826 Matching Annotations
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    Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice
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  3. Nov 2024
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    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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    Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation
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    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    Midkine as a driver of age-related changes and increase in mammary tumorigenesis
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    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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    Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification
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    Bifunctional inhibitor reveals NEK2 as a therapeutic target and regulator of oncogenic pathways in lymphoma
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    PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
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  19. Aug 2024
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    MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation
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    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
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    Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model
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    Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT
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    Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model
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    CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway
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    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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  31. Jul 2024
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    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling
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    Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization
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    Decoding sunitinib resistance in ccRCC: Metabolic-reprogramming-induced ABAT and GABAergic system shifts
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    RHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
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    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease
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    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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  42. Jun 2024
  43. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis
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    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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  46. May 2024
  47. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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