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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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1. scibot 06 Sep 2025
  
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  DOI: 10.1016/j.chembiol.2025.08.004
  
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sciencedirect.com/science/article/pii/S2451945625002557
Aug 2025
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Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

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1. scibot 07 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.011
  
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sciencedirect.com/science/article/pii/S153458072500468X
Jul 2025
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Ca2+-driven cytoplasmic backflow ensures spindle anchoring in fertilized mouse eggs

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.cub.2025.06.073
  
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cell.com/current-biology/fulltext/S0960-9822(25)00859-0
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1-s2.0-S2589004225013963-main-html.html

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1. scibot 19 Jul 2025
  
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  DOI: 10.1016/j.isci.2025.113135
  
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52.53.155.43/316a94b10220989a497f7cdb87f8d62a2ae1d34b/1-s2.0-S2589004225013963-main-html.html
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Growth Differentiation Factor 15 Induces Gastric Fundus Contraction Involving Cholinergic Excitation: Morphofunctional Evidence in Rodent Models

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1. scibot 11 Jun 2025
  
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  DOI: 10.1111/jcmm.70629
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12135347/
May 2025
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1-s2.0-S2589004225009344-main-html.html

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1. scibot 18 May 2025
  
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52.53.155.43/e92b07ea6d3b21022cca859701890e2812640a41/1-s2.0-S2589004225009344-main-html.html
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Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115647
  
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sciencedirect.com/science/article/pii/S2211124725004188
Apr 2025
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The activation of INF2 by Piezo1/Ca2+ is required for mesenchymal-to-amoeboid transition in confined environments

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1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.cub.2025.02.066
  
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sciencedirect.com/science/article/pii/S0960982225002805
Feb 2025
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Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions restricts epithelial permeability in Drosophila

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.cub.2025.01.043
  
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sciencedirect.com/science/article/pii/S0960982225000739
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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.cell.2025.01.021
  
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sciencedirect.com/science/article/pii/S0092867425000509
Sep 2024
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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cell.2024.08.013
  
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sciencedirect.com/science/article/pii/S0092867424009048
Aug 2024
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Cell-substrate distance fluctuations of confluent cells enable fast and coherent collective migration

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114553
  
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cell.com/cell-reports/abstract/S2211-1247(24)00882-9
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The FXR1 network acts as a signaling scaffold for actomyosin remodeling

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1. scibot 19 Aug 2024
  
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  DOI: 10.1016/j.cell.2024.07.015
  
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sciencedirect.com/science/article/pii/S009286742400775X
Jul 2024
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ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells

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1. scibot 19 Jul 2024
  
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  AB_330248
  
  DOI: 10.1016/j.isci.2024.110273
  
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sciencedirect.com/science/article/pii/S2589004224014986
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Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.cub.2020.04.041
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7342018/
analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com

Label-free three-dimensional imaging and quantitative analysis of living fibroblasts and myofibroblasts by holotomographic microscopy

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1. scibot 16 Jul 2024
  
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  DOI: 10.1002/jemt.24648
  
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analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jemt.24648
Jun 2024
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FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

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1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114297
  
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sciencedirect.com/science/article/pii/S2211124724006259
May 2024
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YAP/TAZ Drive Agrin–Matrix Metalloproteinase-12 Mediated Diabetic Skin Wound Healing

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1. scibot 30 May 2024
  
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  DOI: 10.1016/j.jid.2024.05.005
  
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sciencedirect.com/science/article/pii/S0022202X24003919
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Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101576
  
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sciencedirect.com/science/article/pii/S2666379124002684
Apr 2024
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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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1. scibot 25 Apr 2024
  
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  DOI: 10.1016/j.celrep.2021.108883
  
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sciencedirect.com/science/article/pii/S2211124721001972
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Environmentally dependent and independent control of 3D cell shape

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114016
  
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sciencedirect.com/science/article/pii/S2211124724003449
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ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

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1. scibot 12 Apr 2024
  
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  DOI: 10.7554/eLife.89261
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11006420/
Feb 2024
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Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration

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1. scibot 01 Feb 2024
  
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  DOI: 10.3389/fcell.2023.1257751
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10811798/
Nov 2023
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PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113414
  
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sciencedirect.com/science/article/pii/S2211124723014262
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β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108469
  
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sciencedirect.com/science/article/pii/S2589004223025464
Oct 2023
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MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.devcel.2023.09.010
  
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sciencedirect.com/science/article/pii/S1534580723005129
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Adiponectin Modulates Smooth Muscle Cell Morpho-Functional Properties in Murine Gastric Fundus via Sphingosine Kinase 2 Activation

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1. scibot 06 Oct 2023
  
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  DOI: 10.3390/life13091812
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10532860/
Sep 2023
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Chromosomal instability-induced cell invasion through caspase-driven DNA damage

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.cub.2023.09.004
  
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sciencedirect.com/science/article/abs/pii/S0960982223012174
dx.doi.org dx.doi.org

Protective effects of low-intensity pulsed ultrasound (LIPUS) against cerebral ischemic stroke in mice by promoting brain vascular remodeling via the inhibition of ROCK1/p-MLC2 signaling pathway

