Hypothesis

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A skin-hypothalamus axis couples heat stress and metabolic dysfunction

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.cell.2026.03.045
  
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sciencedirect.com/science/article/pii/S0092867426003466
Mar 2026
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Astrocytic AEBP1-NPAS3-LIPA pathway coordinates cholesterol homeostasis to regulate Alzheimer’s pathology

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117193
  
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sciencedirect.com/science/article/pii/S2211124726002718
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Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.neuron.2026.01.032
  
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sciencedirect.com/science/article/pii/S0896627326000577
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A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorder

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1. scibot 03 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102641
  
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sciencedirect.com/science/article/pii/S2666379126000583
Jan 2026
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CLN3 mediates chloride efflux from lysosomes

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.neuron.2025.11.013
  
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sciencedirect.com/science/article/pii/S0896627325008864
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Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.immuni.2025.11.022
  
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sciencedirect.com/science/article/pii/S1074761325005242
Dec 2025
54.241.53.176 54.241.53.176

s12974-025-03648-4_reference-html.html

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1. scibot 16 Dec 2025
  
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  DOI: 10.1186/s12974-025-03648-4
  
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54.241.53.176/a44cc0e7569e6d3c1fa351bb4696d083040f2f89/s12974-025-03648-4_reference-html.html
Nov 2025
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C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in acute brain injury

1
1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.neuron.2025.10.022
  
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sciencedirect.com/science/article/pii/S0896627325008037
Oct 2025
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Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility

1
1. scibot 14 Oct 2025
  
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  DOI: 10.7554/eLife.106814
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12490860/
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Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization

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1. scibot 11 Oct 2025
  
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  DOI: 10.1371/journal.ppat.1013563
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12510645/
Sep 2025
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A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy

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1. scibot 13 Sep 2025
  
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  DOI: 10.1016/j.neuron.2025.08.018
  
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sciencedirect.com/science/article/pii/S0896627325006245
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Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1

1
1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116266
  
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sciencedirect.com/science/article/pii/S221112472501037X
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2025.08.28.672784v1.full-html.html

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1. scibot 06 Sep 2025
  
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  DOI: 10.1101/2025.08.28.672784
  
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52.53.155.43/ac7f1767c23c6666ccfc705d09859fa9a6162a49/2025.08.28.672784v1.full-html.html
Aug 2025
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116130
  
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sciencedirect.com/science/article/pii/S2211124725009015
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Protocol for developing a mouse model of post-primary pulmonary tuberculosis after hematogenous spread in native lungs and lung implants

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1. scibot 02 Aug 2025
  
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  DOI: 10.1016/j.xpro.2025.103984
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12311599/
Jul 2025
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Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation

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1. scibot 30 Jul 2025
  
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  DOI: 10.4103/NRR.NRR-D-24-00394
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12296469/
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The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model

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1. scibot 17 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116012
  
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sciencedirect.com/science/article/pii/S2211124725007831
May 2025
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Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways

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1. scibot 21 May 2025
  
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  DOI: 10.1186/s12987-025-00658-5
  
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link.springer.com/article/10.1186/s12987-025-00658-5
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Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.028
  
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sciencedirect.com/science/article/pii/S1074761325001918
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Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115712
  
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sciencedirect.com/science/article/pii/S2211124725004838
Apr 2025
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Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease

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1. scibot 17 Apr 2025
  
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  DOI: 10.1523/JNEUROSCI.0967-24.2025
  
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jneurosci.org/content/45/10/e0967242025
Mar 2025
translational-medicine.biomedcentral.com translational-medicine.biomedcentral.com

Single-cell analysis identifies MKI67+ microglia as drivers of neovascularization in proliferative diabetic retinopathy

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1. scibot 13 Mar 2025
  
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  DOI: 10.1186/s12967-025-06320-w
  
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translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06320-w
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Mouse Adrenal Macrophages Are Associated with Pre- and Postsynaptic Neuronal Elements and Respond to Multiple Neuromodulators

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1. scibot 01 Mar 2025
  
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  DOI: 10.1523/ENEURO.0153-24.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11856350/
Feb 2025
academic.oup.com academic.oup.com

Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease

14
1. scibot 07 Feb 2025
  
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  RRID: AB_2820254
  
  DOI: 10.1093/hmg/ddae113
  
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2. scibot 07 Feb 2025
  
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  RRID: AB_2820254
  
  DOI: 10.1093/hmg/ddae113
  
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3. scibot 06 Feb 2025
  
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  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
4. scibot 06 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
5. scibot 05 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
6. scibot 05 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
7. scibot 04 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
8. scibot 04 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
9. scibot 03 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
10. scibot 03 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
11. scibot 02 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
12. scibot 02 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
13. scibot 01 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
14. scibot 01 Feb 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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academic.oup.com/hmg/article-abstract/33/20/1771/7727363
Jan 2025
academic.oup.com academic.oup.com

Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease

2
1. scibot 31 Jan 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2820254
2. scibot 31 Jan 2025
  
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  RRID: AB_2820254
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
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academic.oup.com/hmg/article-abstract/33/20/1771/7727363
52.53.155.43 52.53.155.43

1-s2.0-S2589004225000112-main-html.html

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1. scibot 07 Jan 2025
  
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  RRID:AB_2820254
  
  DOI: 10.1016/j.isci.2025.111752
  
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52.53.155.43/f3927b613620da7ae9927001d3d9d5a924748cb9/1-s2.0-S2589004225000112-main-html.html
Nov 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils

1
1. scibot 07 Nov 2024
  
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  RRID:AB_2820254
  
  DOI: 10.4103/1673-5374.385843
  
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Jul 2024
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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

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Jun 2024
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Direct comparison of Hoxb8-driven reporter distribution in the brains of four transgenic mouse lines: towards a spinofugal projection atlas

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May 2024
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Photoacoustic Tomography with Temporal Encoding Reconstruction (PATTERN) for cross-modal individual analysis of the whole brain

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Apr 2024
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Asparagine endopeptidase deficiency mitigates radiation-induced brain injury by suppressing microglia-mediated neuronal senescence

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Mar 2024
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Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway

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Dec 2023
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β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling Pathway

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Oct 2023
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mNSCs overexpressing Rimkla transplantation facilitates cognitive recovery in a mouse model of traumatic brain injury

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Sep 2023
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Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice

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Aug 2023
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JNEUROSCI.2124-22.2023.full-html.html

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Jul 2023
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Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

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Apr 2023
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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Mar 2023
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(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission

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Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

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Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection

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Traumatic axonal injury in the optic nerve: the selective role of SARM1 in the evolution of distal axonopathy

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Feb 2023
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A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages

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The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia

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Nov 2022
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Inhibition of indoleamine 2, 3-dioxygenase in prelimbic or infralimbic cortex of ICV-STZ rats can exert antidepressant effects through different pathways

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Oct 2022
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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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Jul 2022
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Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal rats

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The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity

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Apr 2022
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Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas

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Aug 2021
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Spinal Nrf2 translocation may inhibit neuronal NF-κB activation and alleviate allodynia in a rat model of bone cancer pain

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