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ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance

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1. scibot 24 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.118009
  
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Sep 2026
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Dendritic cell centric nanoengineering couples antigen acquisition and STING activation for cancer immunotherapy

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1. scibot 09 Sep 2026
  
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  DOI: 10.1016/j.xcrm.2026.103025
  
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Aug 2026
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MCT4-mediated lactate efflux promotes STING-dependent dendritic cell antitumor immunity

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1. scibot 03 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117778
  
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Jul 2026
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Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING

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1. scibot 20 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.023
  
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Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity

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1. scibot 14 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.010
  
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Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion

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1. scibot 03 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.004
  
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Jun 2026
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VEGFR2 inhibition potentiates STING-mediated antitumor immunity

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1. scibot 22 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117576
  
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Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages

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1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44319-026-00793-6
  
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Cytoplasmic relocation of nuclear Ku70 by Bruceine A augments cGAS–STING pathway-mediated anti-tumor immunity

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1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.apsb.2026.06.010
  
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Characterization of a transmembrane-activating STING agonist using genetically humanized mice

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  DOI: 10.1016/j.celrep.2026.117475
  
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May 2026
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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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1. scibot 09 May 2026
  
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  DOI: 10.1126/sciadv.aea6842
  
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Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.ccell.2026.03.023
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13215210/
Apr 2026
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advs74967-sup-0001-suppmat.docx-html.html

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1. scibot 11 Apr 2026
  
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  DOI: 10.1002/advs.202522764
  
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54.241.53.176/8f7474ccb0db38ef3abc02e1f9942a511c5917ed/advs74967-sup-0001-suppmat.docx-html.html
Mar 2026
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MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117059
  
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Feb 2026
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Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis

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1. scibot 12 Feb 2026
  
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  DOI: 10.1152/ajpheart.00589.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12889003/
Jan 2026
54.241.53.176 54.241.53.176

lucero-et-al-2026-cardiomyocyte--arrestins-mediate-inflammation-and-cgas-sting-activation-in-cvb3-viral-myocarditis-html.html

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1. scibot 10 Jan 2026
  
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  DOI: 10.6084/m9.figshare.30598013
  
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54.241.53.176/230152961d72a3d5781220ef3dcdb60ea10cf9d0/lucero-et-al-2026-cardiomyocyte--arrestins-mediate-inflammation-and-cgas-sting-activation-in-cvb3-viral-myocarditis-html.html
Dec 2025
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Activation of stimulator of interferon genes (STING) and inhibition of vascular endothelial growth factor receptor (VEGFR) by telatinib induce antitumor activity

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.jbc.2025.111038
  
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A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.immuni.2025.11.004
  
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Nov 2025
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Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116581
  
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An immunometabolic prodrug strategy overcomes DHODH inhibitor resistance in refractory melanoma

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1. scibot 18 Nov 2025
  
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  DOI: 10.1186/s13046-025-03566-6
  
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ID1 boosts antiviral immunity by countering PRMT5-mediated STING methylation

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  DOI: 10.1016/j.celrep.2025.116547
  
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Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation

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  DOI: 10.1016/j.immuni.2025.10.007
  
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Oct 2025
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116433
  
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Sep 2025
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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Jul 2025
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

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1. scibot 16 Jul 2025
  
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  DOI: 10.1016/j.crmeth.2025.101106
  
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Riluzole Enhancing anti-PD-1 Efficacy by Activating cGAS/STING Signaling in Colorectal Cancer

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0289
  
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102211
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281435/
May 2025
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MPXV infection activates cGAS-STING signaling and IFN-I treatment reduces pathogenicity of mpox in CAST/EiJ mice and rhesus macaques

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.xcrm.2025.102135
  
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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  DOI: 10.1016/j.celrep.2025.115733
  
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Apr 2025
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Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115572
  
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

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1. scibot 09 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.005
  
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.008
  
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PDF-html.html

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1. scibot 04 Apr 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0834
  
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52.53.155.43/b8eb1cd1446295bdd52d11650093cdf439d34361/PDF-html.html
Mar 2025
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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1. scibot 11 Mar 2025
  