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1. scibot 30 Sep 2023
  
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  DOI: 10.1093/cercor/bhad330
  
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dx.doi.org/10.1093/cercor/bhad330
Aug 2023
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ZXDC Enhances Cervical Cancer Metastasis Through IGF2BP3-Mediated Activation of RhoA/ROCK Signaling

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1. scibot 26 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107447
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10433122/
Jul 2023
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Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration

1
1. scibot 18 Jul 2023
  
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  DOI: 10.1101/2023.06.23.546291
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10327004/
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Competition between myosin II and βH-spectrin regulates cytoskeletal tension

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1. scibot 12 Jul 2023
  
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  DOI: 10.7554/eLife.84918
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10328500/
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Length limitation of astral microtubules orients cell divisions in murine intestinal crypts

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1. scibot 07 Jul 2023
  
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  DOI: 10.1016/j.devcel.2023.06.004
  
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sciencedirect.com/science/article/abs/pii/S1534580723003027
Apr 2023
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Blastopore gating mechanism to regulate extracellular fluid excretion

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106585
  
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sciencedirect.com/science/article/pii/S2589004223006624
Mar 2023
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The role of rhoA/rho-kinase and PKC in the inhibitory effect of L-cysteine/H2S pathway on the carbachol-mediated contraction of mouse bladder smooth muscle

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1. scibot 14 Mar 2023
  
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  DOI: 10.1007/s00210-023-02440-6
  
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link.springer.com/article/10.1007/s00210-023-02440-6
Feb 2023
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Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers

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1. scibot 25 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.106090
  
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Nov 2022
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mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

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Ptp61F integrates Hippo, TOR, and actomyosin pathways to control three-dimensional organ size

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CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition

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Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

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Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions

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Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster

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Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling

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Fat body-derived Spz5 remotely facilitates tumor-suppressive cell competition through Toll-6-α-Spectrin axis-mediated Hippo activation

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Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme

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Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration

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Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians

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FEBS Press

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Force-generating apoptotic cells orchestrate avian neural tube bending

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A novel mechanism of bulk cytoplasmic transport by cortical dynein in Drosophila ovary

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Cell surface fluctuations regulate early embryonic lineage sorting

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RNA localization in confined cells depends on cellular mechanical activity and contributes to confined migration

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ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12

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Metastasis enhancer PGRMC1 boosts store-operated Ca2+ entry by uncoiling Ca2+ sensor STIM1 for focal adhesion turnover and actomyosin formation

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Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing

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Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

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The endocycle restores tissue tension in the Drosophila abdomen post wound repair

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Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

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Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics

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The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development

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Untitled document

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Untitled document

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Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction

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The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

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RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6

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YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

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Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering

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Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

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Generation of anisotropic strain dysregulates wild-type cell division at the interface between host and oncogenic tissue

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Adhesion-mediated mechanosignaling forces mitohormesis

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14–3-3γ prevents centrosome duplication by inhibiting NPM1 function

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  phospho-MLC2 (S19)
  
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Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor

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Apical Relaxation during Mitotic Rounding Promotes Tension-Oriented Cell Division

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The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis

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Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity

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Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling

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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

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Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer

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Transient opening of tricellular vertices controls paracellular transport through the follicle epithelium during Drosophila oogenesis

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An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads

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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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Integrin β1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition

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Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone

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Trophectoderm mechanics direct epiblast shape upon embryo implantation

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A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction

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Smoothelin-like 2 Inhibits Coronin-1B to Stabilize the Apical Actin Cortex during Epithelial Morphogenesis

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Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity

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  Rabbit polyclonal anti‐phosphomyosin light chain 2
  
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Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation

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Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration

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Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure

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Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

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Tissue Mechanics Regulate Mitotic Nuclear Dynamics during Epithelial Development

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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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Cell and tissue morphology determine actin-dependent nuclear migration mechanisms in neuroepithelia

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The ArfGAP Drongo Promotes Actomyosin Contractility during Collective Cell Migration by Releasing Myosin Phosphatase from the Trailing Edge

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Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4

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Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness

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Cell-Size Pleomorphism Drives Aberrant Clone Dispersal in Proliferating Epithelia

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The Tricellular Junction Protein Sidekick Regulates Vertex Dynamics to Promote Bicellular Junction Extension

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cell.2018.12.038
  
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1. scibot 12 Jan 2020
  
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  DOI: 10.1016/j.devcel.2019.02.023
  
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Nov 2018
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Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

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1. scibot 05 Nov 2018
  
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Combinatorial Contact Cues Specify Cell Division Orientation by Directing Cortical Myosin Flows

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The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells

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Untitled document

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1. scibot 05 Nov 2018
  
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Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

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Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

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Nov 2017
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Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue

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Patterned cortical tension mediated by N-cadherin controls cell geometric order in the Drosophila eye

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1. scibot 08 Nov 2017
  
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Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

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1. scibot 08 Nov 2017
  
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Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction

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1. scibot 08 Nov 2017
  
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