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Psychological stress drives aging-like hematopoietic stem cell dysfunction through a brain-gut-bone marrow axis

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1. scibot 05 Jul 2026
  
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  DOI: 10.1016/j.stem.2026.05.012
  
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sciencedirect.com/science/article/pii/S1934590926002043
Jun 2026
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The MLLT3 YEATS domain binds histone marks (H3K9/18/27ac/cr) and ncRNA (7SK), linking transcription and RNA signaling to regulate hematopoiesis

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1. scibot 10 Jun 2026
  
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  DOI: 10.1016/j.celrep.2026.117540
  
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sciencedirect.com/science/article/pii/S2211124726006182
May 2026
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A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression

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1. scibot 12 May 2026
  
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  DOI: 10.1016/j.stem.2026.04.013
  
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sciencedirect.com/science/article/pii/S1934590926001530
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A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity

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1. scibot 12 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.005
  
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sciencedirect.com/science/article/pii/S1534580726001528
Mar 2026
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FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102686
  
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sciencedirect.com/science/article/pii/S2666379126001035
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Kindlin-2-mediated hematopoiesis remodeling regulates triple-negative breast cancer immune evasion

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1. scibot 18 Mar 2026
  
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  DOI: 10.1158/1541-7786.MCR-24-0698
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12977202/
Feb 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation

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1. scibot 12 Feb 2026
  
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  DOI: 10.1016/j.isci.2026.114738
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12886522/
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CCL3 is produced by aged neutrophils across cancers and promotes tumor growth

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1. scibot 06 Feb 2026
  
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  DOI: 10.1016/j.ccell.2026.01.006
  
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sciencedirect.com/science/article/pii/S1535610826000450
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops

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1. scibot 09 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116650
  
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sciencedirect.com:5037/science/article/pii/S2211124725014226
Nov 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225022710-main-html.html

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1. scibot 13 Nov 2025
  
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  AB_313221
  
  DOI: 10.1371/journal.pcbi.1010962
  
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54.241.53.176/201c781a90c73f7d86de4c0e927fdae59f85908d/1-s2.0-S2589004225022710-main-html.html
Oct 2025
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Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation

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1. scibot 02 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116379
  
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sciencedirect.com/science/article/pii/S2211124725011507
Sep 2025
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Mitochondrial-activity-driven hematopoietic stem cell fate and lineage choice is first established in the aorta-gonad-mesonephros

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116296
  
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sciencedirect.com/science/article/pii/S2211124725010678
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OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

1
1. scibot 17 Sep 2025
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.cmet.2025.08.008
  
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sciencedirect.com/science/article/pii/S155041312500381X
May 2025
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115735
  
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sciencedirect.com/science/article/pii/S2211124725005066
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Myeloid-lineage-specific membrane protein LRRC25 suppresses immunity in solid tumor and is a potential cancer immunotherapy checkpoint target

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1. scibot 16 May 2025
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.celrep.2025.115631
  
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sciencedirect.com/science/article/pii/S2211124725004024
Apr 2025
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Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model

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1. scibot 24 Apr 2025
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.celrep.2025.115612
  
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sciencedirect.com/science/article/pii/S2211124725003833
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Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen

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1. scibot 03 Apr 2025
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.celrep.2025.115494
  
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sciencedirect.com/science/article/pii/S2211124725002657
Mar 2025
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Decoding the ontogeny of myeloid lineage diversity by cross-species and developmental analyses of hematopoietic progenitor atlases

1
1. scibot 11 Mar 2025
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.celrep.2025.115406
  
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sciencedirect.com/science/article/pii/S2211124725001779
Dec 2024
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Staphylococcus aureus induced trained immunity in macrophages confers heterologous protection against gram-negative bacterial infection

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1. scibot 18 Dec 2024
  
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  AB_313221
  
  DOI: 10.1016/j.isci.2024.111284
  
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sciencedirect.com/science/article/pii/S2589004224025094
Jul 2024
www.cell.com www.cell.com

Nynrin preserves hematopoietic stem cell function by inhibiting the mitochondrial permeability transition pore opening

1
1. scibot 16 Jul 2024
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.stem.2024.06.007
  
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cell.com/cell-stem-cell/abstract/S1934-5909(24)00215-7
Feb 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

