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IL-2/IL-15 signaling induces NK cell production of FLT3LG augmenting anti-PD-1 immunotherapy

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1. scibot 06 Nov 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-1259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12582536/
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Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.004
  
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sciencedirect.com/science/article/pii/S1074761325004340
Aug 2025
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Lymphoma accelerates T cell and tissue aging

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.023
  
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sciencedirect.com/science/article/pii/S1535610825003290
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Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor control

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1. scibot 06 Aug 2025
  
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  DOI: 10.1016/j.cmet.2025.07.006
  
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sciencedirect.com/science/article/pii/S155041312500333X
Jul 2025
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.018
  
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sciencedirect.com/science/article/pii/S1074761325002870
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Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.018
  
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cell.com/cell/fulltext/S0092-8674(25)00684-1
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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.001
  
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sciencedirect.com/science/article/pii/S1074761325002481
Jun 2025
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Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.025
  
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sciencedirect.com/science/article/pii/S1074761325002468
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A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115902
  
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sciencedirect.com/science/article/pii/S2211124725006734
May 2025
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The tetravalent, bispecific properties of FS118, an anti-LAG-3/PD-L1 antibody, mediate LAG-3 shedding from CD4+ and CD8+ tumor-infiltrating lymphocytes

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1. scibot 16 May 2025
  
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  DOI: 10.1097/CAD.0000000000001705
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12061380/
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

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1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.ccell.2025.02.001
  
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sciencedirect.com/science/article/pii/S1535610825000534
Dec 2024
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Hyperreactive B cells instruct their elimination by T cells to curb autoinflammation and lymphomagenesis

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1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.023
  
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cell.com/immunity/abstract/S1074-7613(24)00538-7
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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.10.044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
Sep 2024
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mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101717
  
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sciencedirect.com/science/article/pii/S2666379124004385
Aug 2024
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Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114632
  
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sciencedirect.com/science/article/pii/S2211124724009823
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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.cell.2024.07.016
  
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sciencedirect.com/science/article/pii/S0092867424007761
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Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.cmet.2024.07.006
  
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sciencedirect.com/science/article/pii/S1550413124002778
Jun 2024
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Insulin and leptin oscillations license food-entrained browning and metabolic flexibility

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114390
  
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sciencedirect.com/science/article/pii/S2211124724007186
Mar 2024
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.013
  
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sciencedirect.com/science/article/pii/S1535610824000576
Dec 2023
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Oral tolerance to systemic vaccination remains intact without RORγt expression in regulatory T cells

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1. scibot 21 Dec 2023
  
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  RRID:AB_2870090
  
  DOI: 10.1016/j.isci.2023.108504
  
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sciencedirect.com/science/article/pii/S2589004223025816
Oct 2023
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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.xcrm.2023.101244
  
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sciencedirect.com/science/article/pii/S2666379123004214
Jun 2023
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Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.immuni.2023.05.005
  
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sciencedirect.com/science/article/pii/S1074761323002224
May 2023
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

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1. scibot 12 May 2023
  
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  DOI: 10.1016/j.ccell.2023.04.010
  
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sciencedirect.com/science/article/pii/S1535610823001368
Apr 2023
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Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

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1. scibot 14 Apr 2023
  
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  DOI: 10.1016/j.ccell.2023.03.015
  
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sciencedirect.com/science/article/pii/S1535610823000880
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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

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1. scibot 07 Apr 2023
  
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  DOI: 10.1016/j.cell.2023.03.011
  
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cell.com/cell/fulltext/S0092-8674(23)00271-4
Feb 2023
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Infection induces tissue-resident memory NK cells that safeguard tissue health

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1. scibot 15 Feb 2023
  
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  DOI: 10.1016/j.immuni.2023.01.016
  
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sciencedirect.com/science/article/pii/S1074761323000262
Jan 2023
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CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

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1. scibot 04 Jan 2023
  
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  DOI: 10.1016/j.xcrm.2022.100878
  
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sciencedirect.com/science/article/pii/S2666379122004426
Jun 2022
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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

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1. scibot 03 Jun 2022
  
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  RRID:AB_2870090
  
  DOI: 10.1016/j.chom.2022.05.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9841318/
Nov 2021
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Mice with diverse microbial exposure histories as a model for preclinical vaccine testing

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1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.chom.2021.10.001
  
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sciencedirect.com/science/article/pii/S1931312821004637
Sep 2021
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Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling

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1. scibot 25 Sep 2021
  
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  DOI: 10.1016/j.immuni.2021.09.003
  
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sciencedirect.com/science/article/pii/S1074761321003666
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A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

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1. scibot 22 Sep 2021
  
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  DOI: 10.1016/j.immuni.2021.08.029
  
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sciencedirect.com/science/article/pii/S1074761321003630
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Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors

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1. scibot 18 Sep 2021
  
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  DOI: 10.1016/j.cell.2021.08.020
  
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sciencedirect.com/science/article/pii/S0092867421009946
Jul 2021
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Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

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1. scibot 07 Jul 2021
  
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  DOI: 10.1016/j.immuni.2021.06.007
  
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sciencedirect.com/science/article/pii/S107476132100251X