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    Gut commensal Olsenella profusa promotes endometriosis via lysophosphatidylcholine metabolite
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    sciencedirect.com/science/article/pii/S2666379126003873
  3. May 2026
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    MicroRNA-200s attenuate demyelination caused by Angiostrongylus cantonensis in a mouse model by targeting phosphatase and tensin homolog
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    Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer
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  6. Jan 2026
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    Repression of Polycomb Group Factor 1 Inhibits EMT Progression in Colon Cancers Cells via Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathway
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  8. Oct 2025
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    Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity
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    Adipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing β-adrenergic signaling and lipolysis
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    4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia
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    Insulin potentiates mechanical responses in small dorsal root ganglion neurons by increasing the sensitization of TRPV4 channels
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  14. Aug 2025
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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  18. Jun 2025
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    PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling
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    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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  22. May 2025
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    Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation
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    Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
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  26. Dec 2024
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    Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity
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    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  29. Sep 2024
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    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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  31. Aug 2024
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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  33. Jul 2024
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    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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  35. Feb 2024
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    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    link.springer.com/article/10.1007/s12010-024-04887-6
  37. Dec 2023
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    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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  39. Oct 2023
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    Bilirubin impacts microglial autophagy via the Akt–mTOR signaling pathway
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  41. Aug 2023
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  43. Jul 2023
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    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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  47. Jun 2023
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    Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA
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  49. Apr 2023
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    Design of Diversified Chimeric Antigen Receptors Through Rational Module Recombination
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  51. Feb 2023
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    Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo
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  53. Jan 2023
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    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
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  55. Dec 2022
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    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    sciencedirect.com/science/article/pii/S2211124722016424
  57. Sep 2022
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    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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  59. Mar 2022
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    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
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    Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
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  62. Feb 2022
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    Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions
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  64. Dec 2021
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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  66. May 2021
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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  68. Feb 2021
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    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  71. Sep 2020
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    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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    sciencedirect.com/science/article/pii/S0006295220301775
  73. cancerres.aacrjournals.org cancerres.aacrjournals.org
    CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer
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    Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
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    Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells
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    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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  78. Jan 2020
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    PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
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    Perioperative infusion of glucagon like peptide-1 prevents insulin resistance after surgical trauma in female pigs
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    academic.oup.com/endo/article/160/12/2892/5581188
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    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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  83. Nov 2018
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    NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance
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    Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
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  86. Nov 2017
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    Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice
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