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Blood metabolic panels for identifying significant fibrosis and inflammation in patients with MASLD

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sciencedirect.com:5037/science/article/pii/S2666379125005956
Nov 2025
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Fluorinated prodrug-engineered nano-remodeler relieves tumor hypoxia for dual-enhanced ferroptosis-immunotherapy

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Aug 2025
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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers

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Jul 2025
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Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules

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1-s2.0-S2589004225014282-main-html.html

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Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion

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Jun 2025
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Comprehensive immune ageing reveals TREM2/TIM3 myeloid cells drive brain immune evasion

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Apr 2025
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BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity

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Mar 2025
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Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

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Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer

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Feb 2025
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A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis

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C/EBPa confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress-induced ferroptosis in FLT3-mutant leukemia

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aacrjournals.org/cancerdiscovery/article/13/7/1720/727640/C-EBP-Confers-Dependence-to-Fatty-Acid-Anabolic
Nov 2024
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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

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1. scibot 11 Nov 2024
  
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Sep 2024
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Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell

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Jun 2024
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Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression

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  DOI: 10.1038/s41522-024-00520-w
  
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Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule

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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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  DOI: 10.1016/j.celrep.2024.114289
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
Mar 2024
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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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cell.com/cell/fulltext/S0092-8674(24)00224-1
Feb 2024
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Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs

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Dec 2023
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Comparing HD knockin pigs and mice reveals the pathological role of IL-17

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Sep 2023
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Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I

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Aug 2023
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Commensal bacteria promote azathioprine therapy failure in inflammatory bowel disease via decreasing 6-mercaptopurine bioavailability

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Jul 2023
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Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy

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Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH

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cd-22-0411-html.html

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Jun 2023
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DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

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HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery

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May 2023
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Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity

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Apr 2023
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The importance of the timing of microbial signals for perinatal immune system development

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  DOI: 10.20517/mrr.2023.03
  
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oaepublish.com/mrr/article/view/5618
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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

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  DOI: 10.1016/j.celrep.2023.112186
  
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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

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  DOI: 10.1016/j.ccell.2023.03.002
  
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Mar 2023
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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.cmet.2023.02.013
  
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sciencedirect.com/science/article/pii/S1550413123000499
Feb 2023
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Recombinant vesicular stomatitis virus-vectored vaccine induces long lasting immunity against Nipah virus disease

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1. scibot 08 Feb 2023
  
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  DOI: 10.1172/JCI164946
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9888376/
Dec 2022
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Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in CD4+ T lymphocytes in HIV-infected immune non-responders

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1. scibot 05 Dec 2022
  
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  DOI: 10.1016/j.ebiom.2022.104382
  
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sciencedirect.com/science/article/pii/S2352396422005643
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RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice

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1. scibot 02 Dec 2022
  
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  DOI: 10.1007/s10238-022-00960-8
  
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link.springer.com/article/10.1007/s10238-022-00960-8
Nov 2022
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STAT3 promotes differentiation of monocytes to MDSCs via CD39/CD73-adenosine signal pathway in oral squamous cell carcinoma

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1. scibot 29 Nov 2022
  
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  DOI: 10.1007/s00262-022-03336-9
  
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link.springer.com/article/10.1007/s00262-022-03336-9
Nov 2021
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Production of human CAR-NK cells with lentiviral vectors and functional assessment in vitro

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1. scibot 18 Nov 2021
  
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  DOI: 10.1016/j.xpro.2021.100956
  
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sciencedirect.com/science/article/pii/S2666166721006626
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

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1. scibot 27 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.08.002
  
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Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.celrep.2021.109525
  
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Jul 2021
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Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides

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1. scibot 07 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109312
  
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Jun 2021
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Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

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1. scibot 24 Jun 2021
  
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  DOI: 10.1016/j.isci.2021.102619
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8193615/
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Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing

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  DOI: 10.1016/j.isci.2021.102404
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8169801/
May 2021
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Repression of endogenous retroviruses prevents antiviral immune response and is required for mammary gland development

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  DOI: 10.1016/j.stem.2021.04.030
  
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Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver

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  DOI: 10.1016/j.ccell.2021.03.004
  
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Apr 2021
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Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

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  DOI: 10.7554/eLife.63632
  
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Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

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1. scibot 14 Apr 2021
  
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  DOI: 10.1016/j.cmet.2021.03.023
  
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cell.com/cell-metabolism/fulltext/S1550-4131(21)00130-3