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Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells

1
1. scibot 03 Mar 2026
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.xpro.2026.104398
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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sciencedirect.com/science/article/pii/S2666166726000511
Oct 2025
www.sciencedirect.com www.sciencedirect.com

Ribosome dysregulation and intervention in age-related infertility

1
1. scibot 28 Oct 2025
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.xcrm.2025.102424
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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sciencedirect.com/science/article/pii/S2666379125004975
Sep 2025
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Repeats mimic pathogen-associated patterns across a vast evolutionary landscape

1
1. scibot 25 Sep 2025
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.xgen.2025.101011
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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sciencedirect.com/science/article/pii/S2666979X25002678
www.biorxiv.org www.biorxiv.org

The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

1
1. scibot 16 Sep 2025
  
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  RRID:AB_2941775
  
  DOI: 10.1101/2025.09.09.675047
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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biorxiv.org/content/10.1101/2025.09.09.675047v1
Aug 2025
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LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

2
1. scibot 26 Aug 2025
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.xgen.2025.100979
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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  RRID:AB_2941775
2. scibot 26 Aug 2025
  
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  RRID:RRID:AB_2941775
  
  DOI: 10.1016/j.xgen.2025.100979
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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  RRID:AB_2941775
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sciencedirect.com/science/article/pii/S2666979X25002356
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Memory T‐Cell Phenotype in Cutaneous T‐Cell Lymphoma Is Modified by Germline Gene Gametocyte Specific Factor 1

1
1. scibot 20 May 2025
  
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  RRID:AB_2941775
  
  DOI: 10.1111/exd.70123
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12078864/
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

1
1. scibot 27 Mar 2025
  
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  RRID:AB_2941775
  
  DOI: 10.7554/eLife.96850
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11925450/
Nov 2024
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Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms

1
1. scibot 24 Nov 2024
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.immuni.2024.10.015
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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sciencedirect.com/science/article/pii/S1074761324004941
Apr 2024
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SAFB restricts contact domain boundaries associated with L1 chimeric transcription

1
1. scibot 11 Apr 2024
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.molcel.2024.03.021
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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sciencedirect.com/science/article/pii/S1097276524002314
Feb 2024
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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

1
1. scibot 14 Feb 2024
  
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  RRID:AB_2941775
  
  DOI: 10.1016/j.celrep.2024.113774
  
  Resource: (Sigma-Aldrich Cat# MABC1152, RRID:AB_2941775)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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sciencedirect.com/science/article/pii/S2211124724001025
Nov 2023
www.mdpi.com www.mdpi.com

The Ultraviolet Irradiation of Keratinocytes Induces Ectopic Expression of LINE-1 Retrotransposon Machinery and Leads to Cellular Senescence

1
1. scibot 17 Nov 2023
  
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  RRID:AB_2941775
  
  DOI: 10.3390/biomedicines11113017
  
  Resource: AB_2941775
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_2941775
  
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mdpi.com/2227-9059/11/11/3017