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Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages

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  DOI: 10.1016/j.immuni.2025.11.015
  
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sciencedirect.com:5037/science/article/pii/S1074761325005175
Nov 2025
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MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors

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Virus envelope glycoprotein targeting bispecific T cell engager protects mice from lethal severe fever with thrombocytopenia virus infection

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.xcrm.2025.102458
  
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Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116526
  
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sciencedirect.com/science/article/pii/S2211124725012975
Oct 2025
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2025.10.24.684274v1.full-html.html

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  DOI: 10.1101/2025.10.24.684274
  
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54.241.53.176/560b23241d86210770f41b5bc2071167c8b2fca6/2025.10.24.684274v1.full-html.html
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The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function

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  DOI: 10.1016/j.neuron.2025.09.032
  
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In situ extended immune activation instantly after tumor resection by oncolytic virus controls postoperative tumor recurrence

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CD169+ macrophages identify and eliminate tumor cells in colorectal cancer through CD169/CD43 interaction and FasL-driven apoptosis

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  DOI: 10.1016/j.celrep.2025.116351
  
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sciencedirect.com/science/article/pii/S2211124725011222
Sep 2025
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Targeting lysozyme 2 in endocardium promotes rapid recovery by modulating remote injury signals

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1. scibot 18 Sep 2025
  
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  DOI: 10.1016/j.stem.2025.08.015
  
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Aug 2025
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Long-range deployment of tumor-antigen-specific cytotoxic T lymphocytes inhibits lung metastasis of breast cancer

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1. scibot 28 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.08.003
  
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BACH2 promotes seeding and establishment of long-lived HIV-1 reservoir in memory CD4+ T cells

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102311
  
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Fibroblast bioelectric signaling drives hair growth

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.035
  
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CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases

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1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.007
  
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sciencedirect.com/science/article/pii/S1535610825003137
Jul 2025
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TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115972
  
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cell.com/cell-reports/abstract/S2211-1247(25)00743-0
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TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.015
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00265-X
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APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps

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1. scibot 02 Jul 2025
  
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  DOI: 10.1371/journal.ppat.1013267
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12201663/
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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.006
  
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sciencedirect.com/science/article/pii/S1074761325002754
Jun 2025
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.029
  
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May 2025
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Combinatorial treatment with upadacitinib abrogates systemic toxicity of a tumor-targeted IL-2 fusion protein

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1. scibot 20 May 2025
  
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  DOI: 10.1136/jitc-2024-010831
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12067867/
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KMT2C deficiency drives transdifferentiation of double-negative prostate cancer and confer resistance to AR-targeted therapy

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  DOI: 10.1016/j.ccell.2025.04.002
  
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Apr 2025
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Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis

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  DOI: 10.1016/j.xcrm.2025.102047
  
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Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance

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  DOI: 10.1158/1078-0432.CCR-23-3616
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
Mar 2025
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Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.02.031
  
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23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation

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1. scibot 27 Mar 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0478
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
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Modulation of lipid nanoparticle-formulated plasmid DNA drives innate immune activation promoting adaptive immunity

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  DOI: 10.1016/j.xcrm.2025.102035
  
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cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00108-9
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Bmal1 deficiency in neutrophils alleviates symptoms induced by high-fat diet

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  DOI: 10.1016/j.isci.2025.112038
  
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RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress

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  DOI: 10.1186/s12974-024-03322-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11852585/
Feb 2025
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A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy

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  DOI: 10.1016/j.celrep.2025.115301
  
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Jan 2025
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in stroke

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  DOI: 10.1016/j.ebiom.2025.105568
  
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Neutrophil extracellular traps promote pre-metastatic niche formation in the omentum by expanding innate-like B cells that express IL-10

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  DOI: 10.1016/j.ccell.2024.12.004
  
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Dec 2024
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Fibroblast-Mediated Macrophage Recruitment Supports Acute Wound Healing

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  DOI: 10.1016/j.jid.2024.10.609
  
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sciencedirect.com/science/article/pii/S0022202X24029567
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Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis

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  DOI: 10.1016/j.immuni.2024.11.004
  
