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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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  3. Jun 2024
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    The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity
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    Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
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  6. May 2024
  7. 52.53.155.43 52.53.155.43
    cir-23-1078-html.html
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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    Viral mimicry and memory deficits upon microglial deletion of ATRX
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    biorxiv.org/content/10.1101/2024.05.07.592875v1
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    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
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    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2666379124002520
  12. Apr 2024
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    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2666379124001976
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    Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers
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    Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    sciencedirect.com/science/article/pii/S2211124724004169
  17. Mar 2024
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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  19. Feb 2024
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
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  21. Jan 2024
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    CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise
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    sciencedirect.com/science/article/pii/S2211124723016376
  23. Nov 2023
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
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    Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
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  26. Oct 2023
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    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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  28. Aug 2023
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    4-Octyl itaconate restricts STING activation by blocking its palmitoylation
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    sciencedirect.com/science/article/pii/S2211124723010513
  30. Jul 2023
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    Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy
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  32. Jun 2023
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    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    sciencedirect.com/science/article/pii/S2589004223011677
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    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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    sciencedirect.com/science/article/pii/S1535610823001733
  36. May 2023
  37. journals.aai.org journals.aai.org
    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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      DOI: 10.4049/jimmunol.2200351

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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
  38. Mar 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10035514/
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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    sciencedirect.com/science/article/pii/S2211124723003200
  41. Feb 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model
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      DOI: 10.3389/fmolb.2023.1058825

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    ncbi.nlm.nih.gov/pmc/articles/PMC9893022/
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    Spermine enhances antiviral and anticancer responses by stabilizing DNA binding with the DNA sensor cGAS
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  44. Dec 2022
  45. www.embopress.org www.embopress.org
    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    embopress.org/doi/10.15252/embj.2022111961
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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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    sciencedirect.com/science/article/pii/S2211124722016527
  47. Nov 2022
  48. www.sciencedirect.com www.sciencedirect.com
    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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      DOI: 10.1016/j.neuron.2022.10.028

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    sciencedirect.com/science/article/pii/S0896627322009618
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    Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy
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    sciencedirect.com/science/article/pii/S2211124722014474
  50. Sep 2022
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease
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      DOI: 10.1016/j.isci.2022.105145

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    ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
  52. Jul 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
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    sciencedirect.com/science/article/pii/S1074761322002801
  54. Jun 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SETDB1–TRIM28 complex suppresses antitumor immunity
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      DOI: 10.1158/2326-6066.CIR-21-0754

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    ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
  56. May 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Protocol to induce and assess cGAS-STING pathway activation in vitro
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      DOI: 10.1016/j.xpro.2022.101384

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    sciencedirect.com/science/article/pii/S2666166722002647
  58. Jan 2022
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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      DOI: 10.1016/j.cmet.2021.12.007

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    sciencedirect.com/science/article/pii/S1550413121006264
  60. Nov 2021
  61. www.sciencedirect.com www.sciencedirect.com
    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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    sciencedirect.com/science/article/pii/S1074761321004106
  62. Aug 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA
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    1. scibot 25 Aug 2021
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2021.109537

      Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)

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    sciencedirect.com/science/article/pii/S2211124721009712
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    1. scibot 15 Aug 2021
      RRID:AB_2799008

      DOI: 10.1002/advs.202100779

      Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)

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    onlinelibrary.wiley.com/doi/10.1002/advs.202100779
  65. Jul 2021
  66. www.nature.com www.nature.com
    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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    1. scibot 31 Jul 2021
      31659

      DOI: 10.1038/s41586-021-03762-2

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    nature.com/articles/s41586-021-03762-2
  67. May 2021
  68. www.sciencedirect.com www.sciencedirect.com
    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    1. scibot 12 May 2021
      RRID:AB_2799008

      DOI: 10.1016/j.immuni.2021.04.019

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    sciencedirect.com/science/article/pii/S1074761321001813
  69. Apr 2021
  70. www.sciencedirect.com www.sciencedirect.com
    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    1. scibot 22 Apr 2021
      RRID:AB_2799008

      DOI: 10.1016/j.ccell.2020.11.004

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    sciencedirect.com/science/article/pii/S1535610820305961
  71. Feb 2021
  72. www.sciencedirect.com www.sciencedirect.com
    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    1. scibot 28 Feb 2021
      RRID:AB_2799008

      DOI: 10.1016/j.ccell.2020.11.006

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    sciencedirect.com/science/article/pii/S1535610820305985
  73. www.mdpi.com www.mdpi.com
    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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    1. scibot 27 Feb 2021
      RRID:AB_2799008

      DOI: 10.3390/antiox10020334

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    mdpi.com/2076-3921/10/2/334
  74. www.sciencedirect.com www.sciencedirect.com
    Disruption of DNA polymerase ζ engages an innate immune response
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    1. scibot 25 Feb 2021
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2021.108775

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    sciencedirect.com/science/article/pii/S2211124721000887
  75. Dec 2020
  76. www.sciencedirect.com www.sciencedirect.com
    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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    1. scibot 12 Dec 2020
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2020.108490

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    sciencedirect.com/science/article/pii/S2211124720314790
  77. Sep 2020
  78. www.sciencedirect.com www.sciencedirect.com
    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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    1. scibot 14 Sep 2020
      RRID:AB_2799008

      DOI: 10.1016/j.immuni.2020.01.014

      Resource: (Cell Signaling Technology Cat# 31659, RRID:AB_2799008)

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    sciencedirect.com/science/article/pii/S107476132030042X
  79. Jan 2020
  80. www.sciencedirect.com www.sciencedirect.com
    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    1. scibot 13 Jan 2020
      RRID:AB_2799008

      DOI: 10.1016/j.celrep.2019.09.065

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    sciencedirect.com/science/article/pii/S2211124719312628