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Dehydrocostus Lactone Effectively Alleviates Inflammatory Diseases by Covalently and Irreversibly Targeting NLRP3

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1. scibot 06 Sep 2025
  
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  DOI: 10.1002/mco2.70367
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12408923/
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Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer’s disease

1
1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.immuni.2025.07.024
  
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sciencedirect.com/science/article/pii/S1074761325003334
Jul 2025
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TREM2‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization

1
1. scibot 30 Jul 2025
  
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  DOI: 10.1096/fj.202501793R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12302306/
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Colchicine inhibits vascular calcification by suppressing inflammasome activation through the enhancement of the Sirt2-PP2Ac signaling pathway

1
1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.jbc.2025.110381
  
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sciencedirect.com/science/article/pii/S0021925825022318
Jun 2025
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Piezo1 senses hyphae and initiates host defense against pathogenic fungi

1
1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115839
  
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sciencedirect.com/science/article/pii/S2211124725006102
May 2025
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Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways

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1. scibot 21 May 2025
  
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  DOI: 10.1186/s12987-025-00658-5
  
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link.springer.com/article/10.1186/s12987-025-00658-5
Apr 2025
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Lysosome positioning affects NLRP3 inflammasome activation

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1. scibot 03 Apr 2025
  
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  DOI: 10.1101/2025.03.21.644552
  
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52.53.155.43/5e725b42faf6f4894ebfb1897ac6165b04d7cac3/PDF-html.html
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Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure

1
1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115479
  
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sciencedirect.com/science/article/pii/S2211124725002505
Dec 2024
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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control

1
1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.10.010
  
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sciencedirect.com/science/article/pii/S1074761324004904
Nov 2024
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Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation

1
1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111186
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11550584/
Jul 2024
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Inhibition of SIRT1 relieves hepatocarcinogenesis via alleviating autophagy and inflammation

1
1. scibot 30 Jul 2024
  
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  DOI: 10.1016/j.ijbiomac.2024.134120
  
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sciencedirect.com/science/article/pii/S0141813024049250
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NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization

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1. scibot 03 Jul 2024
  
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  DOI: 10.3389/fimmu.2024.1393819
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11199694/
Jun 2024
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Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization

1
1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.intimp.2024.112374
  
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sciencedirect.com/science/article/pii/S1567576924008944
May 2024
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Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

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1. scibot 01 May 2024
  
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  DOI: 10.1101/2024.04.19.590338
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11042255/
Apr 2024
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NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation

2
1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114070
  
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2. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114070
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11130711/
Mar 2024
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A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages

2
1. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113981
  
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2. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113981
  
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sciencedirect.com/science/article/pii/S2211124724003097
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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome

2
1. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113935
  
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2. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113935
  
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sciencedirect.com/science/article/pii/S2211124724002638
Feb 2024
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BPS Publications

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1. scibot 16 Feb 2024
  
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  DOI: 10.1111/bph.16283
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16283
Jan 2024
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Entrectinib inhibits NLRP3 inflammasome and inflammatory diseases by directly targeting NEK7

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1. scibot 12 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101310
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10772347/
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ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.cmet.2023.12.015
  
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sciencedirect.com/science/article/pii/S1550413123004655
Dec 2023
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ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation

2
1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.015
  
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2. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.015
  
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sciencedirect.com/science/article/pii/S1097276523009607
Nov 2023
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Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization

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1. scibot 10 Nov 2023
  
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  DOI: 10.1038/s41467-023-43180-8
  
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nature.com/articles/s41467-023-43180-8
Oct 2023
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Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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1. scibot 13 Oct 2023
  
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  RRID:AB_2799736
  
  DOI: 10.1016/j.isci.2023.108082
  
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cell.com/iscience/abstract/S2589-0042(23)02159-4
Jul 2023
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Bexarotene improves motor function after spinal cord injury in mice

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1. scibot 22 Jul 2023
  
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  RRID:AB_2799736
  
  DOI: 10.4103/1673-5374.373676
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10358692/
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Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.xcrm.2023.101129
  
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sciencedirect.com/science/article/pii/S2666379123002574
Jun 2023
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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice

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1. scibot 23 Jun 2023
  
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  DOI: 10.3390/antiox12061303
  
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mdpi.com/2076-3921/12/6/1303
May 2023
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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

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1. scibot 18 May 2023
  
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  DOI: 10.1016/j.isci.2023.106758
  
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sciencedirect.com/science/article/pii/S2589004223008350
Apr 2023
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The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome

1
1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.immuni.2023.03.003
  
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sciencedirect.com/science/article/pii/S1074761323001231
Mar 2023
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TUG-891 inhibits neuronal endoplasmic reticulum stress and... : Neural Regeneration Research

1
1. scibot 30 Mar 2023
  
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  RRID:AB_2799736
  
  DOI: 10.4103/1673-5374.369116
  
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journals.lww.com/nrronline/Fulltext/2023/10000/TUG_891_inhibits_neuronal_endoplasmic_reticulum.34.aspx
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Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

1
1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.immuni.2023.02.014
  
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sciencedirect.com/science/article/pii/S1074761323000882
Feb 2023
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Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation

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1. scibot 16 Feb 2023
  
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  DOI: 10.1016/j.immuni.2023.01.015
  
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sciencedirect.com/science/article/pii/S1074761323000250
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Transmission of NLRP3-IL-1β Signals in Cerebral Ischemia and Reperfusion Injury: from Microglia to Adjacent Neuron and Endothelial Cells via IL-1β/IL-1R1/TRAF6

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1. scibot 02 Feb 2023
  
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  RRID:AB_2799736
  
  DOI: 10.1007/s12035-023-03232-y
  
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link.springer.com/article/10.1007/s12035-023-03232-y
Nov 2022
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Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111681
  
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Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35

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  DOI: 10.3389/fimmu.2022.1019365
  
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Jun 2022
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Investigating the NLRP3 Inflammasome and its Regulator miR-223-3p in Multiple Sclerosis and Experimental Demyelination

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  DOI: 10.1111/jnc.15650
  
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Apr 2022
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Obstructive sleep apnea aggravates neuroinflammation and... : Neural Regeneration Research

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  DOI: 10.4103/1673-5374.339000
  
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Mar 2022
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Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury

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  DOI: 10.1186/s12974-022-02427-9
  
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miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice

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1. scibot 28 Jan 2022
  
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  DOI: 10.1007/s13105-022-00871-y
  
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Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis

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Dec 2021
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  DOI: 10.1111/bph.15702
  
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NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

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  DOI: 10.1016/j.cell.2021.11.011
  
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Oct 2021
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Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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May 2021
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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

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Nov 2020
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LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

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  DOI: 10.7554/eLife.59704
  
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Sep 2020
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  DOI: 10.1111/bph.14806
  
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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

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  DOI: 10.1111/bph.15182
  
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