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SETD2 Deficiency Drives Mitochondrial DNA Leakage and Creates a Druggable Dependency on BCL-xL in Clear Cell Renal Cell Carcinoma

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1. scibot 10 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3195
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13244386/
May 2026
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Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117409
  
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sciencedirect.com/science/article/pii/S2211124726004870
Mar 2026
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MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution

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1. scibot 13 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117059
  
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sciencedirect.com/science/article/pii/S2211124726001373
Feb 2026
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Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosis in EAE mice

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.intimp.2026.116364
  
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sciencedirect.com/science/article/pii/S1567576926002080
Dec 2025
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Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING

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1. scibot 18 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116745
  
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sciencedirect.com:5037/science/article/pii/S2211124725015177
Nov 2025
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Herpes simplex virus type 1 disseminates from the cornea to the CNS in mice by thwarting type III interferon immune defenses

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116581
  
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sciencedirect.com/science/article/pii/S2211124725013531
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
Jun 2025
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Senescence-resistant human mesenchymal progenitor cells counter aging in primates

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.021
  
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sciencedirect.com/science/article/pii/S0092867425005719
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Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer

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1. scibot 04 Jun 2025
  
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  DOI: 10.1038/s41598-025-03924-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12127464/
Mar 2025
www.cell.com www.cell.com

Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115441
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00212-8
Feb 2025
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Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses

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1. scibot 21 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.027
  
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sciencedirect.com/science/article/pii/S1097276525000619
Jan 2025
52.53.155.43 52.53.155.43

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1. scibot 31 Jan 2025
  
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  DOI: 10.1371/journal.ppat.1012206
  
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52.53.155.43/c74348c45bccaf197fb20d31d8b35ab413c8424c/PDF-html.html
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Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS immune sensing

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1. scibot 31 Jan 2025
  
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  DOI: 10.1371/journal.ppat.1012206
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11793794/
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Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115202
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11829653/
Aug 2024
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.08.006
  
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sciencedirect.com/science/article/pii/S1097276524006609
Jul 2024
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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

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1. scibot 23 Jul 2024
  
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  DOI: 10.1111/acel.14258
  
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onlinelibrary.wiley.com/doi/10.1111/acel.14258
Apr 2024
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ISGylation by HERCs facilitates STING activation

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1. scibot 23 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114135
  
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sciencedirect.com/science/article/pii/S2211124724004637
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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114088
  
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sciencedirect.com/science/article/pii/S2211124724004169
Nov 2023
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Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.immuni.2023.09.012
  
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sciencedirect.com/science/article/abs/pii/S107476132300417X
Oct 2023
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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.molcel.2023.09.007
  
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sciencedirect.com/science/article/pii/S1097276523007025
Sep 2023
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Spinal TAOK2 contributes to neuropathic pain via cGAS-STING activation in rats

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1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107792
  
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sciencedirect.com/science/article/pii/S2589004223018692
Aug 2023
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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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1. scibot 25 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113040
  
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sciencedirect.com/science/article/pii/S2211124723010513
Nov 2022
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Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111681
  
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sciencedirect.com/science/article/pii/S2211124722015558
Sep 2022
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Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase

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1. scibot 08 Sep 2022
  
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  RRID:AB_2920551
  
  DOI: 10.1016/j.celrep.2022.111310
  
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sciencedirect.com/science/article/pii/S2211124722011342