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    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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    BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
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    Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities
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    Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
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    DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice
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    mcr-23-0478-html.html
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    The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice
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    Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    Protocol to encapsulate cerebral organoids with alginate hydrogel shell to induce volumetric compression
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    Machine learning unveils immune-related signature in multicenter glioma studies
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    TLR2 regulates hair follicle cycle and regeneration via BMP signaling
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    One-step rapid tracking and isolation of senescent cells in cellular systems, tissues, or animal models via GLF16
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    PRMT1 promotes pancreatic cancer development and resistance to chemotherapy
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    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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    Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
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    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    Sphingolipid metabolism controls mammalian heart regeneration
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    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments
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    An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer
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    Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice
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    Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice
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    circCD2AP promotes epithelial mesenchymal transition and stemness in bladder cancer by regulating FOXQ1/USP21 axis
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  30. Jan 2024
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    A Promising New Model: Establishment of Patient-Derived Organoid Models Covering HPV-Related Cervical Pre-Cancerous Lesions and Their Cancers
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis
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    Human conjunctiva organoids to study ocular surface homeostasis and disease
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    Differential contribution of TrkB and p75NTR to BDNF-dependent self-renewal, proliferation, and differentiation of adult neural stem cells
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    Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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    AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis
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  39. Dec 2023
  40. dx.doi.org dx.doi.org
    Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy
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  44. Nov 2023
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    Preclinical Long-Term Safety of Intraspinal Transplantation of Human Dorsal Spinal GABA Neural Progenitor Cells
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    Microbial-dependent recruitment of immature myeloid cells promotes intestinal regeneration.
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    Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts
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    TGFB1 induces fetal reprogramming and enhances intestinal regeneration
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  49. Oct 2023
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    Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
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    SIRT1 is an actionable target to restore p53 function in HPV-associated cancer therapy
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    Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models
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    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid maturation and does not impede growth
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    3D-printed scaffold harboring copper ions combined with near-infrared irradiation for local therapy of cancer
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    A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
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    Doxorubicin-induced senescence promotes resistance to cell death by modulating genes associated with apoptotic and necrotic pathways in prostate cancer DU145 CD133+/CD44+ cells
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    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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    Piezo1 activates noncanonical EGFR endocytosis and signaling
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  60. Sep 2023
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    Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition
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    LSR targets YAP to modulate intestinal Paneth cell differentiation
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    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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  65. Aug 2023
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    Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment
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    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice
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    Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+
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  72. Jul 2023
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    Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells
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    MAP4Ks inhibition promotes retinal neuron regeneration from Müller glia in adult mice
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    Derivation of CD8+ T-cell Infiltration Potentiators in Non-Small Cell Lung Cancer Through Tumor Microenvironment Analysis
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    Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
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  77. Jun 2023
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets
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    Mammary Tumor Growth and Proliferation Are Dependent on Growth Hormone in Female SV40 C3(1) T-Antigen Mice
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    Spatially resolved multi-omics single-cell analyses inform mechanisms of immune-dysfunction in pancreatic cancer
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    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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  85. May 2023
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    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    Zhx2 maintains islet β cell mass and function by transcriptionally regulating Pax6
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    Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: Implications for surgical and clinical outcomes
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    Multimodal characterization of murine gastruloid development
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    Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells
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    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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    A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression
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    Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer
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    The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques
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  137. Oct 2022
  138. academic.oup.com academic.oup.com
    Follicle stimulating hormone glycosylation variants distinctly modulate pre-antral follicle growth and survival
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  139. elifesciences.org elifesciences.org
    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
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    Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation
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  141. Sep 2022
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    Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10
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    Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer
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    A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
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  146. Aug 2022
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    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system
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    Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression
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  150. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Alterations of serine racemase expression determine proliferation and differentiation of neuroblastoma cells
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    Multiregional single-cell proteogenomic analysis of ccRCC reveals cytokine drivers of intratumor spatial heterogeneity
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  152. Jul 2022
  153. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Gender-based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum-fermented rice bran diet against inflammation-associated colon tumorigenesis
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    Protocol to photoactivate adipose-derived stem cell differentiation using a tightly-focused femtosecond laser
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    Potassium channel Kir4.1 regulates oligodendrocyte differentiation via intracellular pH regulation
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  156. Jun 2022
  157. 52.53.155.43 52.53.155.43
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    GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis
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    Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism
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    Diploid hepatocytes drive physiological liver renewal in adult humans
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  161. May 2022
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    Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors
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    Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15
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    EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures
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    p57Kip2 imposes the reserve stem cell state of gastric chief cells
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  166. Apr 2022
  167. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Downregulation of microRNA-124-3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats
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  168. academic.oup.com academic.oup.com
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    Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcription factors AP-2α and AP-2β regulate distinct segments of the distal nephron in the mammalian kidney
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  172. www.nature.com www.nature.com
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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease
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    Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma
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  176. Mar 2022
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    NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dormant Nfatc1 reporter-marked basal stem/progenitor cells contribute to mammary lobuloalveoli formation
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    Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity
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    Endothelial cells promote the proliferation and migration of Schwann cells
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    Stem cell differentiation with consistent lineage commitment induced by a flash of ultrafast-laser activation in vitro and in vivo
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    Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
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  183. Feb 2022
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    An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer
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    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury
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    Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
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    Histone chaperone FACT complex coordinates with HIF to mediate an expeditious transcription program to adapt to poorly oxygenated cancers
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  191. Jan 2022
  192. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Eukaryotic elongation factor 2 kinase regulates foam cell formation via translation of CD36
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    Limb development genes underlie variation in human fingerprint patterns
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  194. Dec 2021
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    PAK5 promotes RNA helicase DDX5 sumoylation and miRNA-10b processing in a kinase-dependent manner in breast cancer
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    AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells
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    Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence
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    A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity
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    Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment
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    Redox-sensitive cyclophilin A elicits chemoresistance through realigning cellular oxidative status in colorectal cancer
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  204. Nov 2021
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    Identification of a gut microbiota member that ameliorates DSS-induced colitis in intestinal barrier enhanced Dusp6-deficient mice
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
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  209. Oct 2021
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    Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase
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    miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation
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    Nicotinamide riboside relieves paclitaxel-induced peripheral neuropathy and enhances suppression of tumor growth in tumor-bearing rats
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  213. Sep 2021
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    Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis
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    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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    Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave
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    Complement Factor B Mediates Ocular Angiogenesis through Regulating the VEGF Signaling Pathway
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    Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity
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  219. Aug 2021
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    In vivo monitoring of the therapeutic efficacy of a CXCR1/2 inhibitor with 18F-FDG PET/CT imaging in experimental head and neck carcinoma: A feasibility study
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    Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding
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