Hypothesis

25 Matching Annotations

Last 7 days
www.sciencedirect.com www.sciencedirect.com

Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy

1
1. scibot 06 Nov 2025
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.xcrm.2025.102434
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2666379125005075
Oct 2025
www.sciencedirect.com www.sciencedirect.com

IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1

1
1. scibot 01 Oct 2025
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.celrep.2025.116336
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124725011076
Aug 2025
www.sciencedirect.com www.sciencedirect.com

Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

1
1. scibot 27 Aug 2025
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.devcel.2025.07.023
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S153458072500499X
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence

1
1. scibot 25 Jun 2025
  
  in Public
  
  AB_2799375
  
  DOI: 10.12688/f1000research.155929.2
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

pmc.ncbi.nlm.nih.gov/articles/PMC12175898/
May 2025
www.sciencedirect.com www.sciencedirect.com

MPXV infection activates cGAS-STING signaling and IFN-I treatment reduces pathogenicity of mpox in CAST/EiJ mice and rhesus macaques

1
1. scibot 22 May 2025
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.xcrm.2025.102135
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2666379125002083
Mar 2025
www.sciencedirect.com www.sciencedirect.com

Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

1
1. scibot 11 Mar 2025
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.ccell.2025.02.014
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610825000662
Dec 2024
www.sciencedirect.com www.sciencedirect.com

The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

1
1. scibot 17 Dec 2024
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.immuni.2024.11.017
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1074761324005326
www.sciencedirect.com www.sciencedirect.com

Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

1
1. scibot 10 Dec 2024
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.celrep.2024.115048
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124724013998
Oct 2024
www.sciencedirect.com www.sciencedirect.com

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

1
1. scibot 02 Oct 2024
  
  in Public
  
  AB_2799375
  
  DOI: 10.1016/j.neuron.2024.09.006
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S0896627324006548
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance

1
1. scibot 26 Jul 2024
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.isci.2024.110150
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC11261061/
Apr 2024
www.sciencedirect.com www.sciencedirect.com

Blocking cGAS-STING pathway promotes post-stroke functional recovery in an extended treatment window via facilitating remyelination

1
1. scibot 25 Apr 2024
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.medj.2024.03.018
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2666634024001302
www.sciencedirect.com www.sciencedirect.com

ISGylation by HERCs facilitates STING activation

1
1. scibot 23 Apr 2024
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.celrep.2024.114135
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124724004637
Jan 2024
www.sciencedirect.com www.sciencedirect.com

CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

1
1. scibot 07 Jan 2024
  
  in Public
  
  AB_2799375
  
  DOI: 10.1016/j.celrep.2023.113626
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124723016376
Nov 2023
www.sciencedirect.com www.sciencedirect.com

Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis

1
1. scibot 28 Nov 2023
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.immuni.2023.11.001
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/abs/pii/S1074761323004582
www.sciencedirect.com www.sciencedirect.com

Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

1
1. scibot 02 Nov 2023
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.immuni.2023.09.012
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/abs/pii/S107476132300417X
Apr 2023
www.sciencedirect.com www.sciencedirect.com

Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation

1
1. scibot 22 Apr 2023
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.isci.2023.106613
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2589004223006909
Dec 2022
www.sciencedirect.com www.sciencedirect.com

Cancer cell-derived type I interferons instruct tumor monocyte polarization

1
1. scibot 08 Dec 2022
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.celrep.2022.111769
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722016527
Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

1
1. scibot 30 Sep 2022
  
  in Public
  
  AB_2799375
  
  DOI: 10.1016/j.isci.2022.105145
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
www.sciencedirect.com www.sciencedirect.com

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

1
1. scibot 24 Sep 2022
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.ccell.2022.08.015
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610822003798
www.sciencedirect.com www.sciencedirect.com

Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase

1
1. scibot 08 Sep 2022
  
  in Public
  
  RRID:AB_2920553
  
  DOI: 10.1016/j.celrep.2022.111310
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @a5munoz
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375 RRIDCUR:Unresolved
Visit annotations in context

Tags

RRID:AB_2799375

RRIDCUR:Unresolved

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2211124722011342
Jun 2022
www.sciencedirect.com www.sciencedirect.com

The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity

1
1. scibot 22 Jun 2022
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.isci.2022.104561
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S2589004222008331
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

1
1. scibot 11 Dec 2021
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.isci.2021.103434
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375
Visit annotations in context

Tags

RRID:AB_2799375

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC8633968/
Jul 2021
www.nature.com www.nature.com

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

1
1. scibot 31 Jul 2021
  
  in Public
  
  50494
  
  DOI: 10.1038/s41586-021-03762-2
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375 RRIDCUR:Missing
Visit annotations in context

Tags

RRID:AB_2799375

RRIDCUR:Missing

Annotators

scibot

URL

nature.com/articles/s41586-021-03762-2
Apr 2021
www.sciencedirect.com www.sciencedirect.com

Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

1
1. scibot 17 Apr 2021
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.1016/j.ccell.2020.05.020
  
  Resource: (Cell Signaling Technology Cat# 50494, RRID:AB_2799375)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2799375

RRIDCUR:Validated

Annotators

scibot

URL

sciencedirect.com/science/article/pii/S1535610820302701
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reactive oxygen species oxidize STING and suppress interferon production

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:AB_2799375
  
  DOI: 10.7554/eLife.57837
  
  Resource: AB_2799375
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2799375
  
  What is this?
  
  RRID:AB_2799375 RRIDCUR:Validated
Visit annotations in context

Tags

RRID:AB_2799375

RRIDCUR:Validated

Annotators

scibot

URL

ncbi.nlm.nih.gov/pmc/articles/PMC7473769/