370 Matching Annotations
  1. Last 7 days
  2. www.cell.com www.cell.com
    Enhanced and Sustained T Cell Activation in Response to Fluid Shear Stress
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    1. scibot 29 Jun 2024
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      DOI: 10.1016/j.isci.2024.109999

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    cell.com/iscience/abstract/S2589-0042(24)01224-0
  3. Jun 2024
  4. 52.53.155.43 52.53.155.43
    Secretion of WNT7A by UC-MSCs assist in promoting the endometrial epithelial regeneration
    1
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      DOI: 10.1016/j.isci.2024.109888

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    52.53.155.43/cced30d2a74f6a0a443c073a769617b5ff3774c6/1-s2.0-S2589004224011106-main-html.html
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defining cis-regulatory elements and transcription factors that control human cortical interneuron development
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    1. scibot 03 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140214/
  6. May 2024
  7. www.embopress.org www.embopress.org
    Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function | EMBO Molecular Medicine
    1
    1. scibot 31 May 2024
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      DOI: 10.1038/s44321-024-00073-7

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    embopress.org/doi/full/10.1038/s44321-024-00073-7
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    FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation
    1
    1. scibot 31 May 2024
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    sciencedirect.com/science/article/pii/S1534580724003241
  9. www.embopress.org www.embopress.org
    Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function
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    embopress.org/doi/10.1038/s44321-024-00073-7
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    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
    1
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    sciencedirect.com/science/article/pii/S1534580724002995
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    CRACD loss induces neuroendocrine cell plasticity of lung adenocarcinoma
    1
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    sciencedirect.com/science/article/pii/S2211124724006144
  12. 52.53.155.43 52.53.155.43
    mcr-23-0478-html.html
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      DOI: 10.1158/1541-7786.mcr-23-0478

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  13. dx.doi.org dx.doi.org
    An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers
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    1. scibot 22 May 2024
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      DOI: 10.1210/clinem/dgae114

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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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      DOI: 10.1158/1078-0432.CCR-22-2854

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060649/
  15. Apr 2024
  16. www.sciencedirect.com www.sciencedirect.com
    BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
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    1. scibot 30 Apr 2024
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    sciencedirect.com/science/article/pii/S221112472400490X
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities
    1
    1. scibot 30 Apr 2024
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      DOI: 10.3390/biom14040468

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    ncbi.nlm.nih.gov/pmc/articles/PMC11048097/
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    1. scibot 26 Apr 2024
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    sciencedirect.com/science/article/pii/S2666379124001927
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    DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice
    2
    1. scibot 24 Apr 2024
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    sciencedirect.com/science/article/pii/S1534580724002272
  20. 52.53.155.43 52.53.155.43
    mcr-23-0478-html.html
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    The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
    1
    1. scibot 16 Apr 2024
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      DOI: 10.1016/j.bcp.2024.116205

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    sciencedirect.com/science/article/pii/S0006295224001886
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    Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.neuron.2024.03.011

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    sciencedirect.com/science/article/pii/S089662732400165X
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.018

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    sciencedirect.com/science/article/pii/S1534580724001837
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1016/j.isci.2024.109487

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    ncbi.nlm.nih.gov/pmc/articles/PMC10973142/
  25. www.sciencedirect.com www.sciencedirect.com
    Protocol to encapsulate cerebral organoids with alginate hydrogel shell to induce volumetric compression
    1
    1. scibot 02 Apr 2024
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      DOI: 10.1016/j.xpro.2024.102952

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    sciencedirect.com/science/article/pii/S2666166724001175
  26. Mar 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Machine learning unveils immune-related signature in multicenter glioma studies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10946333/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TLR2 regulates hair follicle cycle and regeneration via BMP signaling
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      DOI: 10.7554/eLife.89335

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    ncbi.nlm.nih.gov/pmc/articles/PMC10939499/
  29. www.sciencedirect.com www.sciencedirect.com
    One-step rapid tracking and isolation of senescent cells in cellular systems, tissues, or animal models via GLF16
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    sciencedirect.com/science/article/pii/S2666166724000947
  30. www.sciencedirect.com www.sciencedirect.com
    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
    2
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      DOI: 10.1016/j.xcrm.2024.101461

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    sciencedirect.com/science/article/pii/S2666379124001058
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    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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    sciencedirect.com/science/article/pii/S1535610824000552
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    Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
    2
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    sciencedirect.com/science/article/pii/S1534580723006573
  33. Feb 2024
  34. www.cell.com www.cell.com
    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
  35. www.sciencedirect.com www.sciencedirect.com
    Sphingolipid metabolism controls mammalian heart regeneration
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    sciencedirect.com/science/article/pii/S1550413124000172
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10847737/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments
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    ncbi.nlm.nih.gov/pmc/articles/PMC10849765/
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    An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer
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    sciencedirect.com/science/article/pii/S266637912400034X
  39. www.sciencedirect.com www.sciencedirect.com
    Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice
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    sciencedirect.com/science/article/pii/S2589004224001354
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice
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      DOI: 10.1016/j.isci.2023.108706

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    ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    circCD2AP promotes epithelial mesenchymal transition and stemness in bladder cancer by regulating FOXQ1/USP21 axis
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      DOI: 10.1016/j.isci.2023.108447

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    ncbi.nlm.nih.gov/pmc/articles/PMC10827552/
  42. Jan 2024
  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Promising New Model: Establishment of Patient-Derived Organoid Models Covering HPV-Related Cervical Pre-Cancerous Lesions and Their Cancers
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      DOI: 10.1002/advs.202302340

