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Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML

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1. scibot 30 Jan 2026
  
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  DOI: 10.1016/j.cmet.2026.01.001
  
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sciencedirect.com/science/article/pii/S155041312600001X
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Photo‐Empowered Macrophage‐Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery

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1. scibot 30 Jan 2026
  
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  DOI: 10.1002/advs.202515349
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12850126/
Jan 2026
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IRF3 attenuates hypoxia signaling by retaining HIF-α in the cytoplasm

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1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116815
  
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sciencedirect.com/science/article/pii/S2211124725015876
Dec 2025
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Mitochondrial VHL rewires cell metabolism in hypoxia

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.013
  
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sciencedirect.com:5037/science/article/pii/S1550413125005273
Sep 2025
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Neuropeptide adrenomedullin remodels stemness and macrophage dynamics in glioblastoma

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1. scibot 25 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116342
  
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sciencedirect.com/science/article/pii/S2211124725011131
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LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer

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1. scibot 16 Sep 2025
  
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  DOI: 10.1038/s41368-025-00396-2
  
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nature.com/articles/s41368-025-00396-2
Aug 2025
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BPS Publications

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1. scibot 14 Aug 2025
  
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  DOI: 10.1111/bph.70157
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70157
Jul 2025
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HIF-independent oxygen sensing via KDM6A regulates ferroptosis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.07.001
  
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sciencedirect.com/science/article/pii/S1097276525005805
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SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-3256
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
May 2025
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Heterogeneous Responses to High-Dose Testosterone in Castration-Resistant Prostate Cancer Tumors with Mixed Rb-Proficient and Rb-Deficient Cells

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1. scibot 20 May 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046331/
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Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115627
  
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sciencedirect.com/science/article/pii/S2211124725003985
Apr 2025
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  DOI: 10.1158/0008-5472.can-24-3481
  
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52.53.155.43/4e618aba3cd65bbf93907d966435a11f880c620c/PDF-html.html
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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.009
  
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sciencedirect.com/science/article/pii/S1097276525002023
Mar 2025
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ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102038
  
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sciencedirect.com/science/article/pii/S2666379125001119
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sPLA2-IB and PLA2R Mediate Aberrant Glucose Metabolism in Podocytes via Hyperactivation of the mTOR/HIF-1α Pathway

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1. scibot 14 Mar 2025
  
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  DOI: 10.1007/s12013-025-01714-5
  
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link.springer.com/article/10.1007/s12013-025-01714-5
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Hypoxia inducible factor-1α drives cancer resistance to cuproptosis

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1. scibot 07 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.015
  
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sciencedirect.com/science/article/pii/S1535610825000674
Feb 2025
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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/2159-8290.CD-21-1022
  
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aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
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Lactate controls cancer stemness and plasticity through epigenetic regulation

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.002
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00002-6
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Rhodoquinone carries electrons in the mammalian electron transport chain

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.cell.2024.12.007
  
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sciencedirect.com/science/article/pii/S009286742401420X
Jan 2025
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A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

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1. scibot 31 Jan 2025
  
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  DOI: 10.1101/2025.01.26.634856
  
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52.53.155.43/79f18ee8720d66564852d009166058cb2d19618c/PDF-html.html
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ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs

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1. scibot 25 Jan 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-2115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11250573/
Oct 2024
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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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1. scibot 02 Oct 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-01299
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11438333/
Sep 2024
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Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages

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1. scibot 26 Sep 2024
  
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The Effect of Hypoxia on Irisin Expression in HL-1 Cardiomyocytes

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1. scibot 05 Sep 2024
  
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  DOI: 10.21873/invivo.13675
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11363745/
Aug 2024
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Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome

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  DOI: 10.1016/j.cmet.2024.07.003
  
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sciencedirect.com/science/article/pii/S1550413124002742
Jun 2024
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HIF-1 induced tiRNA-Lys-CTT-003 is protective against cisplatin induced ferroptosis of renal tubular cells in mouse AKI model

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.bbadis.2024.167277
  
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sciencedirect.com/science/article/pii/S0925443924002667
May 2024
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Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.022
  
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sciencedirect.com/science/article/pii/S1074761324002279
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BPS Publications

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  DOI: 10.1111/bph.16358
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16358
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Cell-Membrane-Coated Metal–Organic Framework Nanocarrier Combining Chemodynamic Therapy for the Inhibition of Hepatocellular Carcinoma Proliferation

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1. scibot 09 May 2024
  
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  DOI: 10.3390/pharmaceutics16050619
  
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mdpi.com/1999-4923/16/5/619
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Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma

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1. scibot 07 May 2024
  
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sciencedirect.com/science/article/pii/S0928098724001003
Apr 2024
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Hypoxia exposure blunts angiogenic signaling and upregulates the antioxidant system in endothelial cells derived from elephant seals

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  DOI: 10.1186/s12915-024-01892-3
  
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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

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  DOI: 10.1016/j.celrep.2024.114094
  
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  DOI: 10.1016/j.celrep.2024.114094
  
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Oxygen–Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes

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1. scibot 03 Apr 2024
  
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  RRID:AB_2936488
  
  DOI: 10.3390/brainsci14030244
  
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mdpi.com/2076-3425/14/3/244
Mar 2024
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Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma

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1. scibot 22 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109340
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945209/
Jan 2024
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O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK

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1. scibot 20 Jan 2024
  
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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

1
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Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes

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SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1

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m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation

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Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection

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HIF-1α inhibition in macrophages preserves acute liver failure by reducing IL-1β production

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HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

2
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Jun 2023
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Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation

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UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders

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A tissue injury sensing and repair pathway distinct from host pathogen defense

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PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation

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Immunoediting instructs tumor metabolic reprogramming to support immune evasion

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Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence

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Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers

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Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1 β-Induced Endothelium Injury

1
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Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress

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The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity

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cd-21-1022-html.html

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Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway.

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Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

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Chromatin remodeling induced by ARID1A loss in lung cancer promotes glycolysis and confers JQ1 vulnerability

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Feb 2022
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Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation

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Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules

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GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

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GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

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PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory

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LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms

1
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May 2021
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Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

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Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

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  DOI: 10.1016/j.devcel.2020.07.014
  
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Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

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Feb 2021
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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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  DOI: 10.7554/eLife.61406
  
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Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

1
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  RRID:AB_279909
  
  DOI: 10.3389/fphys.2020.572911
  
  Resource: (Cell Signaling Technology Cat# 36169, RRID:AB_2799095)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2799095
  
  What is this?
  
  RRIDCUR:Incorrect RRIDCUR:Unresolved RRID:AB_2799095
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RRIDCUR:Incorrect

RRIDCUR:Unresolved

RRID:AB_2799095

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scibot

URL

frontiersin.org/article/10.3389/fphys.2020.572911/full
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation

1
1. scibot 24 Oct 2020
  
  in Public
  
  RRID:AB_2799095
  
  DOI: 10.7554/eLife.61762
  
  Resource: AB_2799095
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2799095
  
  What is this?
  
  RRIDCUR:Validated RRID:AB_2799095
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RRIDCUR:Validated

RRID:AB_2799095

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scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7550189/

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