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Mitochondrial Fis1 tunes Rab7A activity via TBC1D15 modulating STING degradation

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1. scibot 11 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.117994
  
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sciencedirect.com/science/article/pii/S2211124726010727
Aug 2026
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SADS-CoV nucleocapsid protein antagonizes DAD1-mediated STING activation to prevent cytosolic DNA sensing

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1. scibot 29 Aug 2026
  
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  DOI: 10.1016/j.celrep.2026.117917
  
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sciencedirect.com/science/article/pii/S2211124726009952
Jul 2026
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TNIK overexpression is sufficient for chemoradiation resistance in limited-stage small cell lung cancer

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1. scibot 12 Jul 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-0529
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13339944/
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Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion

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1. scibot 03 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.004
  
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sciencedirect.com/science/article/pii/S1074761326002554
Jun 2026
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DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer

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1. scibot 17 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3849
  
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aacrjournals.org/cancerres/article/86/12/2837/785625/DPY30-Is-an-Epigenetic-Decoupler-Linking
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STING-OPTN signaling confers cytoprotection through TBK1-dependent mitophagy

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1. scibot 11 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117515
  
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SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma

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1. scibot 10 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3195
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
May 2026
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STING signaling in vestibular macrophages underlies Ménière’s disease pathogenesis

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1. scibot 27 May 2026
  
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  DOI: 10.1186/s12974-026-03812-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13200447/
www.biorxiv.org www.biorxiv.org

It’s Not Rewarding for Mitochondria: Dopamine-Induced Mitochondrial Dysfunction Activates cGAS-STING to Drive IL-6 Secretion in Macrophages

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1. scibot 01 May 2026
  
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  DOI: 10.64898/2026.04.23.719926
  
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biorxiv.org/content/10.64898/2026.04.23.719926v1
Apr 2026
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Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma

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1. scibot 16 Apr 2026
  
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  DOI: 10.1016/j.xcrm.2026.102748
  
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1-s2.0-S2589004226010862-main-html.html

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1. scibot 11 Apr 2026
  
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  DOI: 10.1016/j.isci.2026.115711
  
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54.241.53.176/be028d43344bab6907bc9e771fd88e2dec1a0cd7/1-s2.0-S2589004226010862-main-html.html
Mar 2026
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STING signaling modulation by COPII cargo recognition

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.cell.2026.02.029
  
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sciencedirect.com/science/article/pii/S0092867426002679
Nov 2025
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Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer

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1. scibot 24 Nov 2025
  
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  DOI: 10.1038/s41598-025-23137-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
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Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy

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1. scibot 06 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102434
  
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sciencedirect.com/science/article/pii/S2666379125005075
Oct 2025
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116433
  
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sciencedirect.com/science/article/pii/S2211124725012045
Sep 2025
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Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization

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1. scibot 27 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116350
  
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sciencedirect.com/science/article/pii/S2211124725011210
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RSK1 reprograms the ubiquitin pathway to promote immune suppression

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116323
  
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sciencedirect.com/science/article/pii/S2211124725010940
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ZBP1 pathway promotes tumor immunogenicity in the combination of anti-HER2 therapy and epigenetic therapy

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1. scibot 17 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116314
  
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sciencedirect.com/science/article/pii/S221112472501085X
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
Jun 2025
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Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.xcrm.2025.102198
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12281382/
Apr 2025
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1097276525002011
Feb 2025
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.cell.2025.01.027
  
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sciencedirect.com/science/article/pii/S0092867425000960
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IKKɛ induces STING non-IFN immune responses via a mechanism analogous to TBK1

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1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11387596/
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A TBK1-independent primordial function of STING in lysosomal biogenesis

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
Jul 2024
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
May 2024
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Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING

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1. scibot 21 May 2024
  
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  DOI: 10.1016/j.molcel.2024.04.017
  
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sciencedirect.com/science/article/pii/S109727652400354X
Mar 2024
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A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress-Induced Inflammation

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1. scibot 17 Mar 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-1237
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10940857/
Feb 2024
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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113792
  
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sciencedirect.com/science/article/pii/S2211124724001207
Nov 2023
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113352
  
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sciencedirect.com/science/article/pii/S2211124723013645
Sep 2023
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STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

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1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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sciencedirect.com/science/article/pii/S2211124723011191
Jul 2023
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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112852
  
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sciencedirect.com/science/article/pii/S221112472300863X
Jun 2023
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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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1. scibot 02 Jun 2023
  
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  DOI: 10.1016/j.ccell.2023.05.005
  
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sciencedirect.com/science/article/pii/S1535610823001733
Apr 2023
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The mechanism of STING autoinhibition and activation

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1. scibot 22 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.03.029
  
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sciencedirect.com/science/article/pii/S1097276523002435
Mar 2023
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Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112179
  
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sciencedirect.com/science/article/pii/S2211124723001900
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ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation

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1. scibot 22 Mar 2023
  
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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

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The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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