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Lactate couples metabolic state to necroptosis across pathological and physiological conditions

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1. scibot 27 Sep 2026
  
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  DOI: 10.1016/j.cmet.2026.08.022
  
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sciencedirect.com/science/article/pii/S1550413126003748
May 2026
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Loss-of-Function (G603R) Lrp10 Fails to Downregulate mRNA of Pathologic α-Synuclein and Causes Neurodegeneration of Substantia Nigra Dopaminergic Cells in Parkinson’s Disease Knockin Mice

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1. scibot 28 May 2026
  
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  DOI: 10.1007/s11064-026-04762-2
  
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link.springer.com/article/10.1007/s11064-026-04762-2
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Lyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-mediated apoptosis and necroptosis

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1. scibot 27 May 2026
  
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  DOI: 10.1016/j.bcp.2026.118094
  
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sciencedirect.com/science/article/pii/S0006295226004296
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A neurovascular survival axis for adult sympathetic neurons

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1. scibot 08 May 2026
  
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  DOI: 10.1016/j.neuron.2026.04.004
  
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sciencedirect.com/science/article/pii/S0896627326002734
Apr 2026
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Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis

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1. scibot 24 Apr 2026
  
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  DOI: 10.1016/j.neuron.2026.03.035
  
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sciencedirect.com/science/article/pii/S0896627326002655
Mar 2026
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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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1. scibot 24 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117134
  
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sciencedirect.com/science/article/pii/S2211124726002123
Feb 2026
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Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116942
  
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sciencedirect.com/science/article/pii/S2211124726000203
Sep 2025
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RIPK1 autophosphorylation at S161 mediates cell death and inflammation

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1. scibot 30 Sep 2025
  
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  DOI: 10.1084/jem.20250279
  
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2. scibot 27 Sep 2025
  
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  RRID:AB_2937060
  
  DOI: 10.1084/jem.20250279
  
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rupress.org/jem/article/222/12/e20250279/278339/RIPK1-autophosphorylation-at-S161-mediates-cell
Jun 2025
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RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.cmet.2025.05.014
  
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sciencedirect.com/science/article/pii/S1550413125002943
Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.04.004
  
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sciencedirect.com/science/article/pii/S1097276525003077
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MLKL activity requires a splicing-regulated, druggable intramolecular interaction

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1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.015
  
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sciencedirect.com/science/article/pii/S109727652500259X
Jul 2024
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Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114400
  
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cell.com/cell-reports/abstract/S2211-1247(24)00728-9
May 2024
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.025
  
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sciencedirect.com/science/article/pii/S1074761324002309
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The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.016
  
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sciencedirect.com/science/article/pii/S1074761324002218
Jan 2024
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PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis

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1. scibot 25 Jan 2024
  
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  RRID:AB_2937060
  
  DOI: 10.1016/j.molcel.2023.12.041
  
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sciencedirect.com/science/article/pii/S1097276523011218