21 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13066370/
  3. Nov 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    End-product inhibition of the LRRK2-counteracting PPM1H phosphatase
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132568/
  5. Sep 2025
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity and toxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11578116/
  7. www.sciencedirect.com www.sciencedirect.com
    Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0021925825025311
  8. Jul 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease
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    pmc.ncbi.nlm.nih.gov/articles/PMC12462683/
  10. Mar 2025
  11. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/c83c3399f0f3ceedbbadf4465eff5f081b0ef0bc/PDF-html.html
  12. Feb 2025
  13. 52.53.155.43 52.53.155.43
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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    52.53.155.43/01dd9728947fbe4affbd9309aaacf50825c24057/2024.10.14.618089.full-html.html
  14. May 2024
  15. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
    1
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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  16. Feb 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10835446/
  18. Dec 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  20. Oct 2023
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561555/
  22. May 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S221112472300459X
  24. Dec 2022
  25. www.nature.com www.nature.com
    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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    nature.com/articles/s41594-022-00863-y
  26. Nov 2022
  27. www.nature.com www.nature.com
    R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
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    nature.com/articles/s42003-022-04136-8
  28. Oct 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9555798/
  30. elifesciences.org elifesciences.org
    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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    elifesciences.org/articles/79771
  31. Sep 2022
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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    ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
  33. Jul 2022
  34. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
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    nature.com/articles/s41531-022-00354-3
  35. Jun 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    sciencedirect.com/science/article/pii/S2589004222007477
  37. Mar 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S0960982221003055
  39. Feb 2021
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC7609054/