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Pseudouridine synthase 1-targeted therapy activates antiviral immunity to boost cancer immunotherapy

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116233
  
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sciencedirect.com/science/article/pii/S2211124725010046
Aug 2025
www.tandfonline.com www.tandfonline.com

A preclinical model for the identification of therapeutically active transgenes in local cancer immunotherapy

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1. scibot 21 Aug 2025
  
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  DOI: 10.1080/2162402X.2025.2543620
  
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tandfonline.com/doi/full/10.1080/2162402X.2025.2543620
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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.017
  
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sciencedirect.com/science/article/pii/S1074761325003267
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Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116156
  
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sciencedirect.com/science/article/pii/S2211124725009271
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1-s2.0-S2589004225010338-main-html.html

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1. scibot 12 Aug 2025
  
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  AB_312691
  
  DOI: 10.1016/j.isci.2025.112772
  
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52.53.155.43/8b0897d2d35a8ab9ab351db77e0eeb32b8358112/1-s2.0-S2589004225010338-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Scavenger Receptor CD36 in Tumor-Associated Macrophages Promotes Cancer Progression by Dampening Type I Interferon Signaling

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1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-23-4027
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11788022/
May 2025
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Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy

1
1. scibot 29 May 2025
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.chom.2025.04.022
  
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sciencedirect.com/science/article/pii/S1931312825001556
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Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115679
  
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sciencedirect.com/science/article/pii/S2211124725004504
Feb 2025
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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.chembiol.2025.01.004
  
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sciencedirect.com/science/article/pii/S2451945625000042
Jan 2025
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Postprandial parasympathetic signals promote lung type 2 immunity

1
1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.neuron.2024.12.020
  
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sciencedirect.com/science/article/pii/S089662732400919X
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Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection

1
1. scibot 23 Jan 2025
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.chom.2024.12.017
  
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sciencedirect.com/science/article/pii/S1931312824004840
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Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

1
1. scibot 04 Jan 2025
  
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  DOI: 10.7554/eLife.97654
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11687936/
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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

1
1. scibot 03 Jan 2025
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.celrep.2024.115125
  
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sciencedirect.com/science/article/pii/S2211124724014761
Nov 2024
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A subset of neutrophils activates anti-tumor immunity and inhibits non-small-cell lung cancer progression

1
1. scibot 11 Nov 2024
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.devcel.2024.10.010
  
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sciencedirect.com/science/article/pii/S1534580724006294
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

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1. scibot 07 Nov 2024
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.xcrm.2024.101751
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11513825/
Aug 2024
www.science.org www.science.org

Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease

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1. scibot 18 Aug 2024
  
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  RRID:AB_312691
  
  DOI: 10.1126/sciadv.ado8222
  
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science.org/doi/10.1126/sciadv.ado8222
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Artificial mucus layer formed in response to ROS for the oral treatment of inflammatory bowel disease

1
1. scibot 31 Jul 2024
  
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  RRID:AB_312691
  
  DOI: 10.1126/sciadv.ado8222
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11277472/
May 2024
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Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression

1
1. scibot 30 May 2024
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.immuni.2024.05.004
  
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sciencedirect.com/science/article/pii/S1074761324002553
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PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma

1
1. scibot 17 May 2024
  
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  RRID:AB_312691
  
  DOI: 10.1158/0008-5472.CAN-23-2521
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11094425/
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Time of Day and Circadian Disruption Influence Host Response and Parasite Growth in a Mouse Model of Cerebral Malaria

1
1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109684
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11053314/
aacrjournals.org aacrjournals.org

EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

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1. scibot 19 Apr 2024
  
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  RRID:AB_312691
  
  DOI: 10.1158/2159-8290.CD-23-0434
  
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aacrjournals.org/cancerdiscovery/article/14/3/524/734906/EGFR-Driven-Lung-Adenocarcinomas-Co-opt-Alveolar
Mar 2024
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

2
1. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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2. scibot 13 Mar 2024
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.immuni.2024.02.014
  
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sciencedirect.com/science/article/pii/S1074761324000906
Nov 2023
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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

1
1. scibot 18 Nov 2023
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.isci.2023.108348
  
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sciencedirect.com/science/article/pii/S2589004223024252
Oct 2023
www.embopress.org www.embopress.org

IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4+ T cells

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1. scibot 20 Oct 2023
  
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  RRID:AB_312691
  
  DOI: 10.15252/emmm.202317713
  
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embopress.org/doi/10.15252/emmm.202317713
www.cell.com www.cell.com

A micro-electroporation/electrophoresis-based vaccine screening system reveals the impact of vaccination orders on cross-protective immunity

1
1. scibot 13 Oct 2023
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.isci.2023.108086
  
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cell.com/iscience/abstract/S2589-0042(23)02163-6
Sep 2023
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Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow

1
1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113127
  
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sciencedirect.com/science/article/pii/S2211124723011397
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Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance

1
1. scibot 30 Sep 2023
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.ccell.2023.09.005
  
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sciencedirect.com/science/article/abs/pii/S1535610823003215
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Glucose Oxidation-Dependent Survival of Activated B Cells Provides a Putative Novel Therapeutic Target for Lupus Treatment

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1. scibot 26 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107487
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10448027/
52.53.155.43 52.53.155.43

CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells

2
1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101151
  
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2. scibot 11 Aug 2023
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.xcrm.2023.101151
  
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52.53.155.43/75914c2645b295883453ae6f0848b8ff04ccb7e0/PIIS266637912300304X-html.html
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice

