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FAM134B-mediated ER-phagy degrades APP and suppresses Alzheimer’s disease pathology

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1. scibot 08 Jul 2026
  
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  DOI: 10.1038/s44318-026-00818-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13324857/
May 2026
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PATZ1 condensation adjacent to PML nuclear bodies suppresses HBoV transcription as an intrinsic antiviral defense

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1. scibot 30 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117437
  
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sciencedirect.com/science/article/pii/S2211124726005152
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Design principles of a membrane-spanning ubiquitin ligase

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.molcel.2026.05.001
  
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S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

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  DOI: 10.1016/j.molcel.2026.04.016
  
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sciencedirect.com/science/article/pii/S1097276526002704
Apr 2026
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Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation

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1. scibot 17 Apr 2026
  
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  DOI: 10.1016/j.immuni.2026.03.019
  
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advs74967-sup-0001-suppmat.docx-html.html

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1. scibot 11 Apr 2026
  
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The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma

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1. scibot 01 Apr 2026
  
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  DOI: 10.1186/s13046-026-03673-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13032475/
Jan 2026
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Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression

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1. scibot 27 Jan 2026
  
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Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle

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1. scibot 22 Jan 2026
  
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  DOI: 10.1083/jcb.202404025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11737348/
Dec 2025
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ZAP inhibits double-stranded RNA virus infection by degrading negative-strand RNA and blocking the elongation phase of viral protein synthesis

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116742
  
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sciencedirect.com:5037/science/article/pii/S2211124725015141
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A gut-secreted histidine methyltransferase enforces cross-kingdom catalytic antifungal defense

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1. scibot 18 Dec 2025
  
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  DOI: 10.1016/j.chom.2025.11.015
  
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Potentiating immunotherapy in “immune-cold” solid tumors through orchestrating T cell immunity via tumor-specific genetic engineering

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1. scibot 17 Dec 2025
  
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  DOI: 10.1016/j.xcrm.2025.102510
  
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sciencedirect.com:5037/science/article/pii/S266637912500583X
Nov 2025
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Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116620
  
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TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics

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1. scibot 06 Nov 2025
  
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  DOI: 10.1016/j.chembiol.2025.10.003
  
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sciencedirect.com/science/article/pii/S245194562500340X
Oct 2025
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Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells

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1. scibot 18 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116448
  
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sciencedirect.com/science/article/pii/S2211124725012197
Sep 2025
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Sigma-1 receptor counteracts non-cell-autonomous poly-PR-induced astrocytic oxidative stress in C9orf72 ALS

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1. scibot 23 Sep 2025
  
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  DOI: 10.1016/j.redox.2025.103875
  
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Biomolecular condensates of ATG18 reshape ER for autophagy in plants

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1. scibot 12 Sep 2025
  
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  DOI: 10.1016/j.devcel.2025.08.013
  
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sciencedirect.com/science/article/pii/S1534580725005337
Jun 2025
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Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.cmet.2025.05.013
  
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Sigma-1R–Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS

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1. scibot 12 Jun 2025
  
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  DOI: 10.1016/j.nbd.2025.106992
  
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sciencedirect.com/science/article/pii/S0969996125002086
May 2025
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Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.chom.2025.04.022
  
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sciencedirect.com/science/article/pii/S1931312825001556
Apr 2025
www.biorxiv.org www.biorxiv.org

The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters

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1. scibot 03 Apr 2025
  
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  DOI: 10.1101/2025.03.25.645338
  
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biorxiv.org/content/10.1101/2025.03.25.645338v1
Feb 2025
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STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma

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Dec 2024
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Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

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1. scibot 21 Dec 2024
  
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  DOI: 10.1038/s41586-024-08348-2
  
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nature.com/articles/s41586-024-08348-2
Nov 2024
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wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html

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1. scibot 14 Nov 2024
  
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  DOI: 10.1038/s44318-024-00290-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11649922/
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Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

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1. scibot 14 Nov 2024
  
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  DOI: 10.1038/s44318-024-00290-3
  
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embopress.org/doi/10.1038/s44318-024-00290-3
Oct 2024
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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

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1. scibot 05 Oct 2024
  
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  DOI: 10.1016/j.isci.2024.110882
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440251/
Jun 2024
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Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification

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1. scibot 27 Jun 2024
  
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  DOI: 10.1038/s41596-024-01006-x
  
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link.springer.com/article/10.1038/s41596-024-01006-x
May 2024
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Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

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  DOI: 10.1016/j.cmet.2024.04.018
  
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Jan 2024
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Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation

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  DOI: 10.1016/j.xgen.2023.100471
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10794847/
Dec 2023
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Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin

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  DOI: 10.1016/j.celrep.2023.113511
  
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An Arabidopsis Rab18 GTPase promotes autophagy by tethering ATG18a to the ER in response to nutrient starvation

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  DOI: 10.1016/j.devcel.2023.11.006
  
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Multiple enzymatic activities of a Sir2-HerA system cooperate for anti-phage defense

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.010
  
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sciencedirect.com/science/article/pii/S1097276523009553
Nov 2023
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The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy

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  DOI: 10.1016/j.celrep.2023.113342
  
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Oct 2023
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Regulation of STING activity in DNA sensing by ISG15 modification

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113277
  
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sciencedirect.com/science/article/pii/S2211124723012895
Aug 2023
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Inhibition of FNDC1 suppresses gastric cancer progression by interfering with Gβγ-VEGFR2 complex formation

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1. scibot 27 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107534
  
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LncRNA DGCR5-encoded polypeptide RIP aggravates SONFH by repressing nuclear localization of β-catenin in BMSCs

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1. scibot 18 Aug 2023
  
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2. scibot 16 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112969
  
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Mar 2023
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BPS Publications

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1. scibot 03 Mar 2023
  
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  DOI: 10.1111/bph.16036
  
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Feb 2023
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Cofilin promotes tau pathology in Alzheimer’s disease

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  DOI: 10.1016/j.celrep.2023.112138
  
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Jan 2023
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A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex

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  DOI: 10.1016/j.str.2022.11.002
  
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Apr 2022
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The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy

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Oct 2021
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Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod

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  DOI: 10.1016/j.celrep.2021.109761
  
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May 2021
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UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model

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  DOI: 10.1016/j.neuron.2021.04.023
  
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