencedirect.com/science/article/pii/S2451945623001265
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Immune mechanisms shape the clonal landscape during early progression of prostate cancer

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1. scibot 06 May 2023
  
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  DOI: 10.1016/j.devcel.2023.04.010
  
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sciencedirect.com/science/article/pii/S1534580723001806
Apr 2023
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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma

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1. scibot 12 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101009
  
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sciencedirect.com/science/article/pii/S2666379123001192
Dec 2022
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can-22-1046-html.html

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1. scibot 01 Dec 2022
  
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  DOI: 10.1158/0008-5472.can-22-1046
  
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52.53.155.43/31121aea6deac1c0e5bfa6acfce4eeee5d0658c1/can-22-1046-html.html
Nov 2022
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Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy

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1. scibot 16 Nov 2022
  
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  RRID:AB_2798898
  
  DOI: 10.1016/j.ebiom.2022.104353
  
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sciencedirect.com/science/article/pii/S2352396422005357
Sep 2022
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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1. scibot 02 Sep 2022
  
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  DOI: 10.1158/2159-8290.CD-21-1077
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
Aug 2022
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Evaluation of the role of the immune system response following minibeam radiation therapy

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.ijrobp.2022.08.011
  
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sciencedirect.com/science/article/pii/S0360301622031066
Jul 2022
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Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer

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1. scibot 27 Jul 2022
  
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  DOI: 10.1016/j.ccell.2022.06.011
  
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sciencedirect.com/science/article/pii/S1535610822002756
Nov 2021
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mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

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1. scibot 24 Nov 2021
  
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  DOI: 10.7554/eLife.69015
  
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elifesciences.org/articles/69015
Apr 2021
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Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis

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1. scibot 30 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.12.016
  
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Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.ccell.2021.02.007
  
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Feb 2021
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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

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1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.celrep.2020.01.008
  
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cell.com/cell-reports/abstract/S2211-1247(20)30017-6
Sep 2020
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Soluble recombinant human thrombomodulin suppresses inflammation-induced gastrointestinal tumor growth in a murine peritonitis model

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1. scibot 26 Sep 2020
  
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  DOI: 10.1007/s11010-020-03872-x
  
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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.01.011
  
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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1. scibot 14 Sep 2020
  
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  DOI: 10.1016/j.ccell.2019.12.006
  
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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

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1. scibot 08 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.01.008
  
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cell.com/cell-reports/abstract/S2211-1247(20)30017-6