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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis
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    Differential contribution of TrkB and p75NTR to BDNF-dependent self-renewal, proliferation, and differentiation of adult neural stem cells
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    Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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    AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis
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    Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy
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  56. Nov 2023
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    Preclinical Long-Term Safety of Intraspinal Transplantation of Human Dorsal Spinal GABA Neural Progenitor Cells
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    Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.
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    Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts
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    TGFB1 induces fetal reprogramming and enhances intestinal regeneration
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  61. Oct 2023
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    Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
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    SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models
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    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid maturation and does not impede growth
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    3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer
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    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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    Doxorubicin-induced senescence promotes resistance to cell death by modulating genes associated with apoptotic and necrotic pathways in prostate cancer DU145 CD133+/CD44+ cells
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    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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  72. Sep 2023
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    Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
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    LSR targets YAP to modulate intestinal Paneth cell differentiation
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
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  84. Jul 2023
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    Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells
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    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
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  89. Jun 2023
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation
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    Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
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    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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    A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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    Embryogenic stem cell-derived intestinal crypt fission directs de novo crypt genesis
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    The mitochondrial UPR regulator ATF5 promotes intestinal barrier function via control of the satiety response
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    Staphylococcus aureus extracellular adherence protein (Eap) reduces immune cell phenotype in developing but not in established atherosclerotic lesions
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer
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    Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex
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    Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice
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    FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer
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    The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques
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  149. Oct 2022
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    Follicle stimulating hormone glycosylation variants distinctly modulate pre-antral follicle growth and survival
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    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
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    Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
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  153. Sep 2022
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    Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
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    Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
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    Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
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    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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  158. Aug 2022
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    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
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    Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
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    Alterations of serine racemase expression determine proliferation and differentiation of neuroblastoma cells
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    Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity
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  164. Jul 2022
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    Gender-based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum-fermented rice bran diet against inflammation-associated colon tumorigenesis
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    Protocol to photoactivate adipose-derived stem cell differentiation using a tightly-focused femtosecond laser
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    Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
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  168. Jun 2022
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    GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis
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    Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism
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  173. May 2022
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    Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors
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    Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
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    EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures
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    p57Kip2 imposes the reserve stem cell state of gastric chief cells
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  178. Apr 2022
  179. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Downregulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats
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    GH action in prostate cancer cells promotes proliferation limits apoptosis and regulates cancer-related gene expression
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    Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells
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      DOI: 10.1093/carcin/bgac032

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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
    1
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BARS Influences Neuronal Development by Regulation of Post-Golgi Trafficking
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      DOI: 10.3390/cells11081320

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    ncbi.nlm.nih.gov/pmc/articles/PMC9026897/
  184. www.nature.com www.nature.com
    Identifying a confused cell identity for esophageal squamous cell carcinoma
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      DOI: 10.1038/s41392-022-00946-8

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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer’s Disease
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  186. www.sciencedirect.com www.sciencedirect.com
    Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease
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  187. www.sciencedirect.com www.sciencedirect.com
    Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma
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  188. Mar 2022
  189. www.sciencedirect.com www.sciencedirect.com
    NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dormant Nfatc1 reporter-marked basal stem/progenitor cells contribute to mammary lobuloalveoli formation
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  191. www.sciencedirect.com www.sciencedirect.com
    Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endothelial cells promote the proliferation and migration of Schwann cells
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  193. www.sciencedirect.com www.sciencedirect.com
    Stem cell differentiation with consistent lineage commitment induced by a flash of ultrafast-laser activation in vitro and in vivo
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    Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
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  195. Feb 2022
  196. www.sciencedirect.com www.sciencedirect.com
    An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer
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  197. www.embopress.org www.embopress.org
    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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  198. www.sciencedirect.com www.sciencedirect.com
    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury
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  200. www.sciencedirect.com www.sciencedirect.com
    Development of human alveolar epithelial cell models to study distal lung biology and disease
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    Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
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  202. www.sciencedirect.com www.sciencedirect.com
    Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers
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  203. Jan 2022
  204. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36
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      DOI: 10.1096/fj.202101034R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202101034R
  205. www.sciencedirect.com www.sciencedirect.com
    Limb development genes underlie variation in human fingerprint patterns
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    sciencedirect.com/science/article/pii/S009286742101446X
  206. Dec 2021
  207. www.sciencedirect.com www.sciencedirect.com
    PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer
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    sciencedirect.com/science/article/pii/S2211124721016235
  208. www.sciencedirect.com www.sciencedirect.com
    AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells
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    sciencedirect.com/science/article/pii/S2589004221015406
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    Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence
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    sciencedirect.com/science/article/pii/S2589004221015285
  210. academic.oup.com academic.oup.com
    Regulation of AKT signaling in mouse uterus
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      DOI: 10.1210/endocr/bqab233

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    academic.oup.com/endo/article/163/1/bqab233/6430242
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Isoform-specific roles of prolyl hydroxylases in the regulation of pancreatic β-cell function
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia
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  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity
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  214. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
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    Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer
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  216. Nov 2021
  217. www.sciencedirect.com www.sciencedirect.com
    Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice
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  218. www.sciencedirect.com www.sciencedirect.com
    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    Efferocytosis induces macrophage proliferation to help resolve tissue injury
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  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
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      DOI: 10.7554/eLife.71596

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  221. Oct 2021
  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase
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