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Sep 2026
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Combining pro-resolving therapy with cyclosporine A restores immune homeostasis and reduces toxicity in autoimmune bone marrow failure

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Jul 2026
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Direct interaction of Vδ7 TCRs with IL17RA drives the differentiation of TH1-like γδT cells

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  DOI: 10.1126/science.adx9264
  
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science.org/doi/10.1126/science.adx9264
Jun 2026
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Genetic ablation of Sfxn5 induces mitochondrial dysfunction and precipitates lethal metabolic crisis in mice

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STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer

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Apr 2026
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An inhalable microbe-oncolytic virus consortium for lung cancer treatment

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Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy

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  DOI: 10.1158/2159-8290.CD-25-0649
  
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aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
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Dual-targeted microspheres reshape the metabolic-immune microenvironment to reverse post-embolization dilemmas in hepatocellular carcinoma

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Pan-cancer macrophage atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions

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sciencedirect.com/science/article/pii/S2211124726003086
Mar 2026
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pH-regulating Lipiodol Pickering emulsions enhance transarterial embolization therapy via inducing ferroptosis and activating antitumor immunity

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RORγt Inhibition Reduces Pro-Tumor Inflammation and Decreases Tumor Growth in Experimental Models of Lung Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12288671/
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Hematopoietic stem cells activate a latent differentiation pathway to facilitate recovery after 5-fluorouracil-induced myeloablation

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Feb 2026
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Identifying microbial protease allergens through protein language model-guided homology

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sciencedirect.com/science/article/pii/S2405471225003436
54.241.53.176 54.241.53.176

1-s2.0-S2589004226004128-main-html.html

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1. scibot 19 Feb 2026
  
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Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

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sciencedirect.com/science/article/pii/S1074761326000385
Jan 2026
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Mucosal innate immune activation as the trigger to Prevotella species-induced arthritis in genetically resistant mice

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sciencedirect.com/science/article/pii/S221112472501527X
Dec 2025
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Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.neuron.2025.11.006
  
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An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery

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sciencedirect.com:5037/science/article/pii/S2666379125005889
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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1. scibot 29 Nov 2025
  
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Fluorinated prodrug-engineered nano-remodeler relieves tumor hypoxia for dual-enhanced ferroptosis-immunotherapy

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1. scibot 13 Nov 2025
  
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CD94/NKG2A-Qa-1b axis as a key modulator of vaccine responsiveness in aging populations

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Oct 2025
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Treg-microglia partnership in the injured spinal cord preserves Treg cell function and regulates microglial cholesterol metabolism

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Sep 2025
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Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells

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Aug 2025
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Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

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Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease

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sciencedirect.com/science/article/pii/S2211124725009271
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1-s2.0-S2589004225010338-main-html.html

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52.53.155.43/8b0897d2d35a8ab9ab351db77e0eeb32b8358112/1-s2.0-S2589004225010338-main-html.html
Jul 2025
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RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression

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  DOI: 10.1158/2159-8290.CD-24-0199
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223513/
Jun 2025
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BPS Publications

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  DOI: 10.1111/bph.17473
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17473
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Immune imprinting blunts omicron pathogenicity fluctuations and highlights the essential role of cellular immunity in SARS-CoV-2 infection

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Apr 2025
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PDF-html.html

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The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function

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Mar 2025
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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Feb 2025
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OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity

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Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection

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1. scibot 14 Feb 2025
  
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  DOI: 10.1371/journal.ppat.1012906
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11813105/
Dec 2024
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CD4+ T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/sciimmunol.adp6529
  
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science.org/doi/10.1126/sciimmunol.adp6529
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EAF2 deficiency attenuates autoimmune disease in Faslpr mice by modulating B cell activation and apoptosis

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1. scibot 19 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111220
  
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Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets

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1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111248
  
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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CD4+ T cells with convergent TCR recombination reprogram stroma and halt tumor progression in adoptive therapy

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  DOI: 10.1126/sciimmunol.adp6529
  
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Development of a CD39 nanobody and its enhancement to chimeric antigen receptor T cells efficacy against ovarian cancer in preclinical studies

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Aug 2024
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Indirect suppression of CD4 T cell activation through LAG-3-mediated trans-endocytosis of MHC class II

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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

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Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers

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May 2024
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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation

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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment

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The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

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Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms

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Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch

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Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis

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Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

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IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

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S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis

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Jun 2023
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

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Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

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RORψt+CD4+ T cells promote IL-23R-mediated neuronal cell apoptosis in the central nervous system

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May 2023
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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

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Cooperative super-enhancer inactivation caused by heterozygous loss of CREBBP and KMT2D skews B cell fate decisions and yields T cell-depleted lymphomas

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Mar 2023
europepmc.org europepmc.org

Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance

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Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes

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Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

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RAGE deficiency ameliorates autoimmune hepatitis involving inhibition of IL-6 production via suppressing protein Arid5a in mice

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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ

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FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism

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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

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Identification and characterization of innate lymphoid cells generated from pluripotent stem cells

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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

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Quantitative Increase in T Regulatory Cells Enhances Bone Remodeling in Osteogenesis Imperfecta

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  DOI: 10.1016/j.isci.2022.104818
  
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Large-scale multiplexed mosaic CRISPR perturbation in the whole organism

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B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation

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Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses

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Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function

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ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection

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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics

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A defective viral genome strategy elicits broad protective immunity against respiratory viruses

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Insular cortex neurons encode and retrieve specific immune responses

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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

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Differential m6A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function

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Methods for Studying Mouse and Human Invariant Natural Killer T Cells

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Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization

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Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration

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Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

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Untitled document

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Untitled document

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Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation

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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

1
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

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Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras

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CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

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Jan 2020
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Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses

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Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

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Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

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Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

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Untitled document

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Untitled document

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Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors

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Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism

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CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

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Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

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Untitled document

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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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Nov 2017
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CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression

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Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation

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The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

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Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy

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