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Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.023
  
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sciencedirect.com/science/article/pii/S1097276526000651
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency

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1. scibot 14 Jan 2026
  
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  DOI: 10.1158/2643-3230.BCD-25-0112
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12793833/
Dec 2025
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Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5

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1. scibot 06 Dec 2025
  
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  RRID:AB_2923178
  
  DOI: 10.1186/s13072-025-00644-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12676786/
Nov 2025
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Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116572
  
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sciencedirect.com/science/article/pii/S2211124725013440
Aug 2025
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Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

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1. scibot 20 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.020
  
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sciencedirect.com/science/article/pii/S1534580725004964
Jul 2025
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Complete loss of PAX4 causes transient neonatal diabetes in humans

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.molmet.2025.102201
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12275979/
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1-s2.0-S0016508525057324-main-html.html

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1. scibot 08 Jul 2025
  
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  RRID:AB_2923178
  
  DOI: 10.1053/j.gastro.2025.07.003
  
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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
Jun 2025
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CRAMP1 drives linker histone expression to enable Polycomb repression

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.031
  
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sciencedirect.com/science/article/pii/S1097276525004708
May 2025
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Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans

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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.01.25324926
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998800/
Feb 2025
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Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia

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1. scibot 27 Feb 2025
  
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  DOI: 10.1101/2025.01.21.25320683
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
Dec 2024
www.cell.com www.cell.com

Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice

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1. scibot 29 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.11.022
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00722-6
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Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers

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1. scibot 11 Dec 2024
  
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  DOI: 10.1158/2159-8290.CD-23-0866
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11609823/
www.biorxiv.org www.biorxiv.org

Transcriptional Regulation of Mammary Alveolar Proliferation and Differentiation during Early Pregnancy

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1. scibot 03 Dec 2024
  
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  RRID:AB_2923178
  
  DOI: 10.1101/2024.11.27.625731
  
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biorxiv.org/content/10.1101/2024.11.27.625731v1
Oct 2024
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Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.chembiol.2024.09.004
  
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sciencedirect.com/science/article/pii/S2451945624003969
Aug 2024
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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

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1. scibot 23 Aug 2024
  
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  AB_2923178
  
  DOI: 10.1016/j.devcel.2024.07.021
  
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sciencedirect.com/science/article/pii/S1534580724004830
Jul 2024
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IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

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1. scibot 24 Jul 2024
  
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  AB_2923178
  
  DOI: 10.1016/j.ccell.2024.05.026
  
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sciencedirect.com/science/article/pii/S1535610824002174
www.cell.com www.cell.com

The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.cmet.2024.06.006
  
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cell.com/cell-metabolism/fulltext/S1550-4131(24)00231-6
Jun 2024
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CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis

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1. scibot 21 Jun 2024
  
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  AB_2923178
  
  DOI: 10.1016/j.celrep.2024.114345
  
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sciencedirect.com/science/article/pii/S2211124724006739
Apr 2024
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Enhancer switching in cell lineage priming is linked to eRNA, Brg1’s AT-hook, and SWI/SNF recruitment

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.molcel.2024.03.013
  
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sciencedirect.com/science/article/pii/S1097276524002235
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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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1. scibot 04 Apr 2024
  
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  AB_2923178
  
  DOI: 10.1016/j.devcel.2024.03.020
  
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sciencedirect.com/science/article/pii/S1534580724001886
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma

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1. scibot 03 Apr 2024
  
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  DOI: 10.1016/j.xcrm.2024.101472
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
Mar 2024
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Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders

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1. scibot 12 Mar 2024
  
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  DOI: 10.1016/j.stem.2024.01.010
  
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sciencedirect.com/science/article/pii/S1934590924000407
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Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis

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1. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113894
  
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sciencedirect.com/science/article/pii/S2211124724002225
Feb 2024
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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1. scibot 02 Feb 2024
  
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  DOI: 10.1016/j.cell.2024.01.008
  
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sciencedirect.com/science/article/pii/S0092867424000102
Jan 2024
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SATB2 organizes the 3D genome architecture of cognition in cortical neurons

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1. scibot 20 Jan 2024
  
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  DOI: 10.1016/j.molcel.2023.12.024
  
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sciencedirect.com/science/article/pii/S1097276523010705
Nov 2023
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Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators

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1. scibot 22 Nov 2023
  
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  DOI: 10.1016/j.xgen.2023.100442
  
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sciencedirect.com/science/article/pii/S2666979X2300277X
Aug 2023
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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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1. scibot 04 Aug 2023
  
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  DOI: 10.1016/j.ccell.2023.07.005
  
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sciencedirect.com/science/article/pii/S1535610823002453
Jul 2023
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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.cmet.2023.06.013
  
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sciencedirect.com/science/article/pii/S1550413123002231
Nov 2022
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Protocol to isolate mature thymic T cell subsets using fluorescence-activated cell sorting for assessing gene expression by RNA-seq and transcription factor binding across the genome by CUT&RUN

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1. scibot 15 Nov 2022
  
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  DOI: 10.1016/j.xpro.2022.101839
  
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sciencedirect.com/science/article/pii/S2666166722007195