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Oligodendrocyte-encoded lactate dehydrogenase A couples glycolysis to remyelination via protein lactylation

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.neuron.2026.02.032
  
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sciencedirect.com/science/article/pii/S0896627326001376
Jan 2026
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AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapy

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  DOI: 10.1016/j.cell.2025.12.039
  
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Proteomic Landscape of Sweat Glands in Neuronal Intranuclear Inclusion Disease Reveals a Pathogenic Triad of Abnormal Autophagy, Mitochondrial Dysfunction, and a Failed Oxidative Stress Response

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  DOI: 10.1111/jnc.70352
  
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The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis

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  DOI: 10.1038/s41467-026-68492-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12820292/
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SNAP23 deficiency triggers Trim21 mitochondrial translocation to suppress TFAM-mediated oxidative metabolism and drive chemoresistance in colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12811313/
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p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116769
  
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sciencedirect.com/science/article/pii/S2211124725015414
Dec 2025
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Mitochondrial glutamine import sustains electron transport chain integrity independently of glutaminolysis in cancer

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ZAP inhibits double-stranded RNA virus infection by degrading negative-strand RNA and blocking the elongation phase of viral protein synthesis

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TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1

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Nov 2025
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Depletion of LINC01133 from cancer-associated fibroblasts exacerbates the progression of gastric adenocarcinoma

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  DOI: 10.1016/j.isci.2025.113886
  
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Liquid-liquid phase separation of ATXN2L enhances mRNA translation in hepatocellular carcinoma

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1. scibot 22 Nov 2025
  
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BPS Publications

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1. scibot 13 Nov 2025
  
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  DOI: 10.1111/bph.70220
  
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Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation

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1. scibot 01 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.007
  
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sciencedirect.com/science/article/pii/S1074761325004613
Oct 2025
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Structural assembly of the subcortical maternal complex SCMC

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  DOI: 10.1016/j.str.2025.09.009
  
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1-s2.0-S258900422502036X-main-html.html

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Sep 2025
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CPNE5 Overexpression Inhibits Cardiomyocytes Apoptosis by Promoting the Degradation of FAS Receptor

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  DOI: 10.1016/j.isci.2025.113302
  
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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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1. scibot 04 Sep 2025
  
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  DOI: 10.7554/eLife.103904
  
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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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1. scibot 03 Sep 2025
  
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Aug 2025
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BPS Publications

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1. scibot 27 Aug 2025
  
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  DOI: 10.1111/bph.70175
  
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TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity

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  DOI: 10.1186/s13046-025-03513-5
  
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USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24

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The Tacrine‐Induced Endoplasmic Reticulum Stress in AChE‐Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose

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pmc.ncbi.nlm.nih.gov/articles/PMC12322807/
Jun 2025
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kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html

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1. scibot 28 Jun 2025
  
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52.53.155.43/f797b68cc578c5707d96baf6b2dcdbd6b1b6aadb/kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html
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Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila

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VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

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Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

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May 2025
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Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

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Apr 2025
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Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity

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  DOI: 10.1016/j.xcrm.2025.102079
  
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O-GlcNAcylation-mediated endothelial metabolic memory contributes to cardiac damage via small extracellular vesicles

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BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity

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  DOI: 10.1016/j.celrep.2025.115493
  
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LAMP2A-mediated neuronal hyperexcitability by enhancing NKAβ1 degradation underlies depression-induced allodynia

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  DOI: 10.1016/j.celrep.2025.115489
  
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Discovery of targeting USP10-mediated proline metabolism arrangement to inhibit hepatocellular carcinoma progression

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  DOI: 10.1016/j.bcp.2025.116904
  
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Mar 2025
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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

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  DOI: 10.1016/j.cmet.2025.02.008
  
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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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Role of HNF4A-AS1/HNRNPC-mediated HNF4A Ubiquitination Protection against Ritonavir-induced Hepatotoxicity

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RIOK3 mediates the degradation of 40S ribosomes

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STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma

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Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

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Cutin formation in tomato is controlled by a multipartite module of synergistic and antagonistic transcription factors

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Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling

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Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals

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ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma

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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

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A pro-metastatic tRNA fragment drives aldolase A oligomerization to enhance aerobic glycolysis in lung adenocarcinoma

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Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma

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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer

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CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1

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Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin

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Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell

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Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis

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JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia

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Jul 2023
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An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation

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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

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May 2023
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Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation

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A non-canonical target-binding site in Munc18-1 domain 3b for assembling the Mint1-Munc18-1-syntaxin-1 complex

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