52 Matching Annotations
  1. Last 7 days
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    Celecoxib potentiates ribociclib-induced apoptosis and anti-tumor activity by co-targeting COX-2/NF-κB and PI3K/AKT/mTOR pathways in hormone receptor-positive/HER2-negative breast cancer
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    link.springer.com/article/10.1007/s10495-026-02340-z
  3. Jan 2026
  4. link.springer.com link.springer.com
    Repression of Polycomb Group Factor 1 Inhibits EMT Progression in Colon Cancers Cells via Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathway
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    link.springer.com/article/10.1007/s10620-025-09641-4
  5. Oct 2025
  6. www.sciencedirect.com www.sciencedirect.com
    Absence of BCAP in myeloid cells abrogates M2 macrophage differentiation and promotes anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2589004225019844
  7. www.sciencedirect.com www.sciencedirect.com
    Adipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing β-adrenergic signaling and lipolysis
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    sciencedirect.com/science/article/pii/S2211124725012161
  8. Sep 2025
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    4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia
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    link.springer.com/article/10.1007/s11011-025-01695-7
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Insulin potentiates mechanical responses in small dorsal root ganglion neurons by increasing the sensitization of TRPV4 channels
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    pmc.ncbi.nlm.nih.gov/articles/PMC12379057/
  11. Aug 2025
  12. www.sciencedirect.com www.sciencedirect.com
    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
  13. Jul 2025
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    Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis
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    link.springer.com/article/10.1186/s12906-025-04967-y
  15. Jun 2025
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    PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling
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    sciencedirect.com/science/article/pii/S0269749124003889
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141803/
  18. journals.sagepub.com journals.sagepub.com
    In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells
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    journals.sagepub.com/doi/full/10.1177/15347354251344592
  19. May 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12184535/
  21. Apr 2025
  22. www.jneurosci.org www.jneurosci.org
    Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease
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    jneurosci.org/content/45/10/e0967242025
  23. Dec 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity
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    sciencedirect.com/science/article/pii/S107476132400520X
  25. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  26. Sep 2024
  27. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286715
  28. Aug 2024
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    Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
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    sciencedirect.com/science/article/pii/S1535610824002708
  30. Jul 2024
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  32. Feb 2024
  33. link.springer.com link.springer.com
    Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma
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    link.springer.com/article/10.1007/s12010-024-04887-6
  34. Dec 2023
  35. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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    sciencedirect.com/science/article/pii/S2589004223026731
  36. Oct 2023
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Bilirubin impacts microglial autophagy via the Akt–mTOR signaling pathway
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.15984
  38. Aug 2023
  39. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    sciencedirect.com/science/article/pii/S1097276523005580
  40. Jul 2023
  41. www.sciencedirect.com www.sciencedirect.com
    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    sciencedirect.com/science/article/pii/S2589004223014189
  42. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10328411/
  44. Jun 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA
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    sciencedirect.com/science/article/pii/S0197018623000785
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Design of Diversified Chimeric Antigen Receptors Through Rational Module Recombination
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    sciencedirect.com/science/article/pii/S2589004223006065
  48. Feb 2023
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
  50. Jan 2023
  51. journals.lww.com journals.lww.com
    PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/PTEN_inhibitor_bisperoxovanadium_protects_against.36.aspx
  52. Dec 2022
  53. www.sciencedirect.com www.sciencedirect.com
    The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
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    sciencedirect.com/science/article/pii/S2211124722016424
  54. Sep 2022
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
  56. Mar 2022
  57. www.sciencedirect.com www.sciencedirect.com
    Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake
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    sciencedirect.com/science/article/pii/S2211124722002455
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC8850919/
  59. Feb 2022
  60. www.sciencedirect.com www.sciencedirect.com
    Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions
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    sciencedirect.com/science/article/pii/S0303720722000454
  61. Dec 2021
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8669767/
  63. May 2021
  64. www.sciencedirect.com www.sciencedirect.com
    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    sciencedirect.com/science/article/pii/S0021925821005287
  65. Feb 2021
  66. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15047
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle
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    onlinelibrary.wiley.com/doi/10.1002/jcb.29312
  68. Sep 2020
  69. www.sciencedirect.com www.sciencedirect.com
    Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
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    sciencedirect.com/science/article/pii/S0006295220301775
  70. cancerres.aacrjournals.org cancerres.aacrjournals.org
    CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer
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    cancerres.aacrjournals.org/content/80/2/334
  71. www.sciencedirect.com www.sciencedirect.com
    Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
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    sciencedirect.com/science/article/pii/S0092867420308837
  72. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15042
  73. www.mdpi.com www.mdpi.com
    Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells
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    mdpi.com/2077-0383/9/2/353
  74. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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    stke.sciencemag.org/content/13/621/eaax2364
  75. Jan 2020
  76. www.sciencedirect.com www.sciencedirect.com
    PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
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    sciencedirect.com/science/article/pii/S1074761319304613
  77. academic.oup.com academic.oup.com
    Perioperative infusion of glucagon like peptide-1 prevents insulin resistance after surgical trauma in female pigs
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    academic.oup.com/endo/article/160/12/2892/5581188
  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/jcb.29123
  79. link.springer.com link.springer.com
    Untitled document
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    link.springer.com/article/10.1007/s12640-018-9991-2
  80. Nov 2018
  81. content.iospress.com content.iospress.com
    NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad180284
  82. www.sciencedirect.com www.sciencedirect.com
    Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
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    sciencedirect.com/science/article/pii/S2211124718309641
  83. Nov 2017
  84. academic.oup.com academic.oup.com
    Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice
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    academic.oup.com/endo/article/158/10/3661/4049499/Aldose-Reductase-Mediates-NLRP3-Inflammasome