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Sep 2025
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4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia

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Insulin potentiates mechanical responses in small dorsal root ganglion neurons by increasing the sensitization of TRPV4 channels

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Aug 2025
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Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression

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Jul 2025
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Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis

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Jun 2025
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PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling

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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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In Vitro Anticancer Activity of Phytol on Human Non-Small Cell Lung Cancer A549 Cells

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May 2025
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Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation

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Apr 2025
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Cell adhesion molecule protocadherin-γC5 ameliorates Aβ plaque pathogenesis by modulating astrocyte function in Alzheimer’s disease

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Dec 2024
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Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity

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B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies

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Sep 2024
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Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus

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1. scibot 27 Sep 2024
  
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Aug 2024
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Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers

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Jul 2024
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Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer

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1. scibot 06 Jul 2024
  
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  DOI: 10.3892/or.2024.8760
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
Feb 2024
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Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Radix Paeoniae Rubra Against Glioma

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1. scibot 22 Feb 2024
  
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  DOI: 10.1007/s12010-024-04887-6
  
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Dec 2023
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KDM5B predicts temozolomide-resistant subclones in glioblastoma

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  DOI: 10.1016/j.isci.2023.108596
  
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Oct 2023
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Bilirubin impacts microglial autophagy via the Akt–mTOR signaling pathway

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1. scibot 27 Oct 2023
  
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  DOI: 10.1111/jnc.15984
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.15984
Aug 2023
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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1. scibot 11 Aug 2023
  
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  DOI: 10.1016/j.molcel.2023.07.015
  
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Jul 2023
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GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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  DOI: 10.1101/2023.05.18.541123
  
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Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling

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  DOI: 10.1126/sciadv.adg9593
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10328411/
Jun 2023
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Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA

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Apr 2023
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Design of Diversified Chimeric Antigen Receptors Through Rational Module Recombination

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Feb 2023
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Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

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ncbi.nlm.nih.gov/pmc/articles/PMC9912829/
Jan 2023
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PTEN inhibitor bisperoxovanadium protects against... : Neural Regeneration Research

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  DOI: 10.4103/1673-5374.358606
  
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journals.lww.com/nrronline/Fulltext/2023/07000/PTEN_inhibitor_bisperoxovanadium_protects_against.36.aspx
Dec 2022
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The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC

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Sep 2022
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Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

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  DOI: 10.3389/fimmu.2022.931087
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9513153/
Mar 2022
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Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

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Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model

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  DOI: 10.3389/fnins.2021.804722
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8850919/
Feb 2022
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Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions

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  DOI: 10.1016/j.mce.2022.111598
  
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sciencedirect.com/science/article/pii/S0303720722000454
Dec 2021
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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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  DOI: 10.3389/fphys.2021.779547
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8669767/
May 2021
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The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1

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1. scibot 18 May 2021
  
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sciencedirect.com/science/article/pii/S0021925821005287
Feb 2021
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BPS Publications

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1. scibot 25 Feb 2021
  
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  DOI: 10.1111/bph.15047
  
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MicroRNA‐34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle

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1. scibot 24 Feb 2021
  
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  DOI: 10.1002/jcb.29312
  
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onlinelibrary.wiley.com/doi/10.1002/jcb.29312
Sep 2020
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Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway

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CoA Synthase (COASY) mediates radiation resistance via PI3K signaling in rectal cancer

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  DOI: 10.1158/0008-5472.CAN-19-1161
  
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Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

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  DOI: 10.1016/j.cell.2020.07.018
  
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BPS Publications

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  DOI: 10.1111/bph.15042
  
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Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells

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  anti-PI3K
  
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stke.sciencemag.org stke.sciencemag.org

Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

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Jan 2020
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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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  DOI: 10.1016/j.immuni.2019.11.003
  
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Perioperative infusion of glucagon like peptide-1 prevents insulin resistance after surgical trauma in female pigs

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LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway

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  DOI: 10.1002/jcb.29123
  
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Untitled document

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  DOI: 10.1007/s12640-018-9991-2
  
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Nov 2018
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NO-Dependent Akt Inactivation by S-Nitrosylation as a Possible Mechanism of STZ-Induced Neuronal Insulin Resistance

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Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells

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Nov 2017
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Aldose Reductase Mediates NLRP3 Inflammasome–Initiated Innate Immune Response in Hyperglycemia-Induced Thp1 Monocytes and Male Mice

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