126 Matching Annotations
  1. Last 7 days
  2. www.cell.com www.cell.com
    Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening
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    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.stem.2024.06.007

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    cell.com/cell-stem-cell/abstract/S1934-5909(24)00215-7
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy
    1
    1. scibot 14 Jul 2024
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      DOI: 10.1016/j.isci.2024.110189

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233966/
  4. Jul 2024
  5. www.cell.com www.cell.com
    GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development
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    1. scibot 11 Jul 2024
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    cell.com/developmental-cell/abstract/S1534-5807(24)00385-X
  6. Jun 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts antitumor efficacy through T cell engagement
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      DOI: 10.1016/j.xcrm.2024.101590

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    sciencedirect.com/science/article/pii/S2666379124002829
  8. www.nature.com www.nature.com
    A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice
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    1. scibot 06 Jun 2024
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      DOI: 10.1038/s41590-024-01834-9

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    nature.com/articles/s41590-024-01834-9
  9. May 2024
  10. www.sciencedirect.com www.sciencedirect.com
    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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    1. scibot 14 May 2024
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    sciencedirect.com/science/article/pii/S0092867424004483
  11. 52.53.155.43 52.53.155.43
    Sufficient Water Intake Maintains the Gut Microbiota and Immune Homeostasis and Promotes Pathogen Elimination
    1
    1. scibot 09 May 2024
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    52.53.155.43/40c2bd88cce950d40abdb8d3c651218df4813562/PIIS2589004224011258-html.html
  12. Apr 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection
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    1. scibot 18 Apr 2024
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      DOI: 10.1101/2024.03.21.586160

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    ncbi.nlm.nih.gov/pmc/articles/PMC10996474/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1158/1535-7163.MCT-23-0336

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993987/
  15. www.sciencedirect.com www.sciencedirect.com
    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114041

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    sciencedirect.com/science/article/pii/S2211124724003693
  16. Mar 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Derivation of functional thymic epithelial organoid lines from adult murine thymus
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    1. scibot 29 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724003474
  18. Feb 2024
  19. www.mdpi.com www.mdpi.com
    The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model
    1
    1. scibot 15 Feb 2024
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      DOI: 10.3390/ijms25031880

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    mdpi.com/1422-0067/25/3/1880
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alleviation of monocyte exhaustion by BCG derivative mycolic acid
    1
    1. scibot 08 Feb 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10845070/
  21. www.sciencedirect.com www.sciencedirect.com
    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
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    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.chembiol.2024.01.002

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    sciencedirect.com/science/article/pii/S2451945624000382
  22. Jan 2024
  23. www.sciencedirect.com www.sciencedirect.com
    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.cmet.2023.12.016

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    sciencedirect.com/science/article/pii/S1550413123004679
  24. www.sciencedirect.com www.sciencedirect.com
    A time- and single-cell-resolved model of murine bone marrow hematopoiesis
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.stem.2023.12.001

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    sciencedirect.com/science/article/pii/S1934590923004319
  25. Nov 2023
  26. www.sciencedirect.com www.sciencedirect.com
    The antitumor activities of anti-CD47 antibodies require Fc-FcγR interactions
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/pii/S153561082300363X
  27. www.sciencedirect.com www.sciencedirect.com
    Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses
    1
    1. scibot 18 Nov 2023
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      DOI: 10.1016/j.isci.2023.108348

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    sciencedirect.com/science/article/pii/S2589004223024252
  28. www.biorxiv.org www.biorxiv.org
    One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1101/2023.11.06.565713

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    biorxiv.org/content/10.1101/2023.11.06.565713v1
  29. Oct 2023
  30. www.embopress.org www.embopress.org
    Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis
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    1. scibot 21 Oct 2023
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      DOI: 10.15252/embr.202357653

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    embopress.org/doi/10.15252/embr.202357653
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Detection of the CD8+ T cell immune response in mice infected with OVA-Listeriamonocytogenes
    1
    1. scibot 07 Oct 2023
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      DOI: 10.1016/j.xpro.2023.102582

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    ncbi.nlm.nih.gov/pmc/articles/PMC10550835/
  32. Sep 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Low dietary fiber intake impairs small intestinal Th17 and intraepithelial T cell development over generations
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113140

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    sciencedirect.com/science/article/pii/S221112472301152X
  34. Aug 2023
  35. www.sciencedirect.com www.sciencedirect.com
    Endogenous CCL21-Ser deficiency reduces B16–F10 melanoma growth by enhanced antitumor immunity
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    1. scibot 23 Aug 2023
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      DOI: 10.1016/j.heliyon.2023.e19215

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    sciencedirect.com/science/article/pii/S240584402306423X
  36. Jul 2023
  37. www.sciencedirect.com www.sciencedirect.com
    An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.immuni.2023.06.012

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    sciencedirect.com/science/article/abs/pii/S1074761323002698
  38. onlinelibrary.wiley.com onlinelibrary.wiley.com
    CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth
    1
    1. scibot 13 Jul 2023
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      DOI: 10.1111/cas.15902

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    onlinelibrary.wiley.com/doi/10.1111/cas.15902
  39. Jun 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s
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    1. scibot 09 Jun 2023
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    sciencedirect.com/science/article/pii/S2211124723006216
  41. www.sciencedirect.com www.sciencedirect.com
    Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow
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    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112580

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    sciencedirect.com/science/article/pii/S2211124723005910
  42. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1016/j.ccell.2023.05.005

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    sciencedirect.com/science/article/pii/S1535610823001733
  43. May 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Helicobacter spp. are prevalent in wild mice and protect from lethal Citrobacter rodentium infection in the absence of adaptive immunity
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    1. scibot 31 May 2023
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      DOI: 10.1016/j.celrep.2023.112549

