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Targeting the tumor microenvironment: reprogramming macrophages as a novel therapeutic strategy in FUOM-deficient glioblastoma

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1. scibot 22 May 2026
  
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  DOI: 10.1038/s41419-026-08701-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13187179/
Apr 2026
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Vesicle trafficking 1 in breast cancer tissue and serum orchestrates metastatic progression and an immunosuppressive microenvironment

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  DOI: 10.1016/j.intimp.2026.116564
  
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sciencedirect.com/science/article/pii/S1567576926004091
Mar 2026
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Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma

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  DOI: 10.1016/j.xcrm.2026.102708
  
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Feb 2026
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TNF-⍺-mediated myeloid-instructed CD14+CD4+ T cells are associated with poor survival in lung adenocarcinoma

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A pan-cancer single-cell transcriptomic atlas of human bone metastases

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  DOI: 10.1016/j.xcrm.2025.102583
  
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sciencedirect.com/science/article/pii/S2666379125006561
Jan 2026
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An organ-conformal, kirigami-structured bioelectronic patch for precise intracellular delivery

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1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.021
  
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sciencedirect.com/science/article/pii/S0092867425014345
Dec 2025
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Long-term Survival and Molecular Biomarker Evaluation of a Phase II Cetuximab and Nivolumab Clinical Trial in Recurrent/Metastatic Head and Neck Cancer

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1. scibot 03 Dec 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12667737/
Oct 2025
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Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.stem.2025.09.011
  
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sciencedirect.com/science/article/pii/S1934590925003674
Sep 2025
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A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.devcel.2025.08.010
  
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SARC028 Samples Reveal an Interplay between TGF-β, IFN Signaling, and Low HLA Class I Expression as Contributors to Ewing Sarcoma Checkpoint Blockade Resistance

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1. scibot 07 Sep 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12402801/
Aug 2025
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SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

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1. scibot 19 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-1970
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12355175/
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The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.010
  
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sciencedirect.com/science/article/pii/S1534580725004484
Jul 2025
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A Novel B7-H4xCD3 Bispecific T-cell Engager (PF-07260437) Synergizes with Breast Cancer Standard of Care and Immune Checkpoint Therapies

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1. scibot 04 Jul 2025
  
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  DOI: 10.1158/1535-7163.MCT-24-0379
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214883/
Jun 2025
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1. scibot 13 Jun 2025
  
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  DOI: 10.1158/2159-8290.cd-24-1033
  
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52.53.155.43/a7ee3b12d468dfb2dd9f5d25a6280eb2adf38466/PDF-html.html
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BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102183
  
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
May 2025
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De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.cell.2025.05.003
  
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sciencedirect.com/science/article/pii/S0092867425005148
Apr 2025
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SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistance

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1. scibot 02 Apr 2025
  
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  DOI: 10.1101/2025.03.26.645492
  
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biorxiv.org/content/10.1101/2025.03.26.645492v1
Mar 2025
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1. scibot 26 Mar 2025
  
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  DOI: 10.1158/1078-0432.ccr-24-2830
  
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52.53.155.43/a10b0bb75a2bac4a87b48920938f3a8f4e03356b/PDF-html.html
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LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis

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Jan 2025
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Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial

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  DOI: 10.1016/j.xcrm.2025.101930
  
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sciencedirect.com/science/article/pii/S2666379125000035
Sep 2024
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Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification

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  DOI: 10.1038/s44318-024-00103-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11377571/
Aug 2024
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CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis

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1. scibot 21 Aug 2024
  
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Mar 2024
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A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

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  DOI: 10.1016/j.xcrm.2024.101399
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10897549/
Oct 2023
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Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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1. scibot 17 Oct 2023
  
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  DOI: 10.1126/sciadv.abo3610
  
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science.org/doi/10.1126/sciadv.abo3610
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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma

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1. scibot 13 Oct 2023
  
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sciencedirect.com/science/article/pii/S1535610823003276
Sep 2023
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Laeverin/aminopeptidase Q induces indoleamine 2,3-dioxygenase-1 in human monocytes

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1. scibot 17 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107692
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10495628/
Jun 2023
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Spatially resolved multi-omics single-cell analyses inform mechanisms of immune-dysfunction in pancreatic cancer

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  DOI: 10.1053/j.gastro.2023.05.036
  
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52.53.155.43/71ccfaec92c7763faf07cdf10a5de07b1aba97a1/1-s2.0-S0016508523008107-main-html.html
May 2023
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Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma

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  DOI: 10.1016/j.xcrm.2023.101044
  
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Jan 2023
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Cabozantinib plus durvalumab in advanced gastroesophageal cancer and other gastrointestinal malignancies: Phase Ib CAMILLA trial results

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  DOI: 10.1016/j.xcrm.2023.100916
  
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An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

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  DOI: 10.1016/j.chom.2022.12.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9731922/
Nov 2022
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Ewing sarcoma and osteosarcoma have distinct immune signatures and intercellular communication networks

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1. scibot 22 Nov 2022
  
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  DOI: 10.1158/1078-0432.CCR-22-1471
  
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aacrjournals.org/clincancerres/article/28/22/4968/710457/Ewing-Sarcoma-and-Osteosarcoma-Have-Distinct
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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

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1. scibot 18 Nov 2022
  
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  DOI: 10.1016/j.ccell.2022.10.021
  
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sciencedirect.com/science/article/pii/S1535610822005128
Oct 2022
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Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression

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1. scibot 11 Oct 2022
  
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  DOI: 10.1186/s12967-022-03661-8
  
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scibot

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link.springer.com/article/10.1186/s12967-022-03661-8
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

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1. scibot 13 Aug 2022
  
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  AB_2799882
  
  DOI: 10.1126/sciadv.abo3610
  
  Resource: (Cell Signaling Technology Cat# 76437, RRID:AB_2799882)
  
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  RRID:AB_2799882
2. scibot 13 Aug 2022
  
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  AB_2799882
  
  DOI: 10.1126/sciadv.abo3610
  
  Resource: (Cell Signaling Technology Cat# 76437, RRID:AB_2799882)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9299535/
Mar 2022
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Decoding the temporal and regional specification of microglia in the developing human brain

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1. scibot 04 Mar 2022
  
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  RRID:AB_2799882
  
  DOI: 10.1016/j.stem.2022.02.004
  
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sciencedirect.com/science/article/pii/S1934590922000558
Oct 2021
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Multiplexed imaging reveals an IFN-γ-driven inflammatory state in nivolumab-associated gastritis

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1. scibot 20 Oct 2021
  
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  RRID:AB_2799882
  
  DOI: 10.1016/j.xcrm.2021.100419
  
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sciencedirect.com/science/article/pii/S2666379121002810
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Atlas of clinically distinct cell states and ecosystems across human solid tumors

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1. scibot 01 Oct 2021
  
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  RRID:AB_2799882
  
  DOI: 10.1016/j.cell.2021.09.014
  
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sciencedirect.com/science/article/pii/S0092867421010618
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2799882
  
  DOI: 10.1016/j.immuni.2019.11.014
  
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  Curator: @ethanbadger
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7201194/