18 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson’s disease
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    sciencedirect.com/science/article/pii/S0021925825025311
  3. Jul 2025
  4. www.sciencedirect.com www.sciencedirect.com
    PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease
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    sciencedirect.com/science/article/pii/S2211124725008022
  5. Mar 2025
  6. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/c83c3399f0f3ceedbbadf4465eff5f081b0ef0bc/PDF-html.html
  7. Feb 2025
  8. 52.53.155.43 52.53.155.43
    Knockout of the LRRK2-counteracting RAB phosphatase PPM1H disrupts axonal autophagy and exacerbates alpha-synuclein aggregation
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    52.53.155.43/01dd9728947fbe4affbd9309aaacf50825c24057/2024.10.14.618089.full-html.html
  9. May 2024
  10. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  11. Feb 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal stress drives the release of pathogenic α-synuclein from macrophage lineage cells via the LRRK2-Rab10 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10835446/
  13. Dec 2023
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  15. Oct 2023
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561555/
  17. May 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S221112472300459X
  19. Dec 2022
  20. www.nature.com www.nature.com
    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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    nature.com/articles/s41594-022-00863-y
  21. Nov 2022
  22. www.nature.com www.nature.com
    R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations
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    nature.com/articles/s42003-022-04136-8
  23. Oct 2022
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
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    ncbi.nlm.nih.gov/pmc/articles/PMC9555798/
  25. elifesciences.org elifesciences.org
    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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    elifesciences.org/articles/79771
  26. Sep 2022
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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    ncbi.nlm.nih.gov/pmc/articles/PMC9472821/
  28. Jul 2022
  29. www.nature.com www.nature.com
    LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
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    nature.com/articles/s41531-022-00354-3
  30. Jun 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement
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    sciencedirect.com/science/article/pii/S2589004222007477
  32. Mar 2021
  33. www.sciencedirect.com www.sciencedirect.com
    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    sciencedirect.com/science/article/pii/S0960982221003055
  34. Feb 2021
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC7609054/