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Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress

1
1. scibot 03 Sep 2025
  
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  DOI: 10.1126/sciadv.ady0240
  
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science.org/doi/10.1126/sciadv.ady0240
Aug 2025
52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM-html.html

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1. scibot 15 Aug 2025
  
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  AB_2799632
  
  DOI: 10.1038/s41467-025-56346-3
  
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52.53.155.43/0cdd1395338fbad58a2c837457ae32b83153d0d5/41467_2025_56346_MOESM1_ESM-html.html
Jul 2025
52.53.155.43 52.53.155.43

41467_2025_56346_MOESM1_ESM (1)-html.html

1
1. scibot 19 Jul 2025
  
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  AB_2799632
  
  DOI: 10.1038/s41467-025-56346-3
  
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52.53.155.43/1761484a67730362675820c7685649e27bb2d182/41467_2025_56346_MOESM1_ESM (1)-html.html
Jun 2025
www.sciencedirect.com www.sciencedirect.com

Mitochondrial fumarate inhibits Parkin-mediated mitophagy

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.molcel.2025.05.021
  
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sciencedirect.com/science/article/pii/S1097276525004605
Apr 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 06 Apr 2025
  
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  RRID:AB_2799632
  
  DOI: 10.1101/2025.04.01.646648
  
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52.53.155.43/3ea6483f2803c23587cd02bb657f1ea0f411dd10/PDF-html.html
Aug 2024
www.sciencedirect.com www.sciencedirect.com

Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic

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1. scibot 27 Aug 2024
  
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  AB_2799632
  
  DOI: 10.1016/j.cub.2024.07.088
  
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sciencedirect.com/science/article/pii/S0960982224010273
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy

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1. scibot 25 May 2024
  
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  RRID:AB_2799632
  
  DOI: 10.1038/s41598-024-60602-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11111795/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bisbiguanide analogs induce mitochondrial stress to inhibit lung cancer cell invasion

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1. scibot 20 Apr 2024
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.isci.2024.109591
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11022046/
Feb 2024
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The HRI branch of the integrated stress response selectively triggers mitophagy

2
1. scibot 14 Feb 2024
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.molcel.2024.01.016
  
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2. scibot 14 Feb 2024
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.molcel.2024.01.016
  
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sciencedirect.com/science/article/pii/S1097276524000522
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Interaction of PINK1 with nucleotides and kinetin

1
1. scibot 23 Jan 2024
  
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  RRID:AB_2799632
  
  DOI: 10.1126/sciadv.adj7408
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10798554/
Sep 2023
www.sciencedirect.com www.sciencedirect.com

Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling

1
1. scibot 08 Sep 2023
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.molcel.2023.08.005
  
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sciencedirect.com/science/article/pii/S109727652300641X
Aug 2023
www.biorxiv.org www.biorxiv.org

KAT8 compound inhibition inhibits PINK1/Parkin-dependent mitophagy and initiates mitochondrial delivery to lysosomes

1
1. scibot 12 Aug 2023
  
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  RRID:AB_2799632
  
  DOI: 10.1101/2023.08.03.551835
  
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biorxiv.org/content/10.1101/2023.08.03.551835v1
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage

1
1. scibot 27 Jul 2023
  
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  RRID:AB_2799632
  
  DOI: 10.1371/journal.pgen.1010828
  
  Resource: (Cell Signaling Technology Cat# 62802, RRID:AB_2799632)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10368295/
Jan 2022
www.sciencedirect.com www.sciencedirect.com

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

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1. scibot 06 Jan 2022
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.isci.2021.103650
  
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sciencedirect.com/science/article/pii/S2589004221016205
Dec 2021
www.sciencedirect.com www.sciencedirect.com

Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex

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1. scibot 07 Dec 2021
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.molcel.2021.11.012
  
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sciencedirect.com/science/article/pii/S1097276521009916
Nov 2021
www.cell.com www.cell.com

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

1
1. scibot 10 Nov 2021
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.celrep.2021.109977
  
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cell.com/cell-reports/fulltext/S2211-1247(21)01456-X
Oct 2021
www.sciencedirect.com www.sciencedirect.com

Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

1
1. scibot 27 Oct 2021
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.celrep.2021.109888
  
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sciencedirect.com/science/article/pii/S2211124721013589
May 2021
www.sciencedirect.com www.sciencedirect.com

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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1. scibot 06 May 2021
  
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  RRID:AB_2799632
  
  DOI: 10.1016/j.devcel.2020.11.016
  
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sciencedirect.com/science/article/pii/S1534580720309254