233 Matching Annotations
  1. Last 7 days
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    sciencedirect.com/science/article/pii/S1097276524002259
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    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
  4. Apr 2024
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    14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming
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    sciencedirect.com/science/article/pii/S2211124724003826
  6. Mar 2024
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    C17orf80 binds the mitochondrial genome to promote its replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC10484793/
  8. Feb 2024
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    Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma
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    cell.com/cell-metabolism/abstract/S1550-4131(24)00018-4
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    Histone methylation readers MRG1/2 interact with PIF4 to promote thermomorphogenesis in Arabidopsis
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    sciencedirect.com/science/article/pii/S2211124724000548
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    Asymmetric neurons are necessary for olfactory learning in the Drosophila brain
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  12. Jan 2024
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    ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1
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    sciencedirect.com/science/article/pii/S1534580723006986
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    Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice
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    Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents
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  16. Dec 2023
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    Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
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    sciencedirect.com/science/article/pii/S2666379123005591
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    Prothymosin α accelerates dengue virus-induced thrombocytopenia
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    sciencedirect.com/science/article/pii/S2589004223024999
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    In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
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  20. Nov 2023
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  22. Oct 2023
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    N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation
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    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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  25. Sep 2023
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    RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression
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    sciencedirect.com/science/article/pii/S1097276523006937
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    TOBF1 modulates mouse embryonic stem cell fate through regulating alternative splicing of pluripotency genes
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    sciencedirect.com/science/article/pii/S2211124723011890
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    High temperature inhibits vascular development via the PIF4-miR166-HB15 module in Arabidopsis
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    sciencedirect.com/science/article/pii/S0960982223008345
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    Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells
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    Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement
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    ncbi.nlm.nih.gov/pmc/articles/PMC10484527/
  31. Aug 2023
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    Genome-scale chromatin interaction dynamic measurements for key components of the RNA Pol II general transcription machinery
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  33. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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    Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
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    FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
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    Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila
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  38. Jul 2023
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    A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
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    Transcription factors interact with RNA to regulate genes
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    Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies
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  42. Jun 2023
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    Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
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      DOI: 10.1016/j.stem.2023.05.015

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    Novel MKRN3 Missense Mutations Associated with Central Precocious Puberty Reveal Distinct Effects on Ubiquitination
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      DOI: 10.1210/clinem/dgad151

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  45. May 2023
  46. 52.53.155.43 52.53.155.43
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    Co-transcriptional genome surveillance by HUSH is coupled to termination machinery
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  49. Apr 2023
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    Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex
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    Germline and somatic inactivating FLCN variants in parathyroid cancer and atypical parathyroid tumors
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      DOI: 10.1210/clinem/dgad136

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgad136/7080719
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    APP and Bace1: differential effect of cholesterol enrichment on processing and plasma membrane mobility
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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  54. Mar 2023
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    Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation
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    Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
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  57. Jan 2023
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    CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons
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    mRNA transport, translation, and decay in adult mammalian central nervous system axons
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  60. Dec 2022
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    Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression
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    An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila pVALIUM10 TRiP RNAi lines cause undesired silencing of Gateway-based transgenes
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  65. Nov 2022
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXR2 is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits
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  68. Oct 2022
  69. www.sciencedirect.com www.sciencedirect.com
    BCAT1 redox function maintains mitotic fidelity
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes
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  71. www.nature.com www.nature.com
    Regulation of KDM5C stability and enhancer reprogramming in breast cancer
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  72. Sep 2022
  73. www.sciencedirect.com www.sciencedirect.com
    Lateral axonal modulation is required for stimulus-specific olfactory conditioning in Drosophila
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  74. Aug 2022
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    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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    Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases
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    A modified CUT&RUN-seq technique for qPCR analysis of chromatin-protein interactions
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  78. Jul 2022
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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  80. Jun 2022
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    Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals
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    Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila
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    Tandem immuno-purification of affinity-tagged proteins from mouse testis extracts for MS analysis
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    A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency
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  85. May 2022
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    TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death
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    The Taspase1/Myosin1f-axis regulates filopodia dynamics
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    Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation
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  89. Apr 2022
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    Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation
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  91. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
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    The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
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    ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
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  96. Feb 2022
  97. www.cell.com www.cell.com
    Transcription factor protein interactomes reveal genetic determinants in heart disease
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    FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons
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      DOI: 10.7554/eLife.71892

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    Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing
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    PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II
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  101. Jan 2022
  102. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development
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    Control of mammalian locomotion by ventral spinocerebellar tract neurons
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    The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease
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    WASH interacts with Ku to regulate DNA double-stranded break repair
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  107. Dec 2021
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    Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila
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    A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy
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    Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks
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    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks
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    The Hsp90 cochaperone TTT promotes cotranslational maturation of PIKKs prior to complex assembly
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    NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain
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    CWI pathway participated in vegetative growth and pathogenicity through a downstream effector AflRlm1 in Aspergillus flavus
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  123. Sep 2021
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Generation and characterization of an endogenously tagged SPG11- human iPSC line by CRISPR/Cas9 mediated knock-in
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    Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription
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    The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms
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  137. Jul 2021
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    Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs
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    Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense
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    A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis
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    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo
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    Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
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    Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
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    Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System
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    Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
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    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
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    A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex
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  159. Jun 2021
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    Protocol for determining protein cysteine thiol redox status using western blot analysis
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    Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging
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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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    A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y
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  176. Jan 2021
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    GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats
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    Antagonistic Regulation by CPN60A and CLPC1 of TRXL1 that Regulates MDH Activity Leading to Plant Disease Resistance and Thermotolerance
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    Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling
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    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair
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    The Protein Translocation Defect of MCT8L291R Is Rescued by Sodium Phenylbutyrate
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    Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation
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    The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis
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    SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation
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    Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability
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    Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila
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    Transcriptional profiling aligned with in situ expression image analysis reveals mosaically‐expressed molecular markers for GABA neuron sub‐groups in the ventral tegmental area
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    Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF
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    Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action
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    FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory
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    RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex
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    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo
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    Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation
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    RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice
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    Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
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    Modeling the Biochemical Phenotype of MCT8 Mutations In Vitro: Resolving a Troubling Inconsistency
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    Identification of a Single Pair of Interneurons for Bitter Taste Processing in the Drosophila Brain
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    Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery
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