Hypothesis

60 Matching Annotations

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Heat shock protein 90β lactylation acts as a metabolic switch to drive cerebrovascular apoptosis under heat stress

1
1. scibot 29 Apr 2026
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.celrep.2026.117317
  
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sciencedirect.com/science/article/pii/S2211124726003955
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

1
1. scibot 24 Apr 2026
  
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  RRID:AB_2868521
  
  DOI: 10.1002/advs.202509148
  
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  Curator: @nmaralla
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12822389/
Mar 2026
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Mitochondrial lactate venting limits oxidative stress

1
1. scibot 26 Mar 2026
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.cmet.2026.02.020
  
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sciencedirect.com/science/article/pii/S1550413126000938
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Oligodendrocyte-encoded lactate dehydrogenase A couples glycolysis to remyelination via protein lactylation

1
1. scibot 17 Mar 2026
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.neuron.2026.02.032
  
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sciencedirect.com/science/article/pii/S0896627326001376
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AARS1-mediated lactylation of STAT1 drives immune evasion

1
1. scibot 17 Mar 2026
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.celrep.2026.117094
  
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sciencedirect.com/science/article/pii/S2211124726001725
Feb 2026
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Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration

1
1. scibot 12 Feb 2026
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.isci.2026.114792
  
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sciencedirect.com/science/article/pii/S2589004226001677
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination

1
1. scibot 30 Jan 2026
  
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  AB_2868521
  
  DOI: 10.7150/ijbs.125009
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12839083/
Nov 2025
54.241.53.176 54.241.53.176

ssrn-5691051-html.html

1
1. scibot 11 Nov 2025
  
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  RRID:AB_2868530
  
  DOI: 10.1016/j.molmed.2018.11.005
  
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54.241.53.176/64713c65fcc1216b83fddb214e5f4f3dbce54cd7/ssrn-5691051-html.html
Aug 2025
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A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma

1
1. scibot 20 Aug 2025
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.xcrm.2025.102292
  
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sciencedirect.com/science/article/pii/S2666379125003659
Jun 2025
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Lactate regulates cell differentiation of erythroid progenitor cells via histone lactylation modification

1
1. scibot 21 Jun 2025
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.isci.2025.112842
  
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sciencedirect.com/science/article/pii/S2589004225011034
May 2025
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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

1
1. scibot 18 May 2025
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.neuron.2025.04.003
  
  Resource: (PTM BIO Cat# PTM-1401, RRID:AB_2868521)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S0896627325002594
Feb 2025
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Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice

7
1. scibot 07 Feb 2025
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.devcel.2024.12.021
  
  Resource: (PTM BIO Cat# PTM-1401, RRID:AB_2868521)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2868521
  
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2. scibot 06 Feb 2025
  
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  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
3. scibot 05 Feb 2025
  
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  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
4. scibot 04 Feb 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
5. scibot 03 Feb 2025
  
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  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
6. scibot 02 Feb 2025
  
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  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
7. scibot 01 Feb 2025
  
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  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
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URL

sciencedirect.com/science/article/pii/S1534580724007603
Jan 2025
www.sciencedirect.com www.sciencedirect.com

Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice

25
1. scibot 31 Jan 2025
  
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  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
2. scibot 30 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
3. scibot 29 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
4. scibot 28 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
5. scibot 27 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
6. scibot 26 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
7. scibot 25 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
8. scibot 24 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
9. scibot 23 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
10. scibot 22 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
11. scibot 21 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
12. scibot 20 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
13. scibot 19 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
14. scibot 18 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
15. scibot 17 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
16. scibot 16 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
17. scibot 15 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
18. scibot 14 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
19. scibot 13 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
20. scibot 12 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
21. scibot 11 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
22. scibot 10 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
23. scibot 09 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
24. scibot 08 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
25. scibot 07 Jan 2025
  
  in Public
  
  RRID:AB_2868521
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:AB_2868521
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sciencedirect.com/science/article/pii/S1534580724007603
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma

1
1. scibot 14 Jul 2024
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.isci.2024.110188
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233973/
May 2024
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Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation

1
1. scibot 14 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114180
  
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sciencedirect.com/science/article/pii/S2211124724005084
Apr 2024
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis

1
1. scibot 23 Apr 2024
  
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  DOI: 10.1016/j.cell.2024.04.002
  
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sciencedirect.com/science/article/pii/S0092867424003970
Jan 2024
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Augmentation of scleral glycolysis promotes myopia through histone lactylation

1
1. scibot 19 Jan 2024
  
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  RRID:AB_2868521
  
  DOI: 10.1016/j.cmet.2023.12.023
  
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sciencedirect.com/science/article/pii/S1550413123004746
Dec 2023
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Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells

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1. scibot 23 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108645
  
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BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.devcel.2023.11.018
  
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Nov 2023
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Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization

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1. scibot 18 Nov 2023
  
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  DOI: 10.1210/endocr/bqad169
  
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  DOI: 10.1210/endocr/bqad169
  
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Aug 2023
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The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity

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  DOI: 10.1016/j.cmet.2023.07.005
  
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Jul 2023
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.cmet.2023.06.013
  
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Feb 2023
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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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1. scibot 02 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112033
  
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Aug 2022
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Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia–Reperfusion Injury Rats

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1. scibot 30 Aug 2022
  
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  DOI: 10.1007/s10571-022-01277-6
  
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Jun 2022
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Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells

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1. scibot 22 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110986
  
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Mar 2022
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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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1. scibot 26 Mar 2022
  
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  DOI: 10.1016/j.molcel.2022.02.033
  
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Oct 2021
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Protein lactylation induced by neural excitation

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  DOI: 10.1016/j.celrep.2021.109820
  
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Aug 2021
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Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE

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1. scibot 16 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.021
  
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May 2021
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Dynamic profiles and transcriptional preferences of histone modifications during spermiogenesis

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1. scibot 10 May 2021
  
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  DOI: 10.1210/endocr/bqaa210
  
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