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Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Ptip and the Trr-COMPASS-like Complex Regulate Cardiac Progenitor Cell Division in the Drosophila Embryonic Heart Tube

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1. scibot 27 Aug 2025
  
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  DOI: 10.3390/ijms26167954
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12386242/
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Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer

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1. scibot 27 Aug 2025
  
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  DOI: 10.1126/sciadv.adt1798
  
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science.org/doi/10.1126/sciadv.adt1798
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Enhancer remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm

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  DOI: 10.1016/j.devcel.2025.07.020
  
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sciencedirect.com/science/article/pii/S1534580725004964
Jul 2025
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β-catenin functions as a molecular adapter for disordered cBAF interactions

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.026
  
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sciencedirect.com/science/article/pii/S1097276525005763
Jun 2025
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  DOI: 10.1158/2159-8290.cd-24-1904
  
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52.53.155.43/fedd6ccff8c0b6494dbe8595a0c800e33e0860f7/PDF-html.html
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Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma

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1. scibot 11 Jun 2025
  
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  DOI: 10.7554/eLife.105339.1
  
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elifesciences.org/reviewed-preprints/105339v1
May 2025
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Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115746
  
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sciencedirect.com/science/article/pii/S2211124725005170
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Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115601
  
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sciencedirect.com/science/article/pii/S2211124725003729
Mar 2025
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Amplified dosage of the NKX2-1 lineage transcription factor controls its oncogenic role in lung adenocarcinoma

1
1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.03.001
  
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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1097276525001479
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SRBD1, a highly conserved gene required for chromosome individualization

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115443
  
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sciencedirect.com/science/article/pii/S2211124725002141
Feb 2025
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Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/endocr/bqae123
  
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dx.doi.org/10.1210/endocr/bqae123
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Microglial plasticity governed by state-specific enhancer landscapes

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1. scibot 07 Feb 2025
  
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  DOI: 10.1101/2025.01.30.635595
  
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biorxiv.org/content/10.1101/2025.01.30.635595v1
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KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115272
  
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sciencedirect.com/science/article/pii/S2211124725000439
Jan 2025
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Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex

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1. scibot 16 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115213
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11864812/
Dec 2024
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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer

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1. scibot 24 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115089
  
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sciencedirect.com/science/article/pii/S2211124724014402
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EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.devcel.2024.11.014
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00696-8
Sep 2024
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Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110854
  
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sciencedirect.com/science/article/pii/S2589004224020790
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification

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1. scibot 23 Aug 2024
  
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  DOI: 10.7554/eLife.96216
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11333042/
Jul 2024
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A CPF-like phosphatase module links transcription termination to chromatin silencing

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1. scibot 26 Jul 2024
  
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  DOI: 10.1016/j.molcel.2024.05.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7616277/
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YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114456
  
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cell.com/cell-reports/abstract/S2211-1247(24)00785-X
Jun 2024
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Proximal termination generates a transcriptional state that determines the rate of establishment of Polycomb silencing

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1. scibot 21 Jun 2024
  
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  DOI: 10.1016/j.molcel.2024.05.014
  
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CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex

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1. scibot 13 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114227
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11163479/
May 2024
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A chromatin code for limb segment identity in axolotl limb regeneration

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.devcel.2024.05.002
  
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A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.007
  
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sciencedirect.com/science/article/pii/S1074761324002127
Apr 2024
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The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other’s chromatin binding dynamics and transcription in vivo

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  DOI: 10.1016/j.devcel.2024.04.006
  
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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

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1. scibot 18 Apr 2024
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction

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  DOI: 10.1016/j.immuni.2024.03.018
  
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sciencedirect.com/science/article/pii/S1074761324001390
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H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation

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  DOI: 10.1016/j.molcel.2024.02.030
  
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SAFB restricts contact domain boundaries associated with L1 chimeric transcription

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  DOI: 10.1016/j.molcel.2024.03.021
  
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sciencedirect.com/science/article/pii/S1097276524002314
Mar 2024
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Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma

2
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  DOI: 10.1016/j.xcrm.2024.101468
  
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  DOI: 10.1016/j.xcrm.2024.101468
  
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sciencedirect.com/science/article/pii/S2666379124001149
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Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region

