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H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions

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  DOI: 10.1016/j.celrep.2026.117639
  
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sciencedirect.com/science/article/pii/S2211124726007175
Apr 2026
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MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

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  DOI: 10.1016/j.molcel.2026.03.032
  
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sciencedirect.com/science/article/pii/S109727652600208X
Feb 2026
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Cytoplasmic mRNA decay by the antiviral nuclease RNase L promotes transcriptional repression

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1. scibot 27 Feb 2026
  
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  DOI: 10.1016/j.celrep.2026.117028
  
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sciencedirect.com/science/article/pii/S2211124726001063
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RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity

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1. scibot 24 Feb 2026
  
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  DOI: 10.1126/sciadv.aea5932
  
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science.org/doi/10.1126/sciadv.aea5932
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RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity

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pmc.ncbi.nlm.nih.gov/articles/PMC12922753/
Jan 2026
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MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids

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  DOI: 10.1016/j.cell.2025.12.019
  
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sciencedirect.com/science/article/pii/S0092867425014321
Dec 2025
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SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes

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1. scibot 23 Dec 2025
  
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  DOI: 10.1126/sciadv.adt7982
  
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SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes

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1. scibot 20 Dec 2025
  
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  DOI: 10.1126/sciadv.adt7982
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12710720/
Nov 2025
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Off-pore nucleoporin sPOM121 transcriptionally propels β-Catenin driven tumor progression and immune escape in prostate cancer

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1. scibot 24 Nov 2025
  
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  DOI: 10.1158/2159-8290.CD-25-0629
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12580793/
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Debranching enzyme DBR1-mediated lariat RNA turnover requires ALBA proteins in Arabidopsis

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  DOI: 10.1016/j.molcel.2025.10.021
  
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sciencedirect.com/science/article/pii/S1097276525008627
Oct 2025
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Dcr1 senses R-loops for RNAPII termination at sites of replication stress and repair pathway choice

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1. scibot 29 Oct 2025
  
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  DOI: 10.1016/j.molcel.2025.10.004
  
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Transcription-replication conflict resolution by nuclear RNA interference

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1. scibot 29 Oct 2025
  
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  DOI: 10.1016/j.molcel.2025.10.003
  
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The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress

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1. scibot 11 Oct 2025
  
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  DOI: 10.1038/s44319-025-00550-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12508481/
Aug 2025
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Promoter- and enhancer-dependent cohesin loading initiates chromosome looping to fold Tcrb loci for long-range recombination

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116133
  
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sciencedirect.com/science/article/pii/S2211124725009040
Jul 2025
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The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

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1. scibot 23 Jul 2025
  
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  DOI: 10.7554/eLife.41444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6447362/
Jun 2025
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Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112778
  
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sciencedirect.com/science/article/pii/S2589004225010399
May 2025
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Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.molcel.2025.05.006
  
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sciencedirect.com/science/article/pii/S1097276525004113
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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
Apr 2025
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1-s2.0-S2589004225007187-main-html.html

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Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

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Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer

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  DOI: 10.1158/1535-7163.MCT-24-0785
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11962390/
Mar 2025
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Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity

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pmc.ncbi.nlm.nih.gov/articles/PMC11906161/
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Transcription elongation factor ELOF1 is required for efficient somatic hypermutation and class switch recombination

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  DOI: 10.1016/j.molcel.2025.02.007
  
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Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II

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Jan 2025
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Deciphering transcription activity of mammalian early embryos unveils on/off of zygotic genome activation by protein translation/degradation

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  DOI: 10.1016/j.celrep.2024.115215
  
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sciencedirect.com/science/article/pii/S2211124724015663
Dec 2024
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TBP bookmarks and preserves neural stem cell fate memory by orchestrating local chromatin architecture

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  DOI: 10.1016/j.molcel.2024.11.019
  
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Nov 2024
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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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  DOI: 10.1016/j.cell.2024.10.018
  
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sciencedirect.com/science/article/pii/S0092867424012005
Aug 2024
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Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

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1. scibot 26 Aug 2024
  
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  DOI: 10.7554/eLife.94407
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11343564/
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Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation

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Jul 2024
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Mechanomemory of nucleoplasm and RNA polymerase II after chromatin stretching by a microinjected magnetic nanoparticle force

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DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal

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  DOI: 10.1016/j.celrep.2024.114420
  
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Jun 2024
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DNMT3B splicing dysregulation mediated by SMCHD1 loss contributes to DUX4 overexpression and FSHD pathogenesis

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  DOI: 10.1126/sciadv.adn7732
  
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DNMT3B splicing dysregulation mediated by SMCHD1 loss contributes to DUX4 overexpression and FSHD pathogenesis

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  DOI: 10.1126/sciadv.adn7732
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11135424/
Apr 2024
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DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability

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  DOI: 10.1016/j.molcel.2024.03.006
  
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sciencedirect.com/science/article/pii/S1097276524001886
Mar 2024
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RNAP II antagonizes mitotic chromatin folding and chromosome segregation by condensin

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  DOI: 10.1016/j.celrep.2024.113901
  
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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

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Collisions of RNA polymerases behind the replication fork promote alternative RNA splicing in newly replicated chromatin

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Asymmetrical nucleosomal DNA signatures regulate transcriptional directionality

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A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV-infected cells

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Targeted perturbation of signaling-driven condensates

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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

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Human histone H1 variants impact splicing outcome by controlling RNA polymerase II elongation

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DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres

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PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection

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EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release

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MDC1 maintains active elongation complexes of RNA polymerase II

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Distinct patterns of RNA polymerase II and transcriptional elongation characterize mammalian genome activation

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SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy

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Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization

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Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer

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Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures

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Confined migration induces heterochromatin formation and alters chromatin accessibility

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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

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The PAF1 complex promotes 3′ processing of pervasive transcripts

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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

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Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

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Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration

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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

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C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing

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The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory

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The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output

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C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing

1
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A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory

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Nucleome Dynamics during Retinal Development

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A global chromatin compaction pathway that represses germline gene expression during starvation

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m6A RNA methylation regulates promoter- proximal pausing of RNA polymerase II

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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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Nascent RNA antagonizes the interaction of a set of regulatory proteins with chromatin

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DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity

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Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

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Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

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Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

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Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

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BET inhibition by JQ1 produces divergent transcriptional regulation of SOCS genes in adipocytes

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  DOI: 10.1210/endocr/bqz034
  
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Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans

1
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  DOI: 10.1534/genetics.120.303292
  
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

1
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Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair

1
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Cohesin Removal Reprograms Gene Expression upon Mitotic Entry

1
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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

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Cohesin-Dependent and -Independent Mechanisms Mediate Chromosomal Contacts between Promoters and Enhancers

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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

1
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H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome Assembly

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Nucleome Dynamics during Retinal Development

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CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

1
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Hippocampal stimulation promotes intracellular Tip60 dynamics with concomitant genome reorganization and synaptic gene activation

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Untitled document

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Untitled document

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  DOI: 10.1016/j.molcel.2018.11.036
  
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Untitled document

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Untitled document

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Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

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Tracing MYC Expression for Small Molecule Discovery

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Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting

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Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

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The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

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A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

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SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation

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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

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Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

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The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

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Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States

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Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells

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Evolutionarily Conserved Principles Predict 3D Chromatin Organization

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GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK

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Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle

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The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

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DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition

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Transcriptional Elongation of HSV Immediate Early Genes by the Super Elongation Complex Drives Lytic Infection and Reactivation from Latency

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Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation

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Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

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