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Apr 2026
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PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tumor immune escape in ovarian cancer

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Mar 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Insulin receptor trafficking and interactions in muscle cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12963976/
Feb 2026
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2026.02.11.705361v1.full-html.html

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54.241.53.176/5c618bd82011554652ee37be2d6b5f0590a656fa/2026.02.11.705361v1.full-html.html
Jan 2026
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Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target

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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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Apr 2025
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PDF-html.html

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52.53.155.43/b645d57731bbad4da56bb2d7f98fed3df22d621f/PDF-html.html
Mar 2025
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A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer

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Nov 2024
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Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus

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Apr 2024
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Mutant FOXO1 controls an oncogenic network via enhancer accessibility

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Oct 2023
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TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2

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Jul 2023
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Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

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nature.com/articles/s41467-023-39715-8
Apr 2023
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Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP

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Mar 2023
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Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats

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  DOI: 10.1152/ajpendo.00240.2021
  
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FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

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Jan 2023
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The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region

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Dec 2022
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Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

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Oct 2022
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MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling

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ncbi.nlm.nih.gov/pmc/articles/PMC9557906/
Aug 2022
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PH domain-mediated autoinhibition and oncogenic activation of Akt

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  DOI: 10.7554/eLife.80148
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9417420/
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Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

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sciencedirect.com/science/article/pii/S2211124722010774
Jul 2022
52.53.155.43 52.53.155.43

British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html

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52.53.155.43/eeb521b7ce9ed18aede2526ed77220c5d9e406f5/British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
May 2022
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Convergent somatic mutations in metabolism genes in chronic liver disease

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nature.com/articles/s41586-021-03974-6
Oct 2021
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PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory

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Sep 2021
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KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

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Aug 2021
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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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Untitled document

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sciencedirect.com/science/article/pii/S1534580718309286
Jul 2021
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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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May 2021
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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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Apr 2021
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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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sciencedirect.com/science/article/pii/S1550413120304204
Feb 2021
elifesciences.org elifesciences.org

The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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  DOI: 10.7554/eLife.61406
  
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Nov 2020
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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

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Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells

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  DOI: 10.1016/j.celrep.2020.108403
  
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Oct 2020
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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

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  DOI: 10.7554/eLife.58941
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7541086/
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The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development

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Skeletal muscle IGF-1 is lower at rest and after resistance exercise in humans with obesity

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  DOI: 10.1007/s00421-020-04509-z
  
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link.springer.com/article/10.1007/s00421-020-04509-z
Sep 2020
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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1. scibot 09 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107764
  
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Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

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  DOI: 10.1016/j.molcel.2019.07.023
  
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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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  DOI: 10.1016/j.celrep.2019.09.047
  
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WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis

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  DOI: 10.1016/j.devcel.2017.10.007
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.066
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.02.081
  
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Nov 2018
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Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

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Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling

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B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

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Untitled document

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Nov 2017
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The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells

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Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

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