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Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia

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1. scibot 21 Oct 2025
  
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  DOI: 10.1126/sciadv.adx8662
  
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science.org/doi/10.1126/sciadv.adx8662
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia

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1. scibot 21 Oct 2025
  
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  DOI: 10.1126/sciadv.adx8662
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12525776/
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Loss of SMN Impairs Osteoblast–Osteoclast Coupling via IGF1–Akt–OPG Axis in Spinal Muscular Atrophy

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1. scibot 16 Oct 2025
  
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  DOI: 10.1096/fj.202501626R
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12516799/
Aug 2025
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The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.010
  
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sciencedirect.com/science/article/pii/S1534580725004484
Jun 2025
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Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis

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  DOI: 10.1016/j.devcel.2025.05.016
  
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sciencedirect.com/science/article/pii/S1534580725003272
May 2025
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SPT6 regulates H3K14Ac deposition in mouse embryonic stem cells

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115757
  
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sciencedirect.com/science/article/pii/S2211124725005285
Apr 2025
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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.cmet.2025.03.006
  
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sciencedirect.com/science/article/pii/S1550413125001093
Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.devcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1534580725001212
Jan 2025
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Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation

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1. scibot 03 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115117
  
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sciencedirect.com/science/article/pii/S2211124724014682
Oct 2024
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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

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1. scibot 05 Oct 2024
  
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  DOI: 10.1016/j.isci.2024.110882
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440251/
Sep 2024
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Targeting ALDOA to Modulate Tumorigenesis and Energy Metabolism in Retinoblastoma

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110725
  
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sciencedirect.com/science/article/pii/S2589004224019503
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S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

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1. scibot 18 Sep 2024
  
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  DOI: 10.7554/eLife.94302
  
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elifesciences.org/articles/94302
Jul 2024
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A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.07.003
  
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sciencedirect.com/science/article/pii/S1931312824002622
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma

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1. scibot 27 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11270646/
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MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110163
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11226984/
May 2024
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HuR promotes triglyceride synthesis and intestinal fat absorption

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114238
  
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sciencedirect.com/science/article/pii/S2211124724005667
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TERC promotes non-small cell lung cancer progression by facilitating the nuclear localization of TERT

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1. scibot 09 May 2024
  
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  DOI: 10.1016/j.isci.2024.109869
  
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52.53.155.43/761c70660e3a03a822484173742c13c4c44cc6bf/PIIS2589004224010915-html.html
Feb 2024
dx.doi.org dx.doi.org

Lifespan Effects of Muscle-Specific Androgen Receptor Overexpression on Body Composition of Male and Female Rats

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1. scibot 15 Feb 2024
  
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  DOI: 10.1210/endocr/bqae012
  
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dx.doi.org/10.1210/endocr/bqae012
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DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.109016
  
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sciencedirect.com/science/article/pii/S2589004224002372
Jan 2024
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Exercise enhances placental labyrinth trophoblast development by activation of PGC-1α and FNDC5/irisin

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1. scibot 25 Jan 2024
  
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  DOI: 10.1093/biolre/ioad151
  
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academic.oup.com/biolreprod/advance-article-abstract/doi/10.1093/biolre/ioad151/7338767
52.53.155.43 52.53.155.43

Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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1. scibot 10 Jan 2024
  
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  DOI: 10.1126/sciimmunol.abq2424
  
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52.53.155.43/93ebbe5a83b6a28b0d01edad42fa81f437079176/sciimmunol.abq2424_sm-html.html
Dec 2023
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Grass carp reovirus VP56 and VP35 induce formation of viral inclusion bodies for replication

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1. scibot 19 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108684
  
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sciencedirect.com/science/article/pii/S258900422302761X
Oct 2023
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HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.intimp.2023.110950
  
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sciencedirect.com/science/article/pii/S1567576923012754
Aug 2023
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The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112968
  
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  DOI: 10.1016/j.celrep.2023.112968
  
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52.53.155.43/8a075ef675e11ca05cb4fe9fd629f036036ec570/PIIS2211124723009798-html.html
Jul 2023
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Magneto-mechanical stimulation modulates osteocyte fate via the ECM-integrin-CSK axis and wnt pathway

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107365
  
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sciencedirect.com/science/article/pii/S2589004223014426
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T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity

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  DOI: 10.1016/j.celrep.2023.112797
  
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sciencedirect.com/science/article/pii/S2211124723008082
Apr 2023
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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  DOI: 10.1016/j.celrep.2023.112316
  
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sciencedirect.com/science/article/pii/S2211124723003273
Mar 2023
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Mitoguardin2 is Associated with Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells

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1. scibot 29 Mar 2023
  
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  DOI: 10.1210/jendso/bvad034
  
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academic.oup.com/jes/article/7/5/bvad034/7059540
journals.lww.com journals.lww.com

Adipose mesenchymal stem cell-derived extracellular... : Neural Regeneration Research

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1. scibot 24 Mar 2023
  
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  DOI: 10.4103/1673-5374.369123
  
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journals.lww.com/nrronline/Fulltext/2023/10000/Adipose_mesenchymal_stem_cell_derived.39.aspx
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8

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1. scibot 22 Mar 2023
  
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  DOI: 10.1158/2767-9764.CRC-22-0344
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10026737/
Jan 2023
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Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress

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1. scibot 06 Jan 2023
  
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  DOI: 10.1016/j.isci.2022.105740
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9804114/
Dec 2022
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Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT

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1. scibot 11 Dec 2022
  
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  DOI: 10.1016/j.cell.2022.11.014
  
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sciencedirect.com/science/article/pii/S009286742201457X
Nov 2022
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Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size

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1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111640
  
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sciencedirect.com/science/article/pii/S221112472201511X
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Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis

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1. scibot 05 Nov 2022
  
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  DOI: 10.1016/j.ebiom.2022.104312
  
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sciencedirect.com/science/article/pii/S2352396422004947
Sep 2022
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CDK14 inhibition reduces mammary stem cell activity and suppresses triple negative breast cancer progression

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1. scibot 15 Sep 2022
  
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  RRID:AB_2881629
  
  DOI: 10.1016/j.celrep.2022.111331
  
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sciencedirect.com/science/article/pii/S2211124722011597
Jun 2022
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Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies

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1. scibot 17 Jun 2022
  
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  RRID:AB_2881629
  
  DOI: 10.1016/j.cmet.2022.05.010
  
  Resource: (Proteintech Cat# 66240-1-Ig, RRID:AB_2881629)
  
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sciencedirect.com/science/article/pii/S1550413122001929
Dec 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

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1. scibot 01 Dec 2021
  
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  RRID:AB_2881629
  
  DOI: 10.1016/j.ebiom.2021.103712
  
  Resource: (Proteintech Cat# 66240-1-Ig, RRID:AB_2881629)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8613501/
Nov 2021
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MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal

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1. scibot 03 Nov 2021
  
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  RRID:AB_2881629
  
  DOI: 10.1016/j.celrep.2021.109949
  
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sciencedirect.com/science/article/pii/S2211124721014261
Aug 2021
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Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6

1
1. scibot 07 Aug 2021
  
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  RRID:AB_2881629
  
  DOI: 10.1016/j.chembiol.2021.07.012
  
  Resource: (Proteintech Cat# 66240-1-Ig, RRID:AB_2881629)
  
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sciencedirect.com/science/article/pii/S2451945621003524