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  DOI: 10.1016/j.ccell.2025.02.014
  
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sciencedirect.com/science/article/pii/S1535610825000662
Nov 2024
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Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy

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1. scibot 07 Nov 2024
  
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  DOI: 10.3389/fonc.2024.1441935
  
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Sep 2024
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IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

1
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  DOI: 10.1016/j.isci.2024.110693
  
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance

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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers

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Jun 2024
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity

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  DOI: 10.1158/2326-6066.CIR-23-1078
  
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May 2024
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cir-23-1078-html.html

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Development of nitroalkene-based inhibitors to target STING-dependent inflammation

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Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity

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Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

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CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise

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  DOI: 10.1016/j.celrep.2023.113626
  
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Nov 2023
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SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression

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  DOI: 10.1158/2767-9764.CRC-23-0265
  
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Aug 2023
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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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  DOI: 10.1016/j.celrep.2023.113040
  
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Jul 2023
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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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Jun 2023
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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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Apr 2023
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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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  DOI: 10.1016/j.celrep.2023.112442
  
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Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation

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Mar 2023
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Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING

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The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus

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  DOI: 10.1016/j.celrep.2023.112306
  
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NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking

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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

1
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  DOI: 10.1016/j.celrep.2023.112145
  
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Dec 2022
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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

1
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  DOI: 10.1016/j.celrep.2022.111868
  
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Cancer cell-derived type I interferons instruct tumor monocyte polarization

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Sep 2022
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ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

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Jun 2022
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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

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  DOI: 10.1083/jcb.202106046
  
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rupress.org/jcb/article/221/7/e202106046/213259/ER-lysosome-lipid-transfer-protein-VPS13C-PARK23
May 2022
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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

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The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

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  DOI: 10.1016/j.immuni.2022.04.006
  
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Jan 2022
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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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  DOI: 10.1016/j.cmet.2021.12.007
  
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Jul 2021
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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

1
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  DOI: 10.1038/s41586-021-03762-2
  
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nature.com/articles/s41586-021-03762-2
May 2021
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SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

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  DOI: 10.1016/j.molcel.2020.12.024
  
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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

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  DOI: 10.1016/j.molcel.2020.10.021
  
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sciencedirect.com/science/article/pii/S1097276520307280
Apr 2021
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

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1. scibot 22 Apr 2021
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2020.11.004
  
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

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1. scibot 17 Apr 2021
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2020.05.020
  
  Resource: (Cell Signaling Technology Cat# 72971, RRID:AB_2799831)
  
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sciencedirect.com/science/article/pii/S1535610820302701
Sep 2020
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

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1. scibot 23 Sep 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.celrep.2020.03.056
  
  Resource: (Cell Signaling Technology Cat# 72971, RRID:AB_2799831)
  
  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S2211124720303703
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

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1. scibot 16 Sep 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.immuni.2020.03.016
  
  Resource: (Cell Signaling Technology Cat# 72971, RRID:AB_2799831)
  
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  RRIDCUR:Validated RRID:AB_2799831
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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

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1. scibot 06 Sep 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.immuni.2020.02.002
  
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  RRIDCUR:Validated RRID:AB_2799831
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C9orf72 in myeloid cells suppresses STING-induced inflammation

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1. scibot 03 Sep 2020
  
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  phospo-STING Ser 365
  
  DOI: 10.1038/s41586-020-2625-x
  
  Resource: (Cell Signaling Technology Cat# 72971, RRID:AB_2799831)
  
  Curator: @Naa003
  
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  Curator comments: Phospho-STING (Ser365) (D8F4W) Rabbit mAb antibody Cell Signaling Technology Cat# 72971
  
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nature.com/articles/s41586-020-2625-x
Jan 2020
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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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1. scibot 13 Jan 2020
  
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  RRID:AB_2799831
  
  DOI: 10.1016/j.ccell.2019.11.003
  
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  RRID:AB_2799831 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819305239

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