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    Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
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    Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation
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  5. Jan 2025
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    Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis
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  7. Dec 2024
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    The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Genomic and transcriptomic landscape of human gastrointestinal stromal tumors
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    The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation
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    Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1
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    FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology
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    MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling
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    Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury
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    Impacts of APOE-ε4 and exercise training on brain microvascular endothelial cell barrier function and metabolism
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    CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells
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    Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates
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    DEP-1 is a brain insulin receptor phosphatase that prevents the simultaneous activation of counteracting metabolic pathways
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    PAPP-A as a Potential Target in Thyroid Eye Disease
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    Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice
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    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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    Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation
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    Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
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  29. Oct 2024
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    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    Midkine as a driver of age-related changes and increase in mammary tumorigenesis
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    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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  33. Sep 2024
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    Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
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    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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    Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification
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    Bifunctional inhibitor reveals NEK2 as a therapeutic target and regulator of oncogenic pathways in lymphoma
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    PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
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  41. Aug 2024
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    MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation
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    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
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    Human-induced pluripotent stem cell–derived neural stem cell exosomes improve blood–brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    Neuropeptide Y receptor activation preserves inner retinal integrity through PI3K/Akt signaling in a glaucoma mouse model
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    Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model
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    EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics
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  53. Jul 2024
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    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    RHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
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    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
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    Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis
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    A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin-treated rats
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    onlinelibrary.wiley.com/doi/10.1002/brb3.3398
  127. www.sciencedirect.com www.sciencedirect.com
    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.biopha.2024.116217

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    sciencedirect.com/science/article/pii/S0753332224000982
  128. Jan 2024
  129. www.nature.com www.nature.com
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    1. scibot 25 Jan 2024
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      DOI: 10.1038/s41388-024-02947-z

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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    1. scibot 20 Jan 2024
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      DOI: 10.1016/j.isci.2023.108733

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