2
1. scibot 15 Mar 2024
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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  DOI: 10.1021/acs.jmedchem.3c01549
  
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The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA

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1. scibot 14 Mar 2024
  
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  DOI: 10.1016/j.devcel.2024.02.008
  
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  DOI: 10.1016/j.devcel.2024.02.008
  
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sciencedirect.com/science/article/pii/S1534580724001072
Feb 2024
52.53.155.43 52.53.155.43

bvae029-html.html

1
1. scibot 15 Feb 2024
  
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  DOI: 10.1210/jendso/bvae029
  
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FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor

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PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression

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XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells

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Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage

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Super-enhancers include classical enhancers and facilitators to fully activate gene expression

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Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF

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RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size

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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation

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PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly

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Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells

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Perturbations in 3D genome organization can promote acquired drug resistance

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Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the PLIN2 promoter

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Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution

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SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin

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Aug 2023
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Srd5a1 is Differentially Regulated and Methylated During Prepubertal Development in the Ovary and Hypothalamus

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Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

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Histone variants shape chromatin states in Arabidopsis

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The default and directed pathways of hepatoblast differentiation involve distinct epigenomic mechanisms

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SETD7 promotes lateral plate mesoderm formation by modulating the Wnt/β-catenin signaling pathway

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Chemical-induced epigenome resetting for regeneration program activation in human cells

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Mechanical pressure-induced dedifferentiation of myofibroblasts inhibits scarring via SMYD3/ITGBL1 signaling

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SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin

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  DOI: 10.21203/rs.3.rs-2721176/v1
  
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Apr 2023
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NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

1
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Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis

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NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

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Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

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Regulation of human trophoblast gene expression by endogenous retroviruses

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Mar 2023
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Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

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Aryl hydrocarbon receptor activity downstream of IL-10 signaling is required to promote regulatory functions in human dendritic cells

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Dec 2022
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Hypoxia induces transgenerational epigenetic inheritance of small RNAs

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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

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SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy

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Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

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Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters

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Sep 2022
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Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung

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Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes

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Binary outcomes of enhancer activity underlie stable random monoallelic expression

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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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MUC1-C Dictates JUN and BAF-mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

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MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation

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A cell-sorting-based protocol for cell cycle small-scale ChIP sequencing

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Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

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Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing

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Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells

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In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

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SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

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Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos

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TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

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Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine

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Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma

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Collective regulation of chromatin modifications predicts replication timing during cell cycle

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MLL3 is a de novo cause of endocrine therapy resistance

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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

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KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2

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Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

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Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

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Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States

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FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

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Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation

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  Rabbit polyclonal anti-H3K4me1
  
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Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

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Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

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A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire

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Untitled document

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Untitled document

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  AB_3
  
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Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy

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Muscle regeneration controlled by a designated DNA dioxygenase

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May 2021
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Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

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Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication

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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML

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An Activity-Mediated Transition in Transcription in Early Postnatal Neurons

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Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells

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Folding Keratin Gene Clusters during Skin Regional Specification

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Comprehensive Chromosome End Remodeling during Programmed DNA Elimination

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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23

1
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A Chromatin Accessibility Atlas of the Developing Human Telencephalon

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Multi-omic profiling of pituitary thyrotropic cells and progenitors

1
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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

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A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

1
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Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

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Feb 2021
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A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation

1
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Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin

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Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

1
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Dec 2020
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Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

1
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Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring

1
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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

1
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Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder

1
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KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

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Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue

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DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State

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H3K4me1 Distribution Predicts Transcription State and Poising at Promoters

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  DOI: 10.3389/fcell.2020.00289
  
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Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers

1
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Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin

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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

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Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

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A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

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A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

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Nucleome Dynamics during Retinal Development

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The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair

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Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

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SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring

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MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State

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Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications

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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes

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LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors

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Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG

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Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice

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Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons

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TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation

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Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4

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Developmental Exposure to Psychostimulant Primes Activity‐dependent Gene Induction in Frontal Cortex

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Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques

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Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia

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The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection

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PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression

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Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance

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Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes

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HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

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Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies

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MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis

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Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency

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The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain

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Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression

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Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

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A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas

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Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress

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Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19

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GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency

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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

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Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation

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MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes

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BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome

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Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis

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