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Chromatin accessibility trajectories reveal pre-cancerous epigenetic priming and an acid-driven immunotherapy-resistant gastric cancer subtype

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  DOI: 10.1016/j.ccell.2026.09.004
  
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Jul 2026
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USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Co-evolution in Pancreatic Cancer

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  DOI: 10.1158/0008-5472.CAN-25-1228
  
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aacrjournals.org/cancerres/article/86/3/712/771921/USP20-Driven-Cholesterol-Metabolism-Links
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A Circulating GPNMB-Based Multimodal Model Integrates Tumor-Immune Crosstalk to Predict Immunotherapy Response in Esophageal Cancer

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Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion

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May 2026
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Spatially Resolved Obesity-Driven Molecular Changes in Early Breast Cancer

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sciencedirect.com/science/article/pii/S0002944026001240
Apr 2026
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cd-25-1907-html.html

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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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1. scibot 23 Apr 2026
  
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Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinoma

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Vesicle trafficking 1 in breast cancer tissue and serum orchestrates metastatic progression and an immunosuppressive microenvironment

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Mar 2026
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Unleashing T cell surveillance for the eradication of quiescent persister tumor cells resistant to neoadjuvant chemotherapy

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Immunological effects of amivantamab in EGFR or MET-expressing non-small cell lung cancer

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1. scibot 27 Mar 2026
  
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  DOI: 10.1007/s00262-026-04369-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13013883/
Jan 2026
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Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells

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1. scibot 30 Jan 2026
  
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  DOI: 10.1038/s41419-025-08362-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
Nov 2025
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Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102473
  
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Aug 2025
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USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment

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  DOI: 10.1158/2326-6066.CIR-24-1194
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314529/
Jul 2025
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Inhibition of KAT6A Enhances Immunotherapy Efficacy in Colorectal Cancer by Activating Interferon Response

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.canlet.2025.217946
  
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sciencedirect.com/science/article/pii/S0304383525005154
Jun 2025
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Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment

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1. scibot 12 Jun 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130809/
May 2025
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Spatial analysis identifies DC niches as predictors of pembrolizumab therapy in head and neck squamous cell cancer

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1. scibot 19 May 2025
  
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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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1. scibot 17 May 2025
  
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Spatial and multiomics analysis of human and mouse lung adenocarcinoma precursors reveals TIM-3 as a putative target for precancer interception

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sciencedirect.com/science/article/pii/S153561082500162X
Mar 2025
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AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity

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  DOI: 10.1016/j.celrep.2025.115445
  
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Feb 2025
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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
Jan 2025
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Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial

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Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma

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Dec 2024
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Interpretable multi-modal artificial intelligence model for predicting gastric cancer response to neoadjuvant chemotherapy

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Sep 2024
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Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics

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Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation

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Apr 2024
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells

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  DOI: 10.1016/j.cell.2024.03.011
  
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Mar 2024
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A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer

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  DOI: 10.1016/j.xcrm.2024.101399
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10897549/
Feb 2024
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can-23-0902-html.html

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52.53.155.43/bc36aa41a35e685a5842a671f3a3fbfdf01edb6a/276 (1)-html.html
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Genomic characteristics and immune landscape of super multiple primary lung cancer

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  DOI: 10.1016/j.ebiom.2024.105019
  
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Epigenetic dysregulation in Alzheimer’s disease peripheral immunity

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  DOI: 10.1016/j.neuron.2024.01.013
  
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sciencedirect.com/science/article/pii/S0896627324000394
Jan 2024
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Spatial and Single-Cell Transcriptomics Reveal a Cancer-Associated Fibroblast Subset in HNSCC That Restricts Infiltration and Antitumor Activity of CD8+ T Cells

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1. scibot 20 Jan 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-1448
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10790129/
Dec 2023
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Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma

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  RRID:AB_2800052
  
  DOI: 10.1016/j.ccell.2023.11.010
  
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52.53.155.43 52.53.155.43

can-23-0902-html.html

1
1. scibot 01 Dec 2023
  
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  AB_2800052
  
  DOI: 10.1158/0008-5472.can-23-0902
  
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52.53.155.43/bc36aa41a35e685a5842a671f3a3fbfdf01edb6a/276 (1)-html.html
Nov 2023
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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression

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1. scibot 17 Nov 2023
  
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  RRID:AB_2800052
  
  DOI: 10.1016/j.devcel.2023.10.010
  
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Sep 2023
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A cancer-associated fibroblast subtypes-based signature enables the evaluation of immunotherapy response and prognosis in bladder cancer

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  DOI: 10.1016/j.isci.2023.107722
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10485638/
Mar 2023
europepmc.org europepmc.org

Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity

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  DOI: 10.1016/j.celrep.2023.112275
  
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Jun 2022
52.53.155.43 52.53.155.43

cd-21-1022-html.html

3
1. scibot 30 Jun 2022
  
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  RRID:AB_2800052
  
  DOI: 10.1158/2159-8290.CD-21-1022
  
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2. scibot 25 Jun 2022
  
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  DOI: 10.1158/2159-8290.cd-21-1022
  
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3. scibot 25 Jun 2022
  
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  DOI: 10.1158/2159-8290.cd-21-1022
  
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52.53.155.43/dae3a722cb0f412060233d3b16799226aa47507e/cd-21-1022-html.html
Apr 2022
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Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas

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  DOI: 10.3389/fimmu.2022.824586
  
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May 2021
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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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  RRID:AB_2800052
  
  DOI: 10.1016/j.stem.2020.06.022
  
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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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  RRID:AB_2800052
  
  DOI: 10.1016/j.molcel.2021.02.038
  
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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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  RRID:AB_2800052
  
  DOI: 10.1016/j.stem.2021.04.011
  
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Sep 2020
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Transferrin Receptor Is a Specific Ferroptosis Marker

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  RRID:AB_2800052
  
  DOI: 10.1016/j.celrep.2020.02.049
  
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