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    sciencedirect.com/science/article/pii/S2211124723005600
  45. www.sciencedirect.com www.sciencedirect.com
    Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer
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    sciencedirect.com/science/article/pii/S153561082300137X
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    T helper 1 effector memory CD4+ T cells protect the skin from poxvirus infection
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    1. scibot 22 Apr 2023
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    sciencedirect.com/science/article/pii/S2211124723004187
  48. www.sciencedirect.com www.sciencedirect.com
    NK cell-derived extracellular granzyme B drives epithelial ulceration during HSV-2 genital infection
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    sciencedirect.com/science/article/pii/S2211124723004217
  49. www.sciencedirect.com www.sciencedirect.com
    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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    sciencedirect.com/science/article/pii/S1097276523000837
  50. Mar 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
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    sciencedirect.com/science/article/pii/S1074761323000924
  52. www.sciencedirect.com www.sciencedirect.com
    Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow
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    sciencedirect.com/science/article/pii/S153458072300045X
  53. Feb 2023
  54. www.sciencedirect.com www.sciencedirect.com
    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    sciencedirect.com/science/article/pii/S2211124723001407
  55. www.sciencedirect.com www.sciencedirect.com
    Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes
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    sciencedirect.com/science/article/pii/S1074761323000353
  56. www.sciencedirect.com www.sciencedirect.com
    Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer
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    1. scibot 11 Feb 2023
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      DOI: 10.1016/j.celrep.2023.112090

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    sciencedirect.com/science/article/pii/S2211124723001018
  57. www.sciencedirect.com www.sciencedirect.com
    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    sciencedirect.com/science/article/pii/S153561082300003X
  58. Dec 2022
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunostaining of tumor-infiltrating immune-cell-related markers and cytokines in the tumor fractional radiation model of host PD-L1-deficient mice
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      DOI: 10.1016/j.xpro.2022.101859

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  60. Nov 2022
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    Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
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    Protocol to isolate mature thymic T cell subsets using fluorescence-activated cell sorting for assessing gene expression by RNA-seq and transcription factor binding across the genome by CUT&RUN
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    Identification and characterization of innate lymphoid cells generated from pluripotent stem cells
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  64. Oct 2022
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    Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells
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  66. Sep 2022
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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination
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    Neisseria species as pathobionts in bronchiectasis
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  70. Aug 2022
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    Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
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    Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis
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  74. Jul 2022
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    Large-scale multiplexed mosaic CRISPR perturbation in the whole organism
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    Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation
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    B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation
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  79. Jun 2022
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    Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
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    Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function
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  82. Apr 2022
  83. academic.oup.com academic.oup.com
    Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells
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    Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
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  85. Mar 2022
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    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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    Distinct hepatic immunological patterns are associated with the progression or inhibition of hepatocellular carcinoma
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  88. Feb 2022
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    Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity
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  90. Dec 2021
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    Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity
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  92. Sep 2021
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    Protocol for analyzing and visualizing antiviral immune responses after acute infection of the murine oral mucosa
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    Methods for Studying Mouse and Human Invariant Natural Killer T Cells
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    Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes
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  96. Aug 2021
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    Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration
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    Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection
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    Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection
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  103. Jul 2021
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    A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus
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  106. Jun 2021
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    A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection
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  108. May 2021
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    The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth
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    Resident memory T cells in tumor-distant tissues fortify against metastasis formation
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    A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustains their immunosuppressive function in melanoma
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    Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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  114. Apr 2021
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    Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
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    Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome
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    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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    Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the β-selection checkpoint
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    Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors
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    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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  126. Jan 2021
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    Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection
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  128. Nov 2020
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    Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity
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  131. Oct 2020
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    PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
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    Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis
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    Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function
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    The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection
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    Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts
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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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  140. Jan 2020
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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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    STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
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    Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses
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    IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8α+ Dendritic Cells Promotes Listeria monocytogenes Infection
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    NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells
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    Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity
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    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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    HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
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    Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
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  155. Nov 2018
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
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    Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression
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    Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment
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    The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation
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    Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity
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    Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
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      RRID:AB_312751
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    ncbi.nlm.nih.gov/pmc/articles/PMC5786505/
  163. www.sciencedirect.com www.sciencedirect.com
    CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
    1
    1. scibot 05 Nov 2018
      RRID:AB_312751

      Resource used:

      (BioLegend Cat# 100712, RRID:AB_312751)

      SciCrunch record: RRID:AB_312751

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_312751
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    sciencedirect.com/science/article/pii/S1550413117306186
  164. Nov 2017
  165. www.sciencedirect.com www.sciencedirect.com
    Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation
    1
    1. scibot 08 Nov 2017
      RRID:AB_312751

      Curator: @Jmenke

      Resource used:

      (BioLegend Cat# 100712, RRID:AB_312751)

      SciCrunch record: RRID:AB_312751

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_312751 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761317303631
  166. www.sciencedirect.com www.sciencedirect.com
    Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells
    1
    1. scibot 08 Nov 2017
      RRID:AB_312751

      Curator: @Jmenke

      Resource used:

      (BioLegend Cat# 100712, RRID:AB_312751)

      SciCrunch record: RRID:AB_312751

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_312751 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761317303151
  167. www.sciencedirect.com www.sciencedirect.com
    Induction of Live Cell Phagocytosis by a Specific Combination of Inflammatory Stimuli
    1
    1. scibot 08 Nov 2017
      AB_312751

      Curator: @chewbeccax

      Resource used:

      (BioLegend Cat# 100712, RRID:AB_312751)

      SciCrunch record: RRID:AB_312751

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_312751 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2352396417302840