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1. scibot 12 Aug 2023
  
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  DOI: 10.1038/s41392-023-01554-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10409725/
Jul 2023
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An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression

1
1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.immuni.2023.06.012
  
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sciencedirect.com/science/article/abs/pii/S1074761323002698
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Alcohol-sourced acetate impairs T cell function by promoting cortactin acetylation

1
1. scibot 15 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107230
  
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sciencedirect.com/science/article/pii/S258900422301307X
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Rebalancing liver-infiltrating CCR3+ and CD206+ monocytes improves diet-induced NAFLD

1
1. scibot 08 Jul 2023
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.celrep.2023.112753
  
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sciencedirect.com/science/article/pii/S2211124723007647
Jun 2023
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Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

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1. scibot 21 Jun 2023
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.cell.2023.05.027
  
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sciencedirect.com/science/article/pii/S0092867423005779
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Targeting 14-3-3ζ by a small-molecule compound AI-34 maintains epithelial barrier integrity and alleviates colitis in mice via stabilizing β-catenin

1
1. scibot 08 Jun 2023
  
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  AB_312691
  
  DOI: 10.1016/j.jphs.2023.05.004
  
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YTHDF2 inhibition potentiates radiotherapy antitumor efficacy

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Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis

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EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

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The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

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IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment

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Opioid-induced fragile-like regulatory T cells contribute to withdrawal

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Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection

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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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Cbl-b Restrains Priming of Pathogenic Th17 Cells via the Inhibition of IL-6 Production by Macrophages

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Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease

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Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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Phospholipid metabolites of the gut microbiota promote hypoxia-induced intestinal injury via CD1d-dependent γδ T cells

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Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

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Envelope virus-mimetic nanovaccines by hybridizing bioengineered cell membranes with bacterial vesicles

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A humanized β2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo

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Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion

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ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection

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RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants

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Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection

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ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

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A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

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Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

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Two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge

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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

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Arthritis flares mediated by tissue-resident memory T cells in the joint

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Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity

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Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza

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Protocol for analyzing and visualizing antiviral immune responses after acute infection of the murine oral mucosa

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Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

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Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma

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May 2021
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Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

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Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection

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  DOI: 10.1016/j.celrep.2021.109160
  
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sciencedirect.com/science/article/pii/S2211124721005027
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Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium

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  DOI: 10.1016/j.immuni.2020.12.004
  
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sciencedirect.com/science/article/pii/S107476132030532X
Apr 2021
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CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

1
1. scibot 26 Apr 2021
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.cmet.2021.02.015
  
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sciencedirect.com/science/article/pii/S1550413121000711
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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

1
1. scibot 15 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108966
  
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sciencedirect.com/science/article/pii/S2211124721002801
Mar 2021
elifesciences.org elifesciences.org

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

1
1. scibot 28 Mar 2021
  
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  DOI: 10.7554/eLife.61798
  
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elifesciences.org/articles/61798
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

1
1. scibot 02 Mar 2021
  
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  DOI: 10.3389/fimmu.2020.614667
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7897681/
Nov 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

1
1. scibot 07 Nov 2020
  
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  DOI: 10.1016/j.celrep.2020.108331
  
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pubmed.ncbi.nlm.nih.gov/33147448/
Sep 2020
academic.oup.com academic.oup.com

Roles of endogenous IL-10 and IL-10-competent CD1d hi and CD5 + B cells in autoimmune thyroiditis in NOD.H-2 h4 mice

1
1. scibot 26 Sep 2020
  
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  RRID:AB_312691
  
  DOI: 10.1210/endocr/bqaa033
  
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academic.oup.com/endo/article/161/4/bqaa033/5802318
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Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation

1
1. scibot 17 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107819
  
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sciencedirect.com/science/article/pii/S2211124720308007
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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

1
1. scibot 16 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.02.050
  
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sciencedirect.com/science/article/pii/S0092867420302270
portlandpress.com portlandpress.com

Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

1
1. scibot 15 Sep 2020
  
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  RRID:AB_312691
  
  DOI: 10.1042/CS20200021
  
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portlandpress.com/clinsci/article/134/13/1679/225508/Neutrophil-elastase-triggers-the-development-of
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An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

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1. scibot 13 Sep 2020
  
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  DOI: 10.1016/j.cell.2020.04.030
  
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sciencedirect.com/science/article/pii/S0092867420304931
insight.jci.org insight.jci.org

Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

1
1. scibot 10 Sep 2020
  
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  RRID: AB_312691
  
  DOI: 10.1172/jci.insight.134386
  
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insight.jci.org/articles/view/134386
Jan 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

1
1. scibot 13 Jan 2020
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.celrep.2019.03.066
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6719696/
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TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

1
1. scibot 13 Jan 2020
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.celrep.2019.05.061
  
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sciencedirect.com/science/article/pii/S2211124719306904
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Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

1
1. scibot 13 Jan 2020
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.molcel.2019.08.005
  
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sciencedirect.com/science/article/pii/S1097276519306215
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Survival of Naïve T Cells Requires the Expression of Let-7 miRNAs

1
1. scibot 13 Jan 2020
  
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  AB_312691
  
  DOI: 10.3389/fimmu.2019.00955
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6509570/
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Untitled document

1
1. scibot 13 Jan 2020
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.immuni.2018.11.015
  
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sciencedirect.com/science/article/pii/S1074761318305235
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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

1
1. scibot 13 Jan 2020
  
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  RRID:AB_312691
  
  DOI: 10.1016/j.chom.2019.03.003
  
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sciencedirect.com/science/article/pii/S1931312819301155
Nov 2018
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Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1934590918303874
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Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S155041311830319X

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