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PRC1 promotes MAFLD progression by regulating glycolysis/lactylation axis and forming a positive feedback loop

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1. scibot 15 Apr 2026
  
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  DOI: 10.1016/j.jnutbio.2026.110378
  
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sciencedirect.com/science/article/pii/S0955286326001208
Apr 2026
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

m5C-Modified tRF3b-CysGCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

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1. scibot 02 Apr 2026
  
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  RRID:AB_2942013
  
  DOI: 10.1002/advs.202522294
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202522294
Mar 2026
pubs.acs.org pubs.acs.org

Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/H3K18la/IGF2BP3 Sequential Regulatory Axis

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1. scibot 31 Mar 2026
  
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  DOI: 10.1021/acs.jafc.5c16242
  
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pubs.acs.org/doi/10.1021/acs.jafc.5c16242
54.241.53.176 54.241.53.176

1-s2.0-S2589004226007479-main-html.html

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.isci.2026.115372
  
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54.241.53.176/e72524355eb321529f4dd9a65278a0820d03292a/1-s2.0-S2589004226007479-main-html.html
www.biorxiv.org www.biorxiv.org

L-Lactate reprograms tumor-associated macrophages to drive pancreatic cancer progression via BCL3 lactylation

1
1. scibot 19 Mar 2026
  
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  DOI: 10.64898/2026.03.06.710237
  
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biorxiv.org/content/10.64898/2026.03.06.710237v1
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Multi-omics and causal inference reveal lactylation-based osteoblast regulatory networks and drug candidates

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1. scibot 25 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114926
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12927281/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

H3K18 lactylation potentiates microglial polarization via the TLR4 pathway in diabetes-induced cognitive impairment

1
1. scibot 14 Feb 2026
  
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  RRID:AB_2942013
  
  DOI: 10.1172/jci.insight.188077
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12890480/
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Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

1
1. scibot 05 Feb 2026
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.chembiol.2026.01.003
  
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sciencedirect.com/science/article/pii/S2451945626000231
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Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer

1
1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.116941
  
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sciencedirect.com/science/article/pii/S2211124726000197
Jan 2026
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Lactylation-driven nuclear RIG-I promoted by lactate transporter inhibitor suppresses DNA damage repair through inhibiting PARP1 activity

1
1. scibot 15 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116854
  
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sciencedirect.com/science/article/pii/S2211124725016262
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

1
1. scibot 04 Dec 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.cmet.2025.11.002
  
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sciencedirect.com:5037/science/article/pii/S1550413125004863
Nov 2025
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Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

1
1. scibot 11 Nov 2025
  
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  DOI: 10.1002/advs.202510733
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510733
Oct 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Characterization of protein lactylation in healthy and ischemic mouse hearts

1
1. scibot 16 Oct 2025
  
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  RRID:AB_2942013
  
  DOI: 10.3389/fcvm.2025.1644886
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12515869/
Aug 2025
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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis

1
1. scibot 14 Aug 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.devcel.2025.07.014
  
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sciencedirect.com/science/article/pii/S153458072500471X
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Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development

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1. scibot 13 Aug 2025
  
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  AB_2942013
  
  DOI: 10.1016/j.cmet.2025.07.008
  
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sciencedirect.com/science/article/pii/S1550413125003353
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TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease

1
1. scibot 01 Aug 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.celrep.2025.116091
  
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sciencedirect.com/science/article/pii/S2211124725008629
Jul 2025
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Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome

1
1. scibot 31 Jul 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.celrep.2025.116084
  
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sciencedirect.com/science/article/pii/S2211124725008551
Jun 2025
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GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer

1
1. scibot 11 Jun 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.celrep.2025.115774
  
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sciencedirect.com/science/article/pii/S2211124725005455
May 2025
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Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory

1
1. scibot 16 May 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.cell.2025.03.048
  
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sciencedirect.com/science/article/pii/S0092867425004003
Apr 2025
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High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy

1
1. scibot 11 Apr 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.celrep.2025.115545
  
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sciencedirect.com/science/article/pii/S221112472500316X
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Halting hepatocellular carcinoma: Identifying intercellular crosstalk in HBV-driven disease

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1. scibot 01 Apr 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.celrep.2025.115457
  
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sciencedirect.com/science/article/pii/S2211124725002281
Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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1. scibot 29 Mar 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.devcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1534580725001212
Feb 2025
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H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment

1
1. scibot 20 Feb 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.jare.2025.02.020
  
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sciencedirect.com/science/article/pii/S2090123225001183
Jan 2025
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Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining

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1. scibot 30 Jan 2025
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.cmet.2024.12.005
  
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sciencedirect.com/science/article/pii/S1550413124004881
Dec 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Post-translational toxin modification by lactate controls Staphylococcus aureus virulence

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1. scibot 21 Dec 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1038/s41467-024-53979-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11561239/
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Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

1
1. scibot 06 Dec 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.cmet.2024.11.005
  
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sciencedirect.com/science/article/pii/S1550413124004510
Nov 2024
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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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1. scibot 24 Nov 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.cmet.2024.10.015
  
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sciencedirect.com/science/article/pii/S155041312400411X
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis

1
1. scibot 05 Oct 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.isci.2024.110911
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440250/
Jul 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224018315-main-html.html

1
1. scibot 30 Jul 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.isci.2024.110606
  
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52.53.155.43/582682e695d3f5ad0dd9dabb130e8edc5e587492/1-s2.0-S2589004224018315-main-html.html
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation

1
1. scibot 24 Jul 2024
  
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  AB_2942013
  
  DOI: 10.1016/j.cmet.2024.05.016
  
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sciencedirect.com/science/article/pii/S155041312400192X
May 2024
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

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1. scibot 07 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.006
  
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sciencedirect.com/science/article/pii/S1074761324002115
Apr 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

Andrographolide regulates H3 histone lactylation by interfering with p300 to alleviate aortic valve calcification

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1. scibot 25 Apr 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1111/bph.16332
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16332
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis

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1. scibot 23 Apr 2024
  
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  RRID:AB_2942013
  
  DOI: 10.1016/j.cell.2024.04.002
  
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sciencedirect.com/science/article/pii/S0092867424003970
Feb 2024
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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113746
  
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sciencedirect.com/science/article/pii/S2211124724000743