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Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeted KRASG12V Degradation in vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis

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1. scibot 17 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-5172
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7619155/
Apr 2026
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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.molcel.2026.03.004
  
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sciencedirect.com/science/article/pii/S1097276526001607
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

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1. scibot 19 Dec 2025
  
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  DOI: 10.7554/eLife.106699
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12700530/
Aug 2025
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A method for the detection and enrichment of endogenous cereblon substrates

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1. scibot 09 Aug 2025
  
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  DOI: 10.1016/j.chembiol.2025.07.002
  
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sciencedirect.com/science/article/pii/S2451945625002259
Apr 2025
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CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.chembiol.2025.03.006
  
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sciencedirect.com/science/article/pii/S2451945625000960
52.53.155.43 52.53.155.43

Unbiased mapping of cereblon neosubstrate landscape by high-throughput proteomics

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1. scibot 11 Apr 2025
  
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  DOI: 10.1101/2024.10.18.618633
  
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52.53.155.43/92810c2c243b5a771dae79b4024a23daa60516f1/2024.10.18.618633.full-html.html
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)

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1. scibot 11 Dec 2024
  
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  DOI: 10.7554/eLife.98450
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11623929/
Nov 2024
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Degradome analysis to identify direct protein substrates of small-molecule degraders

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.chembiol.2024.10.007
  
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sciencedirect.com/science/article/pii/S2451945624004422
Oct 2024
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Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.chembiol.2024.09.004
  
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sciencedirect.com/science/article/pii/S2451945624003969
Sep 2024
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GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant

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1. scibot 04 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.006
  
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sciencedirect.com/science/article/pii/S1535610824003052
Jul 2023
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Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

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1. scibot 01 Jul 2023
  
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  DOI: 10.1016/j.chom.2023.05.030
  
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sciencedirect.com/science/article/pii/S1931312823002238
Nov 2022
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Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation

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1. scibot 03 Nov 2022
  
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  DOI: 10.1016/j.chembiol.2022.10.007
  
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sciencedirect.com/science/article/pii/S2451945622003610
Sep 2022
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Target protein localization and its impact on PROTAC-mediated degradation

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1. scibot 08 Sep 2022
  
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  DOI: 10.1016/j.chembiol.2022.08.004
  
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sciencedirect.com/science/article/pii/S2451945622003129
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Exploring the target scope of KEAP1 E3 ligase-based PROTACs

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1. scibot 08 Sep 2022
  
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  DOI: 10.1016/j.chembiol.2022.08.003
  
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sciencedirect.com/science/article/pii/S2451945622003117
Mar 2022
aacrjournals.org aacrjournals.org

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

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1. scibot 10 Mar 2022
  
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  DOI: 10.1158/2159-8290.CD-21-0385
  
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aacrjournals.org/cancerdiscovery/article/12/3/730/681918/EP300-Selectively-Controls-the-Enhancer-Landscape
Jan 2020
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Development and Characterization of a Wee1 Kinase Degrader

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1. scibot 13 Jan 2020
  
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  RRID:AB_2799810
  
  DOI: 10.1016/j.chembiol.2019.10.013
  
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  Curator: @ethanbadger
  
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  RRID:AB_2799810 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2451945619303587
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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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1. scibot 13 Jan 2020
  
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  RRID:AB_2799810
  
  DOI: 10.1016/j.ccell.2019.10.002
  
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  RRID:AB_2799810 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819304763