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CDT1 acts with the replisome to remodel replication forks

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1. scibot 20 Aug 2026
  
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  RRID:AB_302873
  
  DOI: 10.1126/sciadv.aee6914
  
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science.org/doi/10.1126/sciadv.aee6914
Jul 2026
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RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity

1
1. scibot 21 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.036
  
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sciencedirect.com/science/article/pii/S1097276526004259
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

SLX4IP limits replication stress globally and at ALT telomeres

1
1. scibot 18 Jun 2026
  
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  DOI: 10.1038/s44318-026-00790-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13269807/
Mar 2026
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Ski2-like helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

1
1. scibot 06 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117051
  
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sciencedirect.com/science/article/pii/S2211124726001294
Jan 2026
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N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to control HPV replication

1
1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116828
  
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sciencedirect.com/science/article/pii/S2211124725016006
Jul 2025
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TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

1
1. scibot 03 Jul 2025
  
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  AB_302873
  
  DOI: 10.1016/j.molcel.2025.06.009
  
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sciencedirect.com/science/article/pii/S109727652500509X
May 2025
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BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.010
  
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sciencedirect.com/science/article/pii/S1097276525004150
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy

1
1. scibot 20 Mar 2025
  
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  DOI: 10.1038/s41598-025-92697-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11906863/
Dec 2024
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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

1
1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.034
  
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sciencedirect.com/science/article/pii/S1097276524009894
academic.oup.com academic.oup.com

CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation

1
1. scibot 13 Dec 2024
  
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  AB_2175
  
  DOI: 10.1093/nar/gkae1068
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1068/7903364
Sep 2024
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

1
1. scibot 12 Sep 2024
  
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  AB_302873
  
  DOI: 10.1016/j.cell.2024.08.020
  
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sciencedirect.com/science/article/pii/S0092867424009115
Aug 2024
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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

1
1. scibot 02 Aug 2024
  
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  DOI: 10.1016/j.molcel.2021.01.004
  
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sciencedirect.com/science/article/pii/S1097276521000046
Jul 2024
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Identification of the main barriers to Ku accumulation in chromatin

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1. scibot 30 Jul 2024
  
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  AB_302873
  
  DOI: 10.1016/j.celrep.2024.114538
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11411529/
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FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition

1
1. scibot 17 Jul 2024
  
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  AB_302873
  
  DOI: 10.1016/j.celrep.2024.114464
  
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sciencedirect.com/science/article/pii/S2211124724007939
May 2024
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Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

1
1. scibot 16 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114205
  
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sciencedirect.com/science/article/pii/S2211124724005333
Apr 2024
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RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

2
1. scibot 19 Apr 2024
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2024.114116
  
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2. scibot 19 Apr 2024
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2024.114116
  
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sciencedirect.com/science/article/pii/S2211124724004443
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

2
1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114064
  
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2. scibot 09 Apr 2024
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2024.114064
  
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sciencedirect.com/science/article/pii/S2211124724003929
Feb 2024
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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

1
1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.02.002
  
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sciencedirect.com/science/article/pii/S1097276524000984
52.53.155.43 52.53.155.43

53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

1
1. scibot 22 Feb 2024
  
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  RRID:AB_302873
  
  DOI: 10.1101/2023.09.27.559698
  
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52.53.155.43/9b07aa3872d935df1f2ff4d73fc96f76996bcf22/2023.09.27.559698v1.full-html.html
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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

1
1. scibot 13 Feb 2024
  
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  AB_302873
  
  DOI: 10.1016/j.celrep.2024.113778
  
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sciencedirect.com/science/article/pii/S2211124724001062
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

1
1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.isci.2024.108925
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
Jan 2024
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EXO1 protects BRCA1-deficient cells against toxic DNA lesions

1
1. scibot 25 Jan 2024
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.molcel.2023.12.039
  
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sciencedirect.com/science/article/pii/S1097276523010857
Dec 2023
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53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

1
1. scibot 02 Dec 2023
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2023.113412
  
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sciencedirect.com/science/article/pii/S2211124723014249
Oct 2023
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Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability

1
1. scibot 13 Oct 2023
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.cell.2023.09.008
  
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sciencedirect.com/science/article/abs/pii/S0092867423010309
Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

1
1. scibot 12 Sep 2023
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2023.113113
  
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sciencedirect.com/science/article/pii/S2211124723011245
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress

2
1. scibot 26 Aug 2023
  
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  AB_302873
  
  DOI: 10.1158/2767-9764.CRC-23-0268
  
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2. scibot 26 Aug 2023
  
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  AB_302873
  
  DOI: 10.1158/2767-9764.CRC-23-0268
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
52.53.155.43 52.53.155.43

crc-23-0268-html.html

1
1. scibot 11 Aug 2023
  
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  AB_302873
  
  DOI: 10.1158/2767-9764.crc-23-0268
  
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52.53.155.43/385511300daa3e14cefdae67d8cec9d074c7314f/crc-23-0268-html.html
Jul 2023
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.025
  
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sciencedirect.com/science/article/pii/S1097276523004720
Jun 2023
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Detection of endogenous translesion DNA synthesis in single mammalian cells

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1. scibot 22 Jun 2023
  
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  DOI: 10.1016/j.crmeth.2023.100501
  
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sciencedirect.com/science/article/pii/S2667237523001303
Apr 2023
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ERCC6L2 mitigates replication stress and promotes centromere stability

1
1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112329
  
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sciencedirect.com/science/article/pii/S2211124723003406
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells

1
1. scibot 04 Apr 2023
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.isci.2023.106405
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
Mar 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX deficient cells

1
1. scibot 30 Mar 2023
  
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  DOI: 10.1016/j.isci.2023.106405
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10066556/
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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination

1
1. scibot 28 Mar 2023
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2023.112296
  
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sciencedirect.com/science/article/pii/S2211124723003078
Feb 2023
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RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1

1
1. scibot 02 Feb 2023
  
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  RRID:AB_302873
  
  DOI: 10.1016/j.celrep.2023.112032
  
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GEN1 promotes common fragile site expression

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The ADP-ribose hydrolase NUDT5 is important for DNA repair

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Quantification of protein enrichment at site-specific DNA double-strand breaks by chromatin immunoprecipitation in cultured human cells

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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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Guiding ATR and PARP inhibitor combinationswith chemogenomic screens

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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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BMI-1 regulates DNA end resection and homologous recombination repair

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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

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RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair

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Untitled document

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Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe

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The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures

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Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38

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Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

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ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

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May 2021
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Homology-directed repair protects the replicating genome from metabolic assaults

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ER-directed TREX1 limits cGAS activation at micronuclei

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Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38

1
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Jan 2021
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DCAF14 promotes stalled fork stability to maintain genome integrity

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RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

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MutSβ Stimulates Holliday Junction Resolution by the SMX Complex

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Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

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Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle

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Jan 2020
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RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

1
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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

1
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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

1
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  DOI: 10.1016/j.molcel.2019.10.008
  
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Untitled document

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Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

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  DOI: 10.1016/j.celrep.2019.05.002
  
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  DOI: 10.1016/j.molcel.2019.04.024
  
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Untitled document

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  DOI: 10.1016/j.molcel.2019.02.014
  
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CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

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Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

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POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication

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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

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Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors

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Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling

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RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks

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RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

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RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health

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1. scibot 08 Nov 2017
  
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