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1. scibot 07 Feb 2024
  
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  DOI: 10.1038/s41467-024-45471-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10844594/
Dec 2023
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Non-canonical Hedgehog signaling mediates profibrotic hematopoiesis-stroma crosstalk in myeloproliferative neoplasms

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113608
  
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sciencedirect.com/science/article/pii/S2211124723016200
Sep 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Protocol for high-sensitivity western blot on murine hematopoietic stem cells

1
1. scibot 30 Sep 2023
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.xpro.2023.102578
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10519847/
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ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113163
  
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sciencedirect.com/science/article/pii/S2211124723011750
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Generation of mouse models carrying B cell restricted single or multiplexed loss-of-function mutations through CRISPR-Cas9 gene editing

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1. scibot 23 Sep 2023
  
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  DOI: 10.1016/j.xpro.2023.102165
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10510057/
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CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax

1
1. scibot 19 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113084
  
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sciencedirect.com/science/article/pii/S2211124723010951
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In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities

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1. scibot 07 Sep 2023
  
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  DOI: 10.1158/2643-3230.BCD-22-0082
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9975769/
Aug 2023
52.53.155.43 52.53.155.43

The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation

2
1. scibot 18 Aug 2023
  
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  RRID:AB_313221
  
  DOI: 10.1016/j.celrep.2023.112968
  
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2. scibot 16 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112968
  
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52.53.155.43/8a075ef675e11ca05cb4fe9fd629f036036ec570/PIIS2211124723009798-html.html
52.53.155.43 52.53.155.43

PTEN regulates hematopoietic lineage plasticity via PU.1-dependent chromatin accessibility

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1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112967
  
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2. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112967
  
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52.53.155.43/fc73699b69f68947fccc1396949d2b0acab3a956/PIIS2211124723009786-html.html
Jul 2023
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Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112794
  
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sciencedirect.com/science/article/pii/S2211124723008057
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

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1. scibot 24 Jun 2023
  
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  DOI: 10.7554/eLife.83004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10287155/
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Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

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1. scibot 22 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.05.035
  
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sciencedirect.com/science/article/pii/S1097276523004197
Apr 2023
52.53.155.43 52.53.155.43

An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

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1. scibot 05 Apr 2023
  
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  DOI: 10.1101/2023.02.10.528075
  
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52.53.155.43/7b3ec2d05d846404e9e7aaf3ab1e37fa63827484/2023.02.10.528075v1.full-html.html
Mar 2023
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m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis

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1. scibot 23 Mar 2023
  
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  DOI: 10.1016/j.molcel.2023.02.024
  
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sciencedirect.com/science/article/pii/S109727652300151X
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The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis

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Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells

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bcd-22-0082-html.html

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A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia

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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

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In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations

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Double knockin mice show NF-κB trajectories in immune signaling and aging

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Identification of hematopoietic stem cells residing in the meninges of adult mice at steady state

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Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function

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A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

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CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

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Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

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Jul 2022
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PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

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Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction

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Mar 2022
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Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells

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CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture

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Nov 2021
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Cell size is a determinant of stem cell potential during aging

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Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues

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Untitled document

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Untitled document

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Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

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Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells

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Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses

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A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

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m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

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Self-renewal of double-negative 3 early thymocytes enables thymus autonomy but compromises the β-selection checkpoint

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Mar 2021
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Ontogenic shifts in cellular fate are linked to proteotype changes in lineage-biased hematopoietic progenitor cells

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An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia

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Nov 2020
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Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors

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Oct 2020
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Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

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CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

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LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation

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An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

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Cell Competition, the Kinetics of Thymopoiesis, and Thymus Cellularity Are Regulated by Double-Negative 2 to 3 Early Thymocytes

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Protocol for Efficient CRISPR/Cas9/AAV-Mediated Homologous Recombination in Mouse Hematopoietic Stem and Progenitor Cells

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  DOI: 10.1016/j.xpro.2020.100028
  
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Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

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  DOI: 10.7554/eLife.41258
  
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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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  DOI: 10.1016/j.stem.2019.12.006
  
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Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

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  DOI: 10.1016/j.celrep.2019.08.065
  
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Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.05.028
  
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Untitled document

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  DOI: 10.7554/eLife.41258
  
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BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses

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  DOI: 10.15252/embj.2018100293
  
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Untitled document

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  DOI: 10.1016/j.stem.2019.03.021
  
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HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

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Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

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Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms

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