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Nov 2024
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Meningeal neutrophil immune signaling influences behavioral adaptation following threat

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.neuron.2024.10.018
  
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Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.cell.2024.10.042
  
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p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb

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1. scibot 21 Nov 2024
  
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  DOI: 10.1038/s44318-024-00246-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574164/
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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

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  DOI: 10.1016/j.cell.2024.10.010
  
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Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection

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  DOI: 10.1016/j.celrep.2024.114951
  
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Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment

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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

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  DOI: 10.1016/j.ccell.2024.10.008
  
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Oct 2024
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A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustains their immunosuppressive function in melanoma

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  DOI: 10.1158/0008-5472.CAN-20-3510
  
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The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice

1
1. scibot 02 Oct 2024
  
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  DOI: 10.1073/pnas.2407768121
  
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Jawbone periosteum-derived cells with high osteogenic potential controlled by R-spondin 3

1
1. scibot 02 Oct 2024
  
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  DOI: 10.1096/fj.202400988RR
  
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Sep 2024
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Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium

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Baf155 controls hematopoietic differentiation and regeneration through chromatin priming

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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism

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Protein-energy restriction-induced lipid metabolism disruption causes stable-to-progressive disease shift in Mycobacterium avium-infected female mice

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Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma

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May 2024
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TREX1 inactivation unleashes cancer cell STING-interferon signaling and promotes anti-tumor immunity

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  DOI: 10.1158/2159-8290.CD-23-0700
  
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Apr 2024
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CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment

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Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

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Type-I-interferon-responsive microglia shape cortical development and behavior

2
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  DOI: 10.1016/j.cell.2024.02.020
  
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The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression

2
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EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas

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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis

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  DOI: 10.1038/s41416-023-02556-9
  
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Nov 2023
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Prolonged sleep deprivation induces a cytokine-storm-like syndrome in mammals

1
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cell.com/cell/abstract/S0092-8674(23)01176-5
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The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice

1
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  DOI: 10.1101/2023.11.21.568190
  
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biorxiv.org/content/10.1101/2023.11.21.568190v1
Oct 2023
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Decoding aging-dependent regenerative decline across tissues at single-cell resolution

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  DOI: 10.1016/j.stem.2023.09.014
  
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Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration

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  DOI: 10.1126/sciadv.adi1891
  
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Aug 2023
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Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome

1
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  DOI: 10.1016/j.celrep.2023.112990
  
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Jul 2023
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CCL21-Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth

1
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  DOI: 10.1111/cas.15902
  
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onlinelibrary.wiley.com/doi/10.1111/cas.15902
Jun 2023
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LRRC15 expression indicates high level of stemness regulated by TWIST1 in mesenchymal stem cells

1
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  DOI: 10.1016/j.isci.2023.106946
  
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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

1
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  DOI: 10.1016/j.ccell.2023.05.016
  
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Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

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  DOI: 10.1016/j.molcel.2023.05.035
  
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Systematic dissection of coordinated stromal remodeling identifies Sox10+ glial cells as a therapeutic target in myelofibrosis

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  DOI: 10.1016/j.stem.2023.05.002
  
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Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation

1
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  DOI: 10.1016/j.immuni.2023.05.004
  
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May 2023
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Homeostatic activation of aryl hydrocarbon receptor by dietary ligands dampens cutaneous allergic responses by controlling Langerhans cells migration

1
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  DOI: 10.7554/eLife.86413
  
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Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population

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  DOI: 10.1016/j.celrep.2023.112501
  
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Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer

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Mechanical isolation of neonatal and adult mouse dura leukocytes for flow cytometry analysis

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Massively parallel base editing to map variant effects in human hematopoiesis

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CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

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Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology

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Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging

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Whole-mount immunofluorescence imaging and isolation of mesothelium-bound immune cell aggregates during mouse peritoneal inflammation

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Neutrophil-activating therapy for the treatment of cancer

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Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes

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A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors

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Identification of hematopoietic stem cells residing in the meninges of adult mice at steady state

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Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

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Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance

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Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

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Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis

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Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism

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Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine

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Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

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Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells

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Single-cell atlas of the aging mouse colon

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Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses

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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

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Uhrf1 governs the proliferation and differentiation of muscle satellite cells

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Cold exposure protects from neuroinflammation through immunologic reprogramming

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Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges

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Isolation of mouse Kupffer cells for phenotypic and functional studies

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Tracing the skeletal progenitor transition during postnatal bone formation

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Untitled document

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Untitled document

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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

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The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

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  DOI: 10.1111/bph.15488
  
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Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells

1
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Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials

1
1. scibot 30 Apr 2021
  
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  anti-CD45
  
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Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

1
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  DOI: 10.1016/j.cell.2020.05.050
  
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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy

1
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  RRID:AB_312973
  
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Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

1
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Airway-Associated Macrophages in Homeostasis and Repair

1
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Distinct developmental pathways from blood monocytes generate human lung macrophage diversity

1
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Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

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Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis

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  RRID:AB_312973
  
  DOI: 10.1186/s40478-020-01020-6
  
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Characterization of Resident Corneal Plasmacytoid Dendritic Cells and Their Pivotal Role in Herpes Simplex Keratitis

1
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Nov/CCN3 Enhances Cord Blood Engraftment by Rapidly Recruiting Latent Human Stem Cell Activity

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Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation

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Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

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  DOI: 10.1016/j.celrep.2020.107628
  
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Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity

1
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  RRID:AB_312973
  
  DOI: 10.1016/j.cell.2020.02.015
  
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Changes in the transcriptional fingerprint of satellite glial cells following peripheral nerve injury

1
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  AB_312973
  
  DOI: 10.1002/glia.23785
  
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onlinelibrary.wiley.com/doi/10.1002/glia.23785
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An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

1
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A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

1
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UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

1
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  RRID:AB_312973
  
  DOI: 10.1016/j.cell.2019.08.032
  
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STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

1
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  AB_312973
  
  DOI: 10.1016/j.cmet.2019.10.013
  
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cell.com/cell-metabolism/fulltext/S1550-4131(19)30604-7
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A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion

1
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  DOI: 10.1016/j.celrep.2019.09.045
  
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Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation

1
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  DOI: 10.1016/j.celrep.2019.05.019
  
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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

1
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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

1
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  DOI: 10.1016/j.celrep.2019.03.066
  
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Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

1
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  DOI: 10.1016/j.chom.2019.10.008
  
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Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

1
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  DOI: 10.1016/j.cmet.2019.07.015
  
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cell.com/cell-metabolism/fulltext/S1550-4131(19)30428-0
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A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

1
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  DOI: 10.1016/j.chom.2019.06.003
  
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sciencedirect.com/science/article/pii/S1931312819302926
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Untitled document

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  DOI: 10.1016/j.celrep.2019.04.074
  
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Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

1
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  DOI: 10.1016/j.ccell.2019.02.003
  
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Untitled document

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  DOI: 10.1016/j.neuron.2019.01.012
  
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Untitled document

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  DOI: 10.1016/j.stem.2019.01.011
  
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Untitled document

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  DOI: 10.1016/j.immuni.2019.03.013
  
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Nov 2018
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Untitled document

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Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_312973
  
  Curator: @Jmenke
  
  Resource used:
  
  (BioLegend Cat# 103108, RRID:AB_312973)
  
  SciCrunch record: RRID:AB_312973
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_312973 RRIDCUR:Validated
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RRID:AB_312973

RRIDCUR:Validated

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scibot

URL

sciencedirect.com/science/article/pii/S1934590918304375
www.jneurosci.org www.jneurosci.org

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1
1. scibot 05 Nov 2018
  
  in Public
  
  RRID:AB_312973
  
  Resource used:
  
  (BioLegend Cat# 103108, RRID:AB_312973)
  
  SciCrunch record: RRID:AB_312973
  
  Alternate resolvers: SciCrunch xml N2T identifiers.org
  
  What is this?
  
  RRID:AB_312973
Visit annotations in context

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RRID:AB_312973

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scibot

URL

jneurosci.org/content/38/1/200

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