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Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation

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1. scibot 01 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.007
  
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sciencedirect.com/science/article/pii/S1074761325004613
Oct 2025
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116433
  
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sciencedirect.com/science/article/pii/S2211124725012045
Sep 2025
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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sciencedirect.com/science/article/pii/S2211124725010940
Jul 2025
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101106
  
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Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0289
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695182/
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102211
  
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sciencedirect.com/science/article/pii/S2666379125002848
May 2025
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MPXV infection activates cGAS-STING signaling and IFN-I treatment reduces pathogenicity of mpox in CAST/EiJ mice and rhesus macaques

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102135
  
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115733
  
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sciencedirect.com/science/article/pii/S2211124725005042
Apr 2025
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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115572
  
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sciencedirect.com/science/article/pii/S2211124725003432
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.005
  
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sciencedirect.com/science/article/pii/S1074761325001244
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.008
  
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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0834
  
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52.53.155.43/b8eb1cd1446295bdd52d11650093cdf439d34361/PDF-html.html
Mar 2025
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

1
1. scibot 11 Mar 2025
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2025.02.014
  
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sciencedirect.com/science/article/pii/S1535610825000662
Nov 2024
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
Sep 2024
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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
Jul 2024
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance

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1. scibot 26 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110150
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11261061/
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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sciencedirect.com/science/article/pii/S2666634024002484
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Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers

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1. scibot 12 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101648
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00362-8
Jun 2024
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.cell.2024.05.031
  
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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity

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1. scibot 08 Jun 2024
  
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  DOI: 10.1158/2326-6066.CIR-23-1078
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148535/
May 2024
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cir-23-1078-html.html

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1. scibot 23 May 2024
  
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  DOI: 10.1158/2326-6066.cir-23-1078
  
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52.53.155.43/ee0bd7762d373e957152429ed1d9032329c895e5/cir-23-1078-html.html
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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.redox.2024.103202
  
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Apr 2024
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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101528
  
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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

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1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.ccell.2024.04.004
  
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Mar 2024
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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

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1. scibot 01 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113870
  
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  DOI: 10.1016/j.celrep.2024.113870
  
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sciencedirect.com/science/article/pii/S2211124724001980
Jan 2024
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CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

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1. scibot 07 Jan 2024
  
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  DOI: 10.1016/j.celrep.2023.113626
  
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sciencedirect.com/science/article/pii/S2211124723016376
Nov 2023
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SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

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1. scibot 30 Nov 2023
  
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  DOI: 10.1158/2767-9764.CRC-23-0265
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
Aug 2023
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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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1. scibot 25 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113040
  
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Jul 2023
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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112852
  
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Jun 2023
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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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1. scibot 02 Jun 2023
  
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  DOI: 10.1016/j.ccell.2023.05.005
  
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sciencedirect.com/science/article/pii/S1535610823001733
Apr 2023
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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112442
  
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sciencedirect.com/science/article/pii/S2211124723004539
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Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation

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1. scibot 22 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106613
  
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sciencedirect.com/science/article/pii/S2589004223006909
Mar 2023
europepmc.org europepmc.org

Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING

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1. scibot 28 Mar 2023
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2023.112303
  
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europepmc.org/article/med/36952341
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The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus

1
1. scibot 28 Mar 2023
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2023.112306
  
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sciencedirect.com/science/article/pii/S2211124723003170
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NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

1
1. scibot 02 Mar 2023
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2023.112185
  
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sciencedirect.com/science/article/pii/S2211124723001961
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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

1
1. scibot 02 Mar 2023
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2023.112145
  
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sciencedirect.com/science/article/pii/S2211124723001560
Dec 2022
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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

1
1. scibot 24 Dec 2022
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2022.111868
  
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sciencedirect.com/science/article/pii/S2211124722017648
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Cancer cell-derived type I interferons instruct tumor monocyte polarization

1
1. scibot 08 Dec 2022
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2022.111769
  
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sciencedirect.com/science/article/pii/S2211124722016527
Sep 2022
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ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

1
1. scibot 07 Sep 2022
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.immuni.2022.08.006
  
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sciencedirect.com/science/article/pii/S1074761322003995
Jun 2022
rupress.org rupress.org

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

1
1. scibot 09 Jun 2022
  
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  RRID:AB_2799831
  
  DOI: 10.1083/jcb.202106046
  
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rupress.org/jcb/article/221/7/e202106046/213259/ER-lysosome-lipid-transfer-protein-VPS13C-PARK23
May 2022
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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

1
1. scibot 26 May 2022
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2022.110838
  
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sciencedirect.com/science/article/pii/S2211124722006118
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The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

1
1. scibot 11 May 2022
  
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  RRID:AB_279983
  
  DOI: 10.1016/j.immuni.2022.04.006
  
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sciencedirect.com/science/article/pii/S1074761322001777
Jan 2022
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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

1
1. scibot 05 Jan 2022
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.cmet.2021.12.007
  
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sciencedirect.com/science/article/pii/S1550413121006264
Jul 2021
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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

1
1. scibot 31 Jul 2021
  
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  72971
  
  DOI: 10.1038/s41586-021-03762-2
  
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nature.com/articles/s41586-021-03762-2
May 2021
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SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

1
1. scibot 08 May 2021
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.molcel.2020.12.024
  
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sciencedirect.com/science/article/pii/S109727652030945X
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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

1
1. scibot 08 May 2021
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.molcel.2020.10.021
  
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sciencedirect.com/science/article/pii/S1097276520307280
Apr 2021
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

1
1. scibot 22 Apr 2021
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2020.11.004
  
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sciencedirect.com/science/article/pii/S1535610820305961
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

1
1. scibot 17 Apr 2021
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2020.05.020
  
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sciencedirect.com/science/article/pii/S1535610820302701
Sep 2020
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2020.03.056
  
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sciencedirect.com/science/article/pii/S2211124720303703
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.immuni.2020.03.016
  
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  RRIDCUR:Validated RRID:AB_2799831
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sciencedirect.com/science/article/pii/S1074761320301291
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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

1
1. scibot 06 Sep 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.immuni.2020.02.002
  
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sciencedirect.com/science/article/pii/S107476132030073X
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C9orf72 in myeloid cells suppresses STING-induced inflammation

1
1. scibot 03 Sep 2020
  
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  phospo-STING Ser 365
  
  DOI: 10.1038/s41586-020-2625-x
  
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  Curator: @Naa003
  
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  Curator comments: Phospho-STING (Ser365) (D8F4W) Rabbit mAb antibody Cell Signaling Technology Cat# 72971
  
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nature.com/articles/s41586-020-2625-x
Jan 2020
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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2019.11.003
  
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sciencedirect.com/science/article/pii/